Terminology Service for NFDI4Health
mature neutrophil
Go to external page
http://purl.obolibrary.org/obo/CL_0000096
A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. They are produced in bone marrow at a rate of 5e10-10e10/day and have a half-life of 6-8 hours. Neutrophils are CD15-positive, CD16-positive, CD32-positive, CD43-positive, CD181-positive, and CD182-positive. [ http://www.cap.org http://www.ncbi.nlm.nih.gov/pubmed/12560239 http://www.ncbi.nlm.nih.gov/pubmed/7880385 http://www.ncbi.nlm.nih.gov/pubmed/11138776 http://www.ncbi.nlm.nih.gov/pubmed/15514007 ]
Term info
Label
mature neutrophil
Synonyms
- PMN
- mature neutrocyte
- mature neutrophil leucocyte
- mature neutrophil leukocyte
- mature neutrophilic leucocyte
- mature neutrophilic leukocyte
- polymorphonuclear neutrophil
- polynuclear neutrophilic leucocyte
- polynuclear neutrophilic leukocyte
comment
Neutrophils are also capable of secreting GRO-alpha, IL-1beta, IL-1ra, IL-3, IL-12, IP-10, MIG, MIP-1alpha, MIP-1beta, TGF-beta, TNF-alpha, VEGF, and anti-microbial peptides. They can positively influence the chemotaxis of basophils, T-cells, monocytes, macrophages, dendritic cells, and other neutrophils. Neutrophils are also CD35-positive, CD64-positive, CD89-positive, CD184-positive, and fMLP receptor-positive Ly-6G-positive (mouse), TLR2-low, TLR4-low, and lineage-negative (CD2, CD3, CD5, CD9, CD19, CD36, CD49d, CD56, CD61, CD235a (glycophorin-A)).
has broad synonym
polymorphonuclear leucocyte, poly, polymorphonuclear leukocyte
has obo namespace
cell
Term relations
Equivalent to:
- neutrophil and has_part some neutrophillic cytoplasm and has_part some lobed nucleus and has_part some tertiary granule and has plasma membrane part some C-X-C chemokine receptor type 1 and has plasma membrane part some C-X-C chemokine receptor type 2 and has plasma membrane part some alpha-(1,3)-fucosyltransferase FUT4 and has plasma membrane part some low affinity immunoglobulin gamma Fc region receptor III and has plasma membrane part some leukosialin and has plasma membrane part some transcription factor PU.1 and has plasma membrane part some proto-oncogene c-Fos and capable of some respiratory burst involved in inflammatory response and capable of some positive regulation of leukocyte chemotaxis and capable of some phagocytosis and capable of some interleukin-8 production and lacks_part some lactotransferrin and lacks_part some myeloperoxidase and lacks_part some myb proto-oncogene protein
Subclass of:
- phagocyte
- neutrophil
- nucleate cell
- has_part some tertiary granule
- has plasma membrane part some transcription factor PU.1
- capable of some positive regulation of leukocyte chemotaxis
- has plasma membrane part some C-X-C chemokine receptor type 1
- lacks_part some lactotransferrin
- has_part some neutrophillic cytoplasm
- has plasma membrane part some alpha-(1,3)-fucosyltransferase FUT4
- has_part some lobed nucleus
- lacks_part some myeloperoxidase
- has plasma membrane part some proto-oncogene c-Fos
- has plasma membrane part some C-X-C chemokine receptor type 2
- capable of some respiratory burst involved in inflammatory response
- lacks_part some myb proto-oncogene protein
- capable of some interleukin-8 production
- has plasma membrane part some low affinity immunoglobulin gamma Fc region receptor III