c is_manufactured_by o means that there was a process p in which c was built in which a person, or set of people or machines did the work(bore the "Manufacturer Role", and those people/and or machines were members or of directed by the organization to do this.

is_manufactured_by

http://www.affymetrix.com/products/arrays/specific/hgu133.affx is_manufactered_by http://www.affymetrix.com/ (if we decide to use these URIs for the actual entities)

http://purl.obolibrary.org/obo/IAO_0000123

http://purl.obolibrary.org/obo/obi.owl

Liju Fan,Alan Ruttenberg