relationship type change: differentiates_from lateral plate mesoderm (AAO:0010574) CHANGED TO: develops_from lateral plate mesoderm (UBERON:0003081)[AAO]

Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" DOI:10.1101/gad.1485706

Blood pumping organ composed of four chambers: sinus venosus, atrium, cardiac ventricle and bulbus arteriosus.[TAO], Part of the circulatory system responsible for pumping blood; composed of three chambers--two atria and one ventricle.[AAO]

branchial heart

uberon

Herz@de, cardium

cardiac

As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[well established][VHOG]

UBERON:0000948

• conducting system of heart
• coronary vessel
• heart layer
• cardiac septum
• cardiac atrium
• cardiac ventricle

• cardiovascular system

• cardiac nerve plexus

• left cardiac chamber

• right cardiac chamber

• pulmonary trunk

• pericardial fat

• artery
• outflow tract

• epicardium
• heart elastic tissue
• fibrous ring of heart
• heart valve cell
• cardiac muscle tissue
• mesentery of heart
• heart vasculature
• cardiac endothelial cell
• cardiac glial cell
• cardiac neuron
• cardiac chamber
• outflow tract
• cardiac mesenchyme
• bulbus cordis
• heart endothelium
• coronary vessel
• heart layer
• fibroblast of cardiac tissue
• cardiac septum
• atrioventricular region