Terminology Service for NFDI4Health
multinucleated giant cell
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http://purl.obolibrary.org/obo/CL_0000647
A phagocytic cell formed by the fusion of macrophages, occurs in chronic inflammatory responses to persistent microorganism such as M.tuberculosis, component of granulomas. Sometimes used to refer to megakaryocytes. [ https://www.worldcat.org/search?q=bn%3A0702024783 https://www.worldcat.org/search?q=bn%3A0702022918 ]
Term info
Label
multinucleated giant cell
Synonyms
- Langerhans giant cell
- foreign body giant cell
- macrophage polykaryon
- multinucleate giant cell
- syncytial giant cell
comment
Role or process: Chronic infection, granulomatous inflammation. Consider also megakaryocyte (CL:0000556) as sometimes multinucleated giant cell is used to refer to this.
has obo namespace
cell
Term relations
Equivalent to:
- myeloid leukocyte and bearer of some multinucleate and participates_in some granuloma formation and participates_in some chronic inflammatory response
Subclass of:
- myeloid leukocyte
- multinucleate cell
- develops from some macrophage
- participates_in some granuloma formation
- participates_in some chronic inflammatory response