Terminology Service for NFDI4Health
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mucosal type mast cell

Go to external page http://purl.obolibrary.org/obo/CL_0000485

Mast cell subtype that contains only the serine protease trypase in its granules. These cells are primarily found in mucosal tissue, such as intestinal mucosa and alveoli. They depend upon T-cells for development of phenotype. [ http://www.ncbi.nlm.nih.gov/pubmed/9354811 http://www.ncbi.nlm.nih.gov/pubmed/19923473 ]

Term info

Label

mucosal type mast cell

Synonyms
  • MC(T)
  • MCT
  • T mast cells
comment

They are CD88-negative. The cytoplasmic granules contain low levels of histamine and high levels of chondroitin sulfate (mouse) or major neutral proteases and tryptase (humans). Additionally, they can produce leukotrienes (LTC4), IL-5, IL-6, and low levels of IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype.