neutrophilic metamyelocyte
A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and the band form neutrophil. The protein synthesis seen in earlier stages decreases or stops; the nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare; and the cytoplasm becomes amphophilic like that of a mature granulocyte. This cell type is integrin alpha-M-positive, CD13-negative, CD15-positive, CD16-positive, CD33-positive, CD24-positive, fMLP receptor-negative and has expression of C/EBP-a, C/EBP-e, PU.1 transcription factor, lactotransferrin, myeloperoxidase and neutrophil gelatinase associated lipocalin. [ http://www.cap.org http://www.ncbi.nlm.nih.gov/pubmed/12560239 https://www.worldcat.org/search?q=bn%3A0721601464 http://www.ncbi.nlm.nih.gov/pubmed/10618520 http://www.ncbi.nlm.nih.gov/pubmed/15514007 ]
Term info
neutrophilic metamyelocyte
- juvenile neutrophil
These cells are also CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction.
cell
Term relations
- immature neutrophil and has_part some acidophilic cytoplasm and has_part some reniform nucleus and has_part some heterochromatin and has_part some azurophil granule and has_part some tertiary granule and has_part some transcription factor PU.1 and has_part some CCAAT/enhancer-binding protein alpha and has_part some CCAAT/enhancer-binding protein epsilon and has_part some neutrophil gelatinase-associated lipocalin and has_part some lactotransferrin and has_part some myeloperoxidase and has plasma membrane part some integrin alpha-M and has plasma membrane part some alpha-(1,3)-fucosyltransferase FUT4 and has plasma membrane part some low affinity immunoglobulin gamma Fc region receptor III and has plasma membrane part some CD33 molecule and has plasma membrane part some signal transducer CD24 and has plasma membrane part some aminopeptidase N and lacks_plasma_membrane_part some fMet-Leu-Phe receptor
- metamyelocyte
- immature neutrophil
- has_part some reniform nucleus
- has_part some myeloperoxidase
- has_part some acidophilic cytoplasm
- has_part some tertiary granule
- has plasma membrane part some aminopeptidase N
- has plasma membrane part some alpha-(1,3)-fucosyltransferase FUT4
- has_part some heterochromatin
- has_part some azurophil granule
- has plasma membrane part some CD33 molecule
- develops from some neutrophilic myelocyte
- has_part some CCAAT/enhancer-binding protein epsilon
- lacks_plasma_membrane_part some fMet-Leu-Phe receptor
- has_part some CCAAT/enhancer-binding protein alpha
- has_part some neutrophil gelatinase-associated lipocalin
- has plasma membrane part some signal transducer CD24
- has plasma membrane part some low affinity immunoglobulin gamma Fc region receptor III
- has_part some transcription factor PU.1
- has_part some lactotransferrin