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naive thymus-derived CD4-positive, alpha-beta T cell

http://purl.obolibrary.org/obo/CL_0000895

An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low. [ http://purl.obolibrary.org/obo/go/references/0000031 http://www.immgen.org/index_content.html http://www.ncbi.nlm.nih.gov/pubmed/19100699 http://www.ncbi.nlm.nih.gov/pubmed/22343568 ]

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Term info

Label

naive thymus-derived CD4-positive, alpha-beta T cell

Synonyms

T.4Nve.Sp
Th0
naive thymus-derived CD4-positive, alpha-beta T lymphocyte
naive thymus-derived CD4-positive, alpha-beta T-cell
naive thymus-derived CD4-positive, alpha-beta T-lymphocyte

comment

These cells have not been exposed to antigen following thymic T-cell selection; found in blood and secondary lymphoid organs. This cell type is compatible with the HIPC Lyoplate markers for 'naive CD4+ T cell', but includes additional markers known to be expressed on naive CD4+ T cells.

has broad synonym

naive CD4+ T cell

has obo namespace

cell

Term relations

Equivalent to:

CD4-positive, alpha-beta T cell and has plasma membrane part some receptor-type tyrosine-protein phosphatase C isoform CD45RA and has plasma membrane part some C-C chemokine receptor type 7 and has plasma membrane part some interleukin-7 receptor subunit alpha and has_high_plasma_membrane_amount some L-selectin and has_low_plasma_membrane_amount some CD44 molecule and lacks_plasma_membrane_part some interleukin-2 receptor subunit alpha

Subclass of:

Related from:

develops_from

activated CD4-positive, alpha-beta T cell