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LGK974

Go to external page http://purl.obolibrary.org/obo/CHEBI_78030

A carboxamide, the structure of which is that of acetamide substituted on carbon by a 2',3-dimethyl-2,4'-bipyridin-5-yl group and on nitrogen by a 5-(pyrazin-2-yl)pyridin-2-yl group. It is a highly potent, selective and orally bioavailable Porcupine inhibitor (a Wnt signalling inhibitor).

Term info

Label

LGK974

Synonyms
  • 2-(2',3-dimethyl-2,4'-bipyridin-5-yl)-N-[5-(pyrazin-2-yl)pyridin-2-yl]acetamide
database cross reference
Subsets

3_STAR

IUPAC NAME
2-(2',3-dimethyl-2,4'-bipyridin-5-yl)-N-[5-(pyrazin-2-yl)pyridin-2-yl]acetamide [ IUPAC ]

charge

0

formula

C23H20N6O

has obo namespace

chebi_ontology

id

CHEBI:78030

inchi

InChI=1S/C23H20N6O/c1-15-9-17(12-28-23(15)18-5-6-25-16(2)10-18)11-22(30)29-21-4-3-19(13-27-21)20-14-24-7-8-26-20/h3-10,12-14H,11H2,1-2H3,(H,27,29,30)

inchikey

XXYGTCZJJLTAGH-UHFFFAOYSA-N

mass

396.44450

monoisotopicmass

396.16986

smiles

Cc1cc(ccn1)-c1ncc(CC(=O)Nc2ccc(cn2)-c2cnccn2)cc1C