Terminology Service for NFDI4Health
circumventricular organ
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http://purl.obolibrary.org/obo/UBERON_0005408
Any of any of the secretory or sensory organs located in the brain region around or in relation to the ventricular system that are characterized by extensive vasculature and a lack of a normal blood brain barrier (BBB) and allow for the linkage between the central nervous system and peripheral blood flow. [ ]
Term info
Label
circumventricular organ
Synonyms
- CVO
- circumventricular organ
- circumventricular organ of neuraxis
Subsets
pheno_slim
depicted by
http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray734.png
has obo namespace
uberon
id
UBERON:0005408
structure notes
CVOs contain neural tissue and are an integral part of neuroendocrine function; all of the CVOs, besides the subcommissural organ, contain extensive vasculature and fenestrated capillaries which leads to a leaky BBB at the site of the organs; the lack of a BBB allows CVOs to act as an alternative route for peptides and hormones in the neural tissue to the peripheral blood stream, while still protecting it from toxic substances
taxon notes
All vertebrates possess at least 4 circumventricular organs (including the hypothalamus) which can monitor the contents of the cerebrospinal fluid and secrete additional substances into it. (Butler, 1996, p. 330)