Terminology Service < Semantic Lookup Platform

DN4 thymocyte

http://purl.obolibrary.org/obo/CL_0000808

Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain. There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'.

Tree view

Term info

Label

DN4 thymocyte

definition

A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive.

has exact synonym

DN4 immature T cell, double negative 4, DN4 alpha-beta immature T-lymphocyte, DN4 immature T-cell, DN4 alpha-beta immature T lymphocyte, DN4 cell, T.DN4.th

has broad synonym

early cortical thymocyte

has obo namespace

cell

imported from

http://purl.obolibrary.org/obo/cl.owl

Term relations

Equivalent to:

thymocyte and has plasma membrane part some pre-T cell receptor complex and lacks_plasma_membrane_part some CD4 molecule and lacks_plasma_membrane_part some CD44 molecule and lacks_plasma_membrane_part some interleukin-2 receptor subunit alpha and lacks_plasma_membrane_part some T cell receptor co-receptor CD8

Subclass of:

Related from:

develops from

immature single positive thymocyte