Terminology Service for NFDI4Health
pro-B cell
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http://purl.obolibrary.org/obo/CL_0000826
Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative.
Term info
Label
pro-B cell
definition
A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs.
has exact synonym
pro-B lymphocyte, progenitor B lymphocyte, pro-B-cell, pro-B-lymphocyte, progenitor B cell, progenitor B-lymphocyte, progenitor B-cell
has broad synonym
pre-pro B cell
has obo namespace
cell
has related synonym
pre-B cell (Philadelphia nomenclature)
imported from
http://purl.obolibrary.org/obo/cl.owl
Term relations
Equivalent to:
- lymphoid lineage restricted progenitor cell and has part some paired box protein PAX-5 and has part some DNA nucleotidylexotransferase and participates in some immunoglobulin V(D)J recombination