Terminology Service for NFDI4Health
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microglial cell

Go to external page http://purl.obolibrary.org/obo/CL_0000129

A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive. [ http://www.ncbi.nlm.nih.gov/pubmed/11517395 http://www.ncbi.nlm.nih.gov/pubmed/12430718 http://www.ncbi.nlm.nih.gov/pubmed/16177057 http://en.wikipedia.org/wiki/Microglia https://www.worldcat.org/search?q=bn%3A0721601464 http://www.ncbi.nlm.nih.gov/pubmed/19461673 http://www.ncbi.nlm.nih.gov/pubmed/14612429 http://www.ncbi.nlm.nih.gov/pubmed/2089275 http://www.ncbi.nlm.nih.gov/pubmed/14561199 ]

Term info

Label

microglial cell

Synonyms
  • brain-resident macrophage
  • hortega cells
  • microglia
  • microgliocyte
database cross reference
comment

Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive.

has broad synonym

brain macrophage

has related synonym

MF.microglia.CNS