Terminology Service for NFDI4Health
pronephric glomerulus
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http://purl.obolibrary.org/obo/UBERON_0004739
The glomus forms from the splanchnic intermediate mesoderm and is the vascularized filtration unit, filtering the blood before it enters the tubules. The glomus is external to the nephron and extends over more than one body segment. [ http://www.ncbi.nlm.nih.gov/pubmed/10572058 http://www.ncbi.nlm.nih.gov/pubmed/15647339 https://doi.org/10.1371/journal.pone.0099864 http://www.ncbi.nlm.nih.gov/pubmed/9268568 http://amigo.geneontology.org/amigo/term/GO:0072013 ]
Term info
Label
pronephric glomerulus
Synonyms
- glomerulus of pronephros
curator note
a glomus differs from a glomerulus in that each vascular glomus services several tubules
external definition
Paired highly vascularized portion of the pronephros. Left and right glomeruli are fused at the midline. Begins to function between 40 and 48hpf. Drummond, 2000.[TAO]
external ontology notes
GO treats glomus and pronephric glomerulus differently
has alternative id
UBERON:0004191
has narrow synonym
glomus
has obo namespace
uberon
has related synonym
corpuscle, pronephric glomus, pronephric glomeruli, pronephric glomera, glomera
homology notes
The teleost pronephros shares many essential features with the amphibian pronephros including its derivation from mesoderm associated with the coelom and the derivation of the glomerular blood supply from the medial dorsal aorta. However, unlike the pronephros of amphibians, which have an external glomus and tubules with nephrostomes open to the coelom, the mature teleost pronephros has no connection to the body cavity and instead functions as a closed system (reference 1); This variation in nephron types [with external glomeruli that open into the coelom and with internal glomeruli that do not connect with the coelom] and their pattern of distribution suggest an evolutionary sequence. Ancestral craniates probably had an external glomerulus and nephrostomes, as do the first few to develop in very primitive craniates. (...) The mechanism would become more efficient as the coelomic recess into which each glomerulus discharged became a part of the tubule, that is, grew around the glomerulus as a renal capsule. The glomerulus becomes internal. The nephrostomes were lost during subsequent evolution, leaving the type of renal tubule found in most vertebrates (reference 2).[well established][VHOG]
id
UBERON:0004739