Terminology Service for NFDI4Health
naive thymus-derived CD8-positive, alpha-beta T cell
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http://purl.obolibrary.org/obo/CL_0000900
A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low. [ http://purl.obolibrary.org/obo/go/references/0000031 https://www.worldcat.org/search?q=bn%3A0781735149 http://www.ncbi.nlm.nih.gov/pubmed/22343568 http://www.immgen.org/index_content.html ]
Term info
Label
naive thymus-derived CD8-positive, alpha-beta T cell
Synonyms
- naive thymus-dervied CD8-positive, alpha-beta T lymphocyte
- naive thymus-dervied CD8-positive, alpha-beta T-cell
- naive thymus-dervied CD8-positive, alpha-beta T-lymphocyte
comment
This cell traffics in secondary lymphoid organs and blood. This cell type is compatible with the HIPC Lyoplate markers for 'naive CD8+ T cell', but includes additional markers known to be expressed on naive CD8+ T cells.
has broad synonym
naive CD8+ T cell
has narrow synonym
T.8Nve.Sp
has obo namespace
cell
Term relations
Equivalent to:
- CD8-positive, alpha-beta T cell and has plasma membrane part some receptor-type tyrosine-protein phosphatase C isoform CD45RA and has plasma membrane part some C-C chemokine receptor type 7 and has plasma membrane part some interleukin-7 receptor subunit alpha and has_high_plasma_membrane_amount some L-selectin and has_low_plasma_membrane_amount some CD44 molecule and lacks_plasma_membrane_part some interleukin-2 receptor subunit alpha
Subclass of:
- naive T cell
- CD8-positive, alpha-beta T cell
- develops from some mature CD8 single-positive thymocyte
- lacks_plasma_membrane_part some interleukin-2 receptor subunit alpha
Related from: