Terminology Service < Semantic Lookup Platform

mast cell progenitor

http://purl.obolibrary.org/obo/CL_0000831

MCP are CD16-positive, CD32-positive, CD34-positive, CD45-positive, integrin beta-7-positive, and lin-negative (CD2, CD3e, CD4, CD5, CD8a, CD14, CD19, CD20, CD27, integrin alpha-M, ly6c, ly6g, NCAM-1, and ter119). These cells also express the transcription factors GATA-1, GATA-2, and MITF, but not C/EBPa.

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Term info

Label

mast cell progenitor

definition

A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative.

has exact synonym

MCP

has obo namespace

cell

has related synonym

colony forming unit mast cell, CFU-MC, CFU-Mast

imported from

http://purl.obolibrary.org/obo/cl.owl

Term relations

Equivalent to:

myeloid lineage restricted progenitor cell and has part some erythroid transcription factor and has part some endothelial transcription factor GATA-2 and has plasma membrane part some CD9 molecule and has plasma membrane part some transmembrane emp24 domain-containing protein 1 and capable of some mast cell differentiation and has_high_plasma_membrane_amount some integrin beta-7 and has_low_plasma_membrane_amount some mast/stem cell growth factor receptor and has_low_plasma_membrane_amount some high affinity immunoglobulin epsilon receptor subunit alpha and lacks_part some CCAAT/enhancer-binding protein alpha and lacks_plasma_membrane_part some CD19 molecule and lacks_plasma_membrane_part some CD4 molecule and lacks_plasma_membrane_part some integrin alpha-M and lacks_plasma_membrane_part some CD3 epsilon and lacks_plasma_membrane_part some neural cell adhesion molecule 1 and lacks_plasma_membrane_part some CD2 molecule and lacks_plasma_membrane_part some T-cell surface glycoprotein CD8 alpha chain and lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1 and lacks_plasma_membrane_part some T-cell surface glycoprotein CD5 and lacks_plasma_membrane_part some CD14 molecule and lacks_plasma_membrane_part some CD27 molecule and lacks_plasma_membrane_part some lymphocyte antigen 6G and lacks_plasma_membrane_part some lymphocyte antigen 6A-2/6E-1 and lacks_plasma_membrane_part some lymphocyte antigen 6C2 and lacks_plasma_membrane_part some lymphocyte antigen 76 (mouse)

Subclass of:

Related from:

develops from

mast cell