Langerhans cell
Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus. [ http://purl.obolibrary.org/obo/go/references/0000031 https://www.worldcat.org/search?q=bn%3A0721601464 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2346585 http://www.ncbi.nlm.nih.gov/pubmed/17850486 https://www.worldcat.org/search?q=bn%3A0781735149 ]
Term info
Langerhans cell
- LC
- Langerhans' cell
Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID:19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis.
cell
Term relations
- conventional dendritic cell and has plasma membrane part some C-type lectin domain family 4 member K and capable of some regulation of type 2 immune response