Terminology Service for NFDI4Health
T follicular helper cell
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http://purl.obolibrary.org/obo/CL_0002038
A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that expresses is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production. [ http://www.ncbi.nlm.nih.gov/pubmed/20107805 http://www.ncbi.nlm.nih.gov/pubmed/22043829 http://www.ncbi.nlm.nih.gov/pubmed/19855402 ]
Term info
Label
T follicular helper cell
Synonyms
- T(FH)
- Tfh
created by
tmeehan
creation date
2009-10-29T04:01:27Z
has obo namespace
cell
has related synonym
follicular helper T-cell, follicular B helper T cell, follicular T cell, follicular T-helper cell, follicular T-cell, follicular helper T cell
Term relations
Equivalent to:
- CD4-positive helper T cell and has_part some B-cell lymphoma 6 protein and has plasma membrane part some C-X-C chemokine receptor type 5 and has plasma membrane part some inducible T-cell costimulator and has plasma membrane part some programmed cell death protein 1 and capable of some positive regulation of isotype switching and capable of some positive regulation of immunoglobulin secretion and lacks_plasma_membrane_part some C-C chemokine receptor type 7
Subclass of:
- CD4-positive helper T cell
- has_part some B-cell lymphoma 6 protein
- has plasma membrane part some programmed cell death protein 1
- capable of some positive regulation of immunoglobulin secretion
- lacks_plasma_membrane_part some C-C chemokine receptor type 7
- capable of some positive regulation of isotype switching
- has plasma membrane part some inducible T-cell costimulator
- has plasma membrane part some C-X-C chemokine receptor type 5