Terminology Service for NFDI4Health
T-helper 2 cell
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http://purl.obolibrary.org/obo/CL_0000546
A CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive, CXCR3-negative, CCR6-negative, and is capable of producing interleukin-4. [ http://www.ncbi.nlm.nih.gov/pubmed/22343568 http://www.ncbi.nlm.nih.gov/pubmed/19375293 http://purl.obolibrary.org/obo/go/references/0000031 http://www.ncbi.nlm.nih.gov/pubmed/20103781 ]
Term info
Label
T-helper 2 cell
Synonyms
- T helper cells type 2
- T(H)-2 cell
- Th2 T cell
- Th2 T lymphocyte
- Th2 T-cell
- Th2 T-lymphocyte
- Th2 cell
- helper T cell type 2
comment
This cell type is compatible with the HIPC Lyoplate markers for 'non-Th1/Th17 CD4+ T cell' (see CL:0001051), but includes the additional necessary and sufficient conditions to allow classification as a T-helper 2 T cell.
has obo namespace
cell
Term relations
Equivalent to:
- CD4-positive helper T cell and has_part some trans-acting T-cell-specific transcription factor GATA-3 and capable of some interleukin-4 production and lacks_plasma_membrane_part some C-C chemokine receptor type 6 and lacks_plasma_membrane_part some C-X-C chemokine receptor type 3