Terminology Service for NFDI4Health
granulocyte monocyte progenitor cell
Go to external page
http://purl.obolibrary.org/obo/CL_0000557
Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.
Term info
Label
granulocyte monocyte progenitor cell
definition
A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1.
has exact synonym
granulocyte/monocyte progenitor, colony forming unit granulocyte macrophage, granulocyte/monocyte precursor, CFU-GM, GMP, granulocyte-macrophage progenitor
has broad synonym
CFU-C , Colony forming unit in culture
has obo namespace
cell
imported from
http://purl.obolibrary.org/obo/cl.owl
Term relations
Equivalent to:
- hematopoietic oligopotent progenitor cell and part of some bone marrow and has part some transcription factor PU.1 and has part some CCAAT/enhancer-binding protein alpha and has plasma membrane part some interleukin-3 receptor class 2 alpha chain and capable of some macrophage differentiation and capable of some granulocyte differentiation and lacks_part some erythroid transcription factor and lacks_part some endothelial transcription factor GATA-2
Subclass of:
- bone marrow hematopoietic cell
- hematopoietic oligopotent progenitor cell
- material anatomical entity
- progenitor cell
- myeloid cell
- CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
- lacks_part some erythroid transcription factor
- capable of some granulocyte differentiation
- capable of some macrophage differentiation
- has part some transcription factor PU.1
- has plasma membrane part some interleukin-3 receptor class 2 alpha chain
- has part some CCAAT/enhancer-binding protein alpha
- lacks_part some endothelial transcription factor GATA-2