Terminology Service for NFDI4Health
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proguanil

Go to external page http://purl.obolibrary.org/obo/CHEBI_8455

A biguanide compound which has isopropyl and p-chlorophenyl substituents on the terminal N atoms. A prophylactic antimalarial drug, it works by inhibiting the enzyme dihydrofolate reductase, which is involved in the reproduction of the malaria parasites Plasmodium falciparum and P. vivax within the red blood cells.

Term info

Label

proguanil

Synonyms
  • N-(4-chlorophenyl)-N'-(propan-2-yl)imidodicarbonimidic diamide
database cross reference
Subsets

3_STAR

IUPAC NAME
N-(4-chlorophenyl)-N'-(propan-2-yl)imidodicarbonimidic diamide [ IUPAC ]

INN
proguanil [ ChemIDplus ]

INN
proguanilum [ ChemIDplus ]

charge

0

formula

C11H16ClN5

has obo namespace

chebi_ontology

has related synonym

proguanil, Chloroguanide, proguanilum, N-(4-Chlorophenyl)-N'-(isopropyl)-imidodicarbonimidic diamide, 1-(p-chlorophenyl)-5-isopropylbiguanide, Chlorguanide

id

CHEBI:8455

inchi

InChI=1S/C11H16ClN5/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9/h3-7H,1-2H3,(H5,13,14,15,16,17)

inchikey

SSOLNOMRVKKSON-UHFFFAOYSA-N

mass

253.73100

monoisotopicmass

253.10942

smiles

CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1