Terminology Service for NFDI4Health
mesenchymal stem cell
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http://purl.obolibrary.org/obo/CL_0000134
A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. This cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs. [ http://www.ncbi.nlm.nih.gov/pubmed/10102814j http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells http://www.ncbi.nlm.nih.gov/pubmed/19960544 http://flybase.org/reports/ma.html http://www.ncbi.nlm.nih.gov/pubmed/17986482 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613570 http://en.wikipedia.org/wiki/Mesenchymal_stem_cell http://www.ncbi.nlm.nih.gov/pubmed/16923606 ]
Term info
Label
mesenchymal stem cell
comment
Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.
has alternative id
CL:0002452
has narrow synonym
bone marrow stromal cells, BMSC, colony-forming unit-fibroblast, marrow stromal cells
has obo namespace
cell
has related synonym
mesenchymal stem cell, mesenchymal progenitor cells, mesenchymal stromal cells, mesenchymal precursor cell, stem cells, mesenchymal, CFU-F, mesenchymal stromal cell, MSC
Term relations
Equivalent to:
- connective tissue cell and has plasma membrane part some endoglin and has plasma membrane part some 5'-nucleotidase and has plasma membrane part some Thy-1 membrane glycoprotein and capable of some osteoblast differentiation and capable of some cell migration and capable of some neuron differentiation and capable of some epithelial cell differentiation and capable of some fat cell differentiation and capable of some cardiac muscle cell differentiation and capable of some chondroblast differentiation and lacks_plasma_membrane_part some MHC class II protein complex and lacks_plasma_membrane_part some CD34 molecule and lacks_plasma_membrane_part some receptor-type tyrosine-protein phosphatase C
Subclass of:
- motile cell
- material anatomical entity
- connective tissue cell
- multi fate stem cell
- capable of some chondroblast differentiation
- capable of some cell migration
- lacks_plasma_membrane_part some CD34 molecule
- capable of some fat cell differentiation
- capable of some osteoblast differentiation
- capable of some neuron differentiation
- has plasma membrane part some 5'-nucleotidase
- lacks_plasma_membrane_part some receptor-type tyrosine-protein phosphatase C
- has plasma membrane part some Thy-1 membrane glycoprotein
- capable of some cardiac muscle cell differentiation
- lacks_plasma_membrane_part some MHC class II protein complex
- capable of some epithelial cell differentiation
- has plasma membrane part some endoglin