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proglumetacin dimaleate

Go to external page http://purl.obolibrary.org/obo/CHEBI_32057

A maleate salt obtained by combining proglumetacin with two molar equivalents of maleic acid. Used to control pain and inflammation associated with musculoskeletal and joint disorders. Following oral adminitration, it is metabolied to indometacin and proglumide, a drug with antisecretory effects that helps prevent injury to the stomach lining.

Term info

Label

proglumetacin dimaleate

Synonyms
  • 3-[4-(2-{2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetoxy}ethyl)piperazin-1-yl]propyl N(2)-benzoyl-N,N-dipropyl-alpha-glutaminate di[(2Z)-but-2-enedioate]
database cross reference
Subsets

3_STAR

BRAND NAME
Miridacin [ KEGG_DRUG ]

IUPAC NAME
3-[4-(2-{2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetoxy}ethyl)piperazin-1-yl]propyl N(2)-benzoyl-N,N-dipropyl-alpha-glutaminate di[(2Z)-but-2-enedioate] [ IUPAC ]

charge

0

formula

C54H66ClN5O16, C46H58ClN5O8.2C4H4O4

has obo namespace

chebi_ontology

has related synonym

Proglumetacin maleate, Miridacin

id

CHEBI:32057

inchi

InChI=1S/C46H58ClN5O8.2C4H4O4/c1-5-21-51(22-6-2)46(57)40(48-44(55)34-11-8-7-9-12-34)18-20-42(53)59-29-10-23-49-24-26-50(27-25-49)28-30-60-43(54)32-38-33(3)52(41-19-17-37(58-4)31-39(38)41)45(56)35-13-15-36(47)16-14-35;2*5-3(6)1-2-4(7)8/h7-9,11-17,19,31,40H,5-6,10,18,20-30,32H2,1-4H3,(H,48,55);2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-

inchikey

MKFWBVKQDGNXDW-SPIKMXEPSA-N

mass

1076.57900

monoisotopicmass

1075.41931

smiles

OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.CCCN(CCC)C(=O)C(CCC(=O)OCCCN1CCN(CCOC(=O)Cc2c(C)n(C(=O)c3ccc(Cl)cc3)c3ccc(OC)cc23)CC1)NC(=O)c1ccccc1