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proglumetacin

Go to external page http://purl.obolibrary.org/obo/CHEBI_76263

A carboxylic ester obtained by formal condensation of the carboxy group of indometacin with the hydroxy group of 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl N(2)-benzoyl-N,N-dipropyl-alpha-glutaminate. Used (as its dimaleate salt) to control pain and inflammation associated with musculoskeletal and joint disorders. Following oral administration, it is metabolised to indometacin and proglumide, a drug with antisecretory effects that helps prevent injury to the stomach lining.

Term info

Label

proglumetacin

Synonyms
  • 3-[4-(2-{2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetoxy}ethyl)piperazin-1-yl]propyl N(2)-benzoyl-N,N-dipropyl-alpha-glutaminate
database cross reference
Subsets

3_STAR

INN
proglumetacine [ WHO_MedNet ]

INN
proglumetacinum [ ChemIDplus ]

IUPAC NAME
3-[4-(2-{2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetoxy}ethyl)piperazin-1-yl]propyl N(2)-benzoyl-N,N-dipropyl-alpha-glutaminate [ IUPAC ]

INN
proglumetacin [ KEGG_DRUG ]

INN
proglumetacina [ ChemIDplus ]

charge

0

formula

C46H58ClN5O8

has obo namespace

chebi_ontology

has related synonym

proglumetacinum, proglumetacina, proglumetacin, proglumetacine

id

CHEBI:76263

inchi

InChI=1S/C46H58ClN5O8/c1-5-21-51(22-6-2)46(57)40(48-44(55)34-11-8-7-9-12-34)18-20-42(53)59-29-10-23-49-24-26-50(27-25-49)28-30-60-43(54)32-38-33(3)52(41-19-17-37(58-4)31-39(38)41)45(56)35-13-15-36(47)16-14-35/h7-9,11-17,19,31,40H,5-6,10,18,20-30,32H2,1-4H3,(H,48,55)

inchikey

PTXGHCGBYMQQIG-UHFFFAOYSA-N

mass

844.43400

monoisotopicmass

843.39739

smiles

CCCN(CCC)C(=O)C(CCC(=O)OCCCN1CCN(CCOC(=O)Cc2c(C)n(C(=O)c3ccc(Cl)cc3)c3ccc(OC)cc23)CC1)NC(=O)c1ccccc1