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granulocyte monocyte progenitor cell

http://purl.obolibrary.org/obo/CL_0000557

A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1. [ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC548021 http://en.wikipedia.org/wiki/CFU-GM https://www.worldcat.org/search?q=bn%3A0721601464 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213186 http://purl.obolibrary.org/obo/go/references/0000031 http://www.ncbi.nlm.nih.gov/pubmed/16551251 http://www.ncbi.nlm.nih.gov/pubmed/16647566 http://www.copewithcytokines.de ]

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Term info

Label

granulocyte monocyte progenitor cell

Synonyms

CFU-GM
GMP
colony forming unit granulocyte macrophage
granulocyte-macrophage progenitor
granulocyte/monocyte precursor
granulocyte/monocyte progenitor

comment

Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.

has broad synonym

CFU-C , Colony forming unit in culture

has obo namespace

cell

Term relations

Equivalent to:

hematopoietic oligopotent progenitor cell and part of some bone marrow and has_part some transcription factor PU.1 and has_part some CCAAT/enhancer-binding protein alpha and has plasma membrane part some interleukin-3 receptor class 2 alpha chain and capable of some macrophage differentiation and capable of some granulocyte differentiation and lacks_part some erythroid transcription factor and lacks_part some endothelial transcription factor GATA-2

Subclass of:

Related from:

develops_from