Terminology Service < Semantic Lookup Platform

plasma cell

http://purl.obolibrary.org/obo/CL_0000786

Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive.

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Term info

Label

plasma cell

database cross reference

definition

A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin.

has exact synonym

plasma B-cell, plasma B cell, plasmocyte, plasmacyte

has obo namespace

cell

has related synonym

effector B cell, effector B-cell

imported from

http://purl.obolibrary.org/obo/cl.owl

Term relations

Equivalent to:

antibody secreting cell and has part some cartwheel heterochromatin and has part some Golgi apparatus and has plasma membrane part some syndecan-1 and lacks_plasma_membrane_part some immunoglobulin complex and lacks_plasma_membrane_part some MHC class II protein complex and lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1

Subclass of:

Related from:

derives from

immortal plasma cell line cell