Terminology Service for NFDI4Health
JSON

naive B cell

Go to external page http://purl.obolibrary.org/obo/CL_0000788

A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery. [ http://www.ncbi.nlm.nih.gov/pubmed/20839338 http://www.ncbi.nlm.nih.gov/pubmed/22343568 http://purl.obolibrary.org/obo/go/references/0000031 http://www.ncbi.nlm.nih.gov/pubmed/20933013 https://www.worldcat.org/search?q=bn%3A0781765196 http://www.ncbi.nlm.nih.gov/pubmed/19447676 http://www.ncbi.nlm.nih.gov/pubmed/20081059 ]

Term info

Label

naive B cell

Synonyms
  • naive B lymphocyte
  • naive B-cell
  • naive B-lymphocyte
comment

This cell type is compatible with the HIPC Lyoplate markers for 'naive B cell'. Per DSD: Naive B cells are also reportedly CD10-negative, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD25-negative, CD27-negative, CD34-negative, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD80-negative, CD81-positive, CD84-positive, CD86-negative, CD95-negative, CD138-negative, CD150-positive, CD184/CXCR4-positive, CD185/CXCR5-positive, CD196/CCR6-positive, CD200-positive, CD229-positive, CD243-positive, CD289-positive, CD290-positive, CD352-positive, MHCII/HLA-DR-positive, cadherin 9-positive, and sIgH-positive, Transcription factors: Pax5-positive, ETS1-positive, FOXO1A-positive, KLF4-positive, KLF9-positive, MiTF-positive, OBF1-positive, PLZF-positive, and SpiB-positive.