Terminology Service for NFDI4Health
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plasma cell

Go to external page http://purl.obolibrary.org/obo/CL_0000786

A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin. [ https://www.worldcat.org/search?q=bn%3A0721601464 https://www.worldcat.org/search?q=bn%3A0781735149 http://en.wikipedia.org/wiki/Plasma_cell http://www.ncbi.nlm.nih.gov/pubmed/20951740 http://www.ncbi.nlm.nih.gov/pubmed/19447676 http://www.ncbi.nlm.nih.gov/pubmed/20081059 http://purl.obolibrary.org/obo/go/references/0000031 http://www.ncbi.nlm.nih.gov/pubmed/20839338 ]

Term info

Label

plasma cell

Synonyms
  • plasma B cell
  • plasma B-cell
  • plasmacyte
  • plasmocyte
database cross reference
comment

Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive.

has related synonym

effector B cell, effector B-cell