Terminology Service for NFDI4Health

keratinocyte

Go to external page http://purl.obolibrary.org/obo/CL_0000312


Keratinocytes are reportedly CDw210a-negative, CDw210b-positive, CD281-positive, CD282-positive, CD285-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive.

An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.

Skin cell, of the keratinized layer of epidermis: its characteristic intermediate filament protein is cytokeratin.

Term info

Label

keratinocyte

Synonyms
  • malpighian cell
database cross reference
definition

An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.

definition source

BTO:0000667, CL:0000312

has exact synonym

malpighian cell, keratinized cell of epidermis

has alternative id

CL:0002185

imported from

http://purl.obolibrary.org/obo/cl.owl

see also

URI: http://www.ebi.ac.uk/cellline#keratinocyte, EFO_URI: http://www.ebi.ac.uk/efo/EFO_0000560

term editor

James Malone