Terminology Service for NFDI4Health
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Langerhans cell

Go to external page http://purl.obolibrary.org/obo/CL_0000453

Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID:19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis.

Term info

Label

Langerhans cell

database cross reference
definition

Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus.

has exact synonym

LC, Langerhans' cell

imported from

http://purl.obolibrary.org/obo/cl.owl