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artemether

Go to external page http://purl.obolibrary.org/obo/CHEBI_195280

An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.

Term info

Label

artemether

Synonyms
  • (3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepine
database cross reference
Subsets

3_STAR

INN
artemetero [ ChemIDplus ]

IUPAC NAME
(3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepine [ IUPAC ]

INN
artemetherum [ ChemIDplus ]

INN
artemether [ KEGG_DRUG ]

charge

0

formula

C16H26O5

has obo namespace

chebi_ontology

has related synonym

(1R,4S,5R,8S,9R,10S,12R,13R)-10-methoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecane, methyl-dihydroartemisinine, beta-dihydroartemisinin methyl ether, artemetero, 10-methoxy-1,5,9-trimethyl-(1R,4S,5R,8S,9R,10S,12R,13R)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecane, beta-artemether, artemisininelactol methyl ether, artemether, artemetherum, dihydroartemisinin methyl ether

id

CHEBI:195280

inchi

InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1

inchikey

SXYIRMFQILZOAM-HVNFFKDJSA-N

mass

298.37460

monoisotopicmass

298.17802

smiles

[H][C@@]12CC[C@@]3(C)OO[C@@]11[C@@]([H])(CC[C@H]2C)[C@@H](C)[C@@H](OC)O[C@]1([H])O3