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Kupffer cell

Go to external page http://purl.obolibrary.org/obo/CL_0000091

A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system. [ http://purl.obolibrary.org/obo/go/references/0000031 http://www.ncbi.nlm.nih.gov/pubmed/17105582 https://www.worldcat.org/search?q=bn%3A0517223651 http://www.ncbi.nlm.nih.gov/pubmed/15771589 ]

Term info

Label

Kupffer cell

Synonyms
  • hepatic macrophage
  • littoral cell of hepatic sinusoid
  • liver macrophage
  • macrophagocytus stellatus
  • stellate cell of von Kupffer
  • von Kupffer cell
database cross reference
comment

Markers: Mouse: F4/80+, CD11b-low, CD68+, sialoadhesin+, CD163/SRCR+; role or process: immune, antigen-presentation, clearance of senescent erythrocytes, iron metabolism. Kupffer cells are also reportedly C3aR-positive, CD14-low, CD54-positive, CD88-positive, and CD284-positive. They are also capable of producing IL-1, IL-6, TNF-alpha, nitric oxide, PGD2, PGE2, PGF2alpha, and TXA2.