Terminology Service for NFDI4Health
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pro-B cell

Go to external page http://purl.obolibrary.org/obo/CL_0000826

A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs. [ http://www.ncbi.nlm.nih.gov/pubmed/16551251 http://www.ncbi.nlm.nih.gov/pubmed/12633665 https://www.worldcat.org/search?q=bn%3A0781735149 http://www.ncbi.nlm.nih.gov/pubmed/18432934 ]

Term info

Label

pro-B cell

Synonyms
  • pro-B lymphocyte
  • pro-B-cell
  • pro-B-lymphocyte
  • progenitor B cell
  • progenitor B lymphocyte
  • progenitor B-cell
  • progenitor B-lymphocyte
database cross reference
comment

Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative.

has broad synonym

pre-pro B cell

has related synonym

pre-B cell (Philadelphia nomenclature)