Terminology Service < Semantic Lookup Platform

All terms in BAO

Label	Id	Description
EC50	BAO_0000188	[The effective concentration of an agonist, which produces 50% of the maximum possible response for that agonist.]
CC50	BAO_0000187	[The effective concentration of a cytotoxic compound, which produces 50% of the maximum possible cell death for that compound. Although the cytotoxic compound induces cell death, we define CC50 as subclass of IC50, because critical cellular processes are inhibited and CC50 is often used as a more specific description of IC50 for cell toxicity assays. Compound cytotoxicity is an important parameter to measure when developing potential human therapeutics. Cytotoxicity can be determined for example as a measure of radioisotope (3H thymidine or 51Cr) release, lactate dehydrogenase release from damaged cells, tetrazolium salt and alamar blue reduction, fluorescent dyes that selectively stain live or dead cells, or decrease in ATP content. ATP levels are detected using a luminescence based assay kit such as CellTiter-Glo (Promega). ATP values higher than controls (untreated cells) indicate proliferation and cultures with ATP concentrations lower than controls indicate cytotoxicity. ]
inhalation anaesthetic	CHEBI_38870
general anaesthetic	CHEBI_38869
image-based readout	BAO_0000184	[High content screening (HCS) is an automated screening method using live cells to understand various aspects of their biology. HCS employs imaging (bright-field or fluorescence) and analyses in a high throughput format. HCS can be applied to monitor complex cellular aspects, namely, signaling, morphology, phenotype, proliferation, motility, intracellular trafficking, toxicology, RNAi knockdown, and receptor activation.]
assay readout content	BAO_0002169
intravenous anaesthetic	CHEBI_38877
nodulation factor	CHEBI_25573
biological role	CHEBI_24432
biological role	BAO_0110002
scabies	DOID_8295	[A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite Sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.]
mite infestation	DOID_7894	[A parasitic ectoparasitic infectious disease that involves infestation of mites belonging to the family Sarcoptidae, Trombiculidae and Demodicidae.]
pIC50	BAO_0000199	[pIC50 is -log IC50, where IC50 is the effective concentration of an inhibitor, which produces 50% of the maximum possible response for that inhibitor.]
IC50 relative	BAO_0000198	[The concentration of a test substance that produces an inhibitory effect corresponding to 50% of the activity of that particular substance (i.e. 50% of the difference between top and bottom of fitted curve). It can also be described as the concentration corresponding to the inflection point of the curve.]
EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor	CHEBI_73216
EC 3.* (hydrolase) inhibitor	CHEBI_76759
IC50 absolute	BAO_0000197	[Absolute IC50 (calculated from the curve-fit function) is the concentration corresponding to exactly 50 percent inhibition. It is obtained from the curve fit function (back-calculated IC50) and can also be extrapolated. Commonly the relative IC50 is reported; however in cell proliferation assays absolute IC50 is often used. The absolute IC50 can be more reproducible.]
EC 3.6.3.14 (H(+)-transporting two-sector ATPase) inhibitor	CHEBI_73214
EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor	CHEBI_76895
TGI	BAO_0000194	[TGI is total growth inhibition, which is the effective concentration of a growth inhibitor, which produces 0% relative growth for that inhibitor. Thus TGI signifies a cytostatic effect. tgi is calculated from [(Ti-Tz)/(C-Tz)] x 100 =0, where Ti = Tz and Tz is absorbance at time zero, Ti is absorbance in the presence of test drug, and C is absorbance in the control (untreated cells). As a measure of viable cells, different researchers measure different parameters, namely, protein content (by sulforhodamine B staining followed by absorbance measurement), mitochondrial dehydrogenase activity (by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrasodium bromide, known as MTT staining followed by absorbance measurement), and ATP content (by using CellTiter-Glo reagent (Promega) followed by luminescence measurement).]