Terminology Service for NFDI4Health

Langerhans cell

Go to external page http://purl.obolibrary.org/obo/CL_0000453


Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus. [ http://purl.obolibrary.org/obo/go/references/0000031 https://www.worldcat.org/search?q=bn%3A0721601464 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2346585 http://www.ncbi.nlm.nih.gov/pubmed/17850486 https://www.worldcat.org/search?q=bn%3A0781735149 ]

Term info

Label

Langerhans cell

Synonyms
  • LC
  • Langerhans' cell
database cross reference
comment

Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID:19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis.