Terminology Service for NFDI4Health
classical monocyte
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http://purl.obolibrary.org/obo/CL_0000860
A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes. [ http://www.ncbi.nlm.nih.gov/pubmed/16322748 http://purl.obolibrary.org/obo/go/references/0000031 http://www.ncbi.nlm.nih.gov/pubmed/20628149 http://www.ncbi.nlm.nih.gov/pubmed/18303997 http://www.ncbi.nlm.nih.gov/pubmed/20870168 ]
Term info
Label
classical monocyte
Synonyms
- inflammatory monocyte
comment
Markers: CCR2+CXCCR1<low> (human, mouse, rat).
has obo namespace
cell
Term relations
Equivalent to:
- monocyte and capable of some monocyte chemotaxis and capable of some phagocytosis and capable of some inflammatory response and has_high_plasma_membrane_amount some C-C chemokine receptor type 2 and has_low_plasma_membrane_amount some CX3C chemokine receptor 1 and lacks_plasma_membrane_part some CD19 molecule and lacks_plasma_membrane_part some CD3 epsilon and lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1
Subclass of:
- material anatomical entity
- phagocyte
- monocyte
- lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1
- capable of some inflammatory response
- lacks_plasma_membrane_part some CD19 molecule
- lacks_plasma_membrane_part some CD3 epsilon
- has_high_plasma_membrane_amount some C-C chemokine receptor type 2
- capable of some monocyte chemotaxis
- has_low_plasma_membrane_amount some CX3C chemokine receptor 1
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