Terminology Service for NFDI4Health
marginal zone B cell
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http://purl.obolibrary.org/obo/CL_0000845
A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high. [ http://www.ncbi.nlm.nih.gov/pubmed/20933013 http://www.ncbi.nlm.nih.gov/pubmed/10933592 https://www.worldcat.org/search?q=bn%3A0781735149 http://en.wikipedia.org/wiki/Marginal-zone_B_cell ]
Term info
Label
marginal zone B cell
Synonyms
- MZ B cell
- MZ B lymphocyte
- MZ B-cell
- MZ B-lymphocyte
- marginal zone B lymphocyte
- marginal zone B-cell
- marginal zone B-lymphocyte
comment
MZ B cells are reportedly CD1-positive (mice), CD20-positive, CD48-positive, CD84-positive, CD150-positive, CD229-positive, and CD352-positive.
has obo namespace
cell
Term relations
Equivalent to:
- mature B cell and part of some marginal zone of spleen and has plasma membrane part some membrane-spanning 4-domains subfamily A member 1 and has plasma membrane part some complement receptor type 2 and capable of some defense response to bacterium and has_high_plasma_membrane_amount some IgM immunoglobulin complex and lacks_plasma_membrane_part some low affinity immunoglobulin epsilon Fc receptor and lacks_plasma_membrane_part some complement component C1q receptor
Subclass of:
- splenocyte
- mature B cell
- has plasma membrane part some complement receptor type 2
- capable of some defense response to bacterium
- has plasma membrane part some membrane-spanning 4-domains subfamily A member 1
- lacks_plasma_membrane_part some complement component C1q receptor
- part of some marginal zone of spleen
- has_high_plasma_membrane_amount some IgM immunoglobulin complex
- lacks_plasma_membrane_part some low affinity immunoglobulin epsilon Fc receptor