Terminology Service for NFDI4Health
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cell line immortalization

Go to external page http://purl.obolibrary.org/obo/OBI_0000877

A immortalizing genetic transformation of an existing population of cell line cells is required as part of this process, as are additional steps for selecting and propagating the cells output form this process into a cell line.

Term info

Label

cell line immortalization

Synonyms
  • 'establishing immortal cell line through directed genetic modification'
definition

an establishing cell line process whereby a mortal cell line is intentionally genetically modified to be capable of indefinite propagation and re-established as a new immortal cell line

editor note

4-20-13 MHB: This class was repositioned as a child of 'establishing cell line', based on the existing definition ("the planned process of experimentally creating a cell line which is capable of dividing indefinitely in vitro"), and examples and other annotations indicating the intent to describe a process through which a new immortal cell line is established from an existing mortal cell line using genetic modification techniques. The definition above was modified to clarify this perspective.

editor preferred label

cell line immortalization

example of usage

Production of a cell line for the purposes of experimentation e.g. EBV transformation of PBMs

has curation status

http://purl.obolibrary.org/obo/IAO_0000123

imported from

http://purl.obolibrary.org/obo/obi.owl

term editor

Bjoern Peters