Terminology Service for NFDI4Health
osteoclast
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http://purl.obolibrary.org/obo/CL_0000092
A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive. [ https://www.worldcat.org/search?q=bn%3A0781735149 http://www.ncbi.nlm.nih.gov/pubmed/15055519 http://www.ncbi.nlm.nih.gov/pubmed/10428500 http://purl.obolibrary.org/obo/go/references/0000031 http://www.ncbi.nlm.nih.gov/pubmed/17380158 ]
Term info
Label
osteoclast
comment
Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid.
has obo namespace
cell
has related synonym
chondroclast
Term relations
Equivalent to:
- myeloid leukocyte and part of some bone element and has_part some cathepsin K and has_part some tartrate-resistant acid phosphatase type 5 and has_part some transcription factor PU.1 and has_part some proto-oncogene c-Fos and has_part some nuclear factor NF-kappa-B p100 subunit and has plasma membrane part some tumor necrosis factor receptor superfamily member 11A and has plasma membrane part some macrophage colony-stimulating factor 1 receptor and capable of some bone resorption
Subclass of:
- myeloid leukocyte
- material anatomical entity
- bone cell
- capable of some bone resorption
- has_part some cathepsin K
- has_part some nuclear factor NF-kappa-B p100 subunit
- develops from some monocyte
- has_part some proto-oncogene c-Fos
- has_part some tartrate-resistant acid phosphatase type 5
- has plasma membrane part some tumor necrosis factor receptor superfamily member 11A
- has plasma membrane part some macrophage colony-stimulating factor 1 receptor
- has_part some transcription factor PU.1