Terminology Service for NFDI4Health
mast cell
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http://purl.obolibrary.org/obo/CL_0000097
A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development. [ http://www.ncbi.nlm.nih.gov/pubmed/16455980 https://www.worldcat.org/search?q=bn%3A068340007X https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855166 http://www.ncbi.nlm.nih.gov/pubmed/19671378 http://www.ncbi.nlm.nih.gov/pubmed/9354811 http://www.ncbi.nlm.nih.gov/pubmed/15153310 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1312421 http://www.ncbi.nlm.nih.gov/pubmed/212366338 ]
Term info
Label
mast cell
Synonyms
- histaminocyte
- labrocyte
- mastocyte
comment
Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5.
has obo namespace
cell
has related synonym
tissue basophil
Term relations
Equivalent to:
- myeloid leukocyte and has_part some secretory granule and has plasma membrane part some C-C chemokine receptor type 3 and has plasma membrane part some cell surface glycoprotein CD200 receptor 3 and capable of some histamine production involved in inflammatory response and capable of some prostaglandin production involved in inflammatory response and capable of some positive regulation of peripheral tolerance induction and capable of some positive regulation of leukocyte chemotaxis and capable of some positive regulation of type 2 immune response and capable of some heparin biosynthetic process and has_high_plasma_membrane_amount some mast/stem cell growth factor receptor and has_high_plasma_membrane_amount some high affinity immunoglobulin epsilon receptor subunit alpha and lacks_plasma_membrane_part some interleukin-3 receptor class 2 alpha chain
Subclass of:
- histamine secreting cell
- myeloid leukocyte
- material anatomical entity
- has_part some secretory granule
- develops from some mast cell progenitor
- capable of some positive regulation of leukocyte chemotaxis
- capable of some positive regulation of type 2 immune response
- has_high_plasma_membrane_amount some high affinity immunoglobulin epsilon receptor subunit alpha
- has plasma membrane part some cell surface glycoprotein CD200 receptor 3
- lacks_plasma_membrane_part some interleukin-3 receptor class 2 alpha chain
- capable of some heparin biosynthetic process
- capable of some positive regulation of peripheral tolerance induction
- capable of some prostaglandin production involved in inflammatory response
- capable of some histamine production involved in inflammatory response
- has_high_plasma_membrane_amount some mast/stem cell growth factor receptor
- has plasma membrane part some C-C chemokine receptor type 3