Terminology Service for NFDI4Health
formestane
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http://purl.obolibrary.org/obo/CHEBI_75172
A 17-oxo steroid that is androst-4-ene-3,17-dione in which the hydrogen at position 4 is replaced by a hydroxy group. Formestane was the first selective, type I steroidal aromatase inhibitor, suppressing oestrogen production from anabolic steroids or prohormones. It was formerly used in the treatment of oestrogen-receptor positive breast cancer in post-meopausal women. As it has poor oral bioavailability, it had to be administered by (fortnightly) intramuscular injection. It fell out of use with the subsequent development of cheaper, orally active aromatase inhibitors. Formestane is listed by the World Anti-Doping Agency as a substance prohibited from use by athletes.
Term info
Label
formestane
Synonyms
- 4-hydroxyandrost-4-ene-3,17-dione
Subsets
3_STAR
charge
0
formula
C19H26O3
has obo namespace
chebi_ontology
has related synonym
formestano, 4-hydroxy-Delta(4)-androstenedione, formestanum, 4-hydroxyandrostenedione, CGP 32349, formestane, CGP-32349, 4-hydroxy-4-androstene-3,17-dione, Lentaron, 4-OH-A, 4-OHAD
id
CHEBI:75172
inchi
InChI=1S/C19H26O3/c1-18-10-8-15(20)17(22)14(18)4-3-11-12-5-6-16(21)19(12,2)9-7-13(11)18/h11-13,22H,3-10H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1
inchikey
OSVMTWJCGUFAOD-KZQROQTASA-N
mass
302.40790
monoisotopicmass
302.18819
smiles
[H][C@@]12CCC3=C(O)C(=O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)C(=O)CC[C@@]21[H]