rolapitant hydrochloride (anhydrous)
A hydrochloride obtained by combining irinotecan with one molar equivalent of hydrochloric acid. Used (in the form of the hydrate) for the prevention of delayed nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy.
Term info
rolapitant hydrochloride (anhydrous)
- (5S,8S)-8-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-2-oxo-8-phenyl-1,7-diazaspiro[4.5]decan-7-ium chloride
- (5S,8S)-8-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-8-phenyl-1,7-diazaspiro[4.5]decan-2-one hydrochloride
3_STAR
0
C25H27ClF6N2O2
chebi_ontology
SCH619734, rolapitant hydrochloride, rolapitant.HCl, SCH 619734, Rolapitant hydrochloride anhydrous, rolapitant monohydrochloride
CHEBI:90912
InChI=1S/C25H26F6N2O2.ClH/c1-16(17-11-19(24(26,27)28)13-20(12-17)25(29,30)31)35-15-23(18-5-3-2-4-6-18)10-9-22(14-32-23)8-7-21(34)33-22;/h2-6,11-13,16,32H,7-10,14-15H2,1H3,(H,33,34);1H/t16-,22-,23-;/m1./s1
VEWAWEMXVUFANV-PVBCUUEWSA-N
536.938
536.16652
C1=C(C=C(C=C1C(F)(F)F)C(F)(F)F)[C@H](OC[C@@]2(NC[C@]3(CC2)CCC(N3)=O)C4=CC=CC=C4)C.Cl
Term relations
- hydrochloride
- has role some antiemetic
- has part some rolapitant(1+)
- has role some neurokinin-1 receptor antagonist