Terminology Service for NFDI4Health
macrophage
Go to external page
http://purl.obolibrary.org/obo/CL_0000235
Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid.
Term info
Label
macrophage
definition
A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.
has exact synonym
histiocyte
has obo namespace
cell
imported from
http://purl.obolibrary.org/obo/cl.owl
Term relations
Equivalent to:
- myeloid leukocyte and capable of some antigen processing and presentation of peptide or polysaccharide antigen via MHC class II and capable of some phagocytosis and capable of some pseudopodium organization