Terminology Service for NFDI4Health
neutrophilic promyelocyte
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http://purl.obolibrary.org/obo/CL_0000564
A promyelocyte committed to the neutrophil lineage. This cell type is GATA-1-positive, C/EBPa-positive, AML-1-positive, MPO-positive, has low expression of PU.1 transcription factor and lacks lactotransferrin expression. [ http://www.ncbi.nlm.nih.gov/pubmed/12560239 http://www.ncbi.nlm.nih.gov/pubmed/15514007 https://www.worldcat.org/search?q=bn%3A0721601464 ]
Term info
Label
neutrophilic promyelocyte
Synonyms
- neutrophilic premyelocyte
- neutrophilic progranulocyte
comment
These cells are CD11b-negative, CD15-positive, CD16-negative, CD49d-positive, CD68-positive, CD35-negative, and fMLP receptor-negative. They are found in the Band 3 fraction.
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cell
Term relations
Equivalent to:
- promyelocyte and has_part some transcription factor PU.1 and has_part some CCAAT/enhancer-binding protein alpha and has_part some erythroid transcription factor and has_part some myeloperoxidase and has_part some runt-related transcription factor 1 and capable of some neutrophil differentiation and lacks_part some lactotransferrin
Subclass of:
- promyelocyte
- neutrophil progenitor cell
- has_part some myeloperoxidase
- has_part some CCAAT/enhancer-binding protein alpha
- develops from some neutrophilic myeloblast
- lacks_part some lactotransferrin
- has_part some erythroid transcription factor
- has_part some runt-related transcription factor 1
- has_part some transcription factor PU.1
Related from: