Terminology Service for NFDI4Health
non-classical monocyte
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http://purl.obolibrary.org/obo/CL_0000875
A type of monocyte characterized by low expression of CCR2, low responsiveness to monocyte chemoattractant CCL2/MCP1, low phagocytic activity, and decrease size relative to classical monocytes, but increased co-stimulatory activity. May also play a role in tissue repair. [ http://www.ncbi.nlm.nih.gov/pubmed/20870168 http://purl.obolibrary.org/obo/go/references/0000031 http://www.ncbi.nlm.nih.gov/pubmed/18303997 http://www.ncbi.nlm.nih.gov/pubmed/16322748 http://www.ncbi.nlm.nih.gov/pubmed/20628149 ]
Term info
Label
non-classical monocyte
Synonyms
- patrolling monocyte
- resident monocyte
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Markers: CCR2-CX3CCR1+ (human, mouse, rat); human: CD16+, CCR5+, CD32/FcgRII-high, MHCII+, CD86+; mouse: CD62L-Ly6C-.
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cell
Term relations
Equivalent to:
- monocyte and bearer of some decreased size and capable of some lymphocyte costimulation and has_completed some monocyte differentiation and has_high_plasma_membrane_amount some CX3C chemokine receptor 1 and lacks_plasma_membrane_part some CD19 molecule and lacks_plasma_membrane_part some CD3 epsilon and lacks_plasma_membrane_part some C-C chemokine receptor type 2 and lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1
Subclass of:
- material anatomical entity
- monocyte
- bearer of some decreased size
- lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1
- has_high_plasma_membrane_amount some CX3C chemokine receptor 1
- lacks_plasma_membrane_part some CD19 molecule
- lacks_plasma_membrane_part some CD3 epsilon
- capable of some lymphocyte costimulation
- has_completed some monocyte differentiation
- lacks_plasma_membrane_part some C-C chemokine receptor type 2
- develops from some intermediate monocyte