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amyotrophic lateral sclerosis

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A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts (MeSH).

A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)

An autosomal dominant inherited form of amyloidosis.

Term info

Label

amyotrophic lateral sclerosis

Synonyms
  • ALS
  • ALS (Amyotrophic Lateral Sclerosis)
  • AMYOTROPHIC SCLEROSIS
  • Amyotrophic Lateral Sclerosis, Guam Form
  • Amyotrophic lateral sclerosis (disorder)
  • Dementia With Amyotrophic Lateral Sclerosis
  • Disease, Lou-Gehrigs
  • GEHRIGS DIS
  • Gehrig Disease
  • Gehrigs Disease
  • Guam Form of Amyotrophic Lateral Sclerosis
  • LOU GEHRIG DIS
  • LOU GEHRIGS DIS
  • Lateral Scleroses, Amyotrophic
  • Lou Gehrig Disease
  • Lou Gehrig's disease
  • MOTOR NEURON DIS AMYOTROPHIC LATERAL SCLEROSIS
  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis
  • Motor neuron disease, bulbar
  • amyotrophic lateral sclerosis
definition source

GeneRIF:12125045, GeneRIF:11854284, GeneRIF:14676054, GeneRIF:15837590, GeneRIF:14734542, GeneRIF:15509539, GeneRIF:15106121, GeneRIF:11854285, GeneRIF:14985749, GeneRIF:12843244, GeneRIF:15465081, GeneRIF:12437574, GeneRIF:12707786, ICD9:335.20, GeneRIF:11996514, GeneRIF:15488469, GeneRIF:12875980, GeneRIF:11943600, GeneRIF:15109247, GeneRIF:15691826, GeneRIF:12915461, GeneRIF:15037546, GeneRIF:15076751, GeneRIF:11675877, GeneRIF:12866199, GeneRIF:15623718, GeneRIF:14970233, GeneRIF:11951178, GeneRIF:12730211, GeneRIF:15388334, NCIt:C34373, GeneRIF:15829169, GeneRIF:12475980, GeneRIF:16020530, GeneRIF:12230304, GeneRIF:15313203, GeneRIF:15184633, GeneRIF:15264227, GeneRIF:15069187, GeneRIF:15634772, GeneRIF:15789135, GeneRIF:15048885, GeneRIF:15326253, MSH:D000690, GeneRIF:15978558, GeneRIF:12770687, GeneRIF:12870272, GeneRIF:15330338, GeneRIF:14596848, GeneRIF:12694394, GeneRIF:12480087, GeneRIF:12217886, DOID:332, GeneRIF:15233913, SNOMEDCT:86044005, GeneRIF:14506936, GeneRIF:12528821, GeneRIF:14597108, GeneRIF:15652414, GeneRIF:16114275, GeneRIF:12138710, GeneRIF:12270696, GeneRIF:12847526, GeneRIF:14991384, GeneRIF:12659845, GeneRIF:14989597, GeneRIF:15094483, GeneRIF:12502789, GeneRIF:15126567, GeneRIF:12127151, GeneRIF:12614934, GeneRIF:12972170, NIFSTD:birnlex_12566, GeneRIF:15657392, GeneRIF:12441104, GeneRIF:12458194, GeneRIF:13129803, GeneRIF:15568021, GeneRIF:12235108, GeneRIF:12442272, GeneRIF:15033789, GeneRIF:15030390, GeneRIF:15006704, GeneRIF:15019581, GeneRIF:12679596, GeneRIF:12677446, GeneRIF:12644909, GeneRIF:15753080, GeneRIF:14511332, GeneRIF:14675609, GeneRIF:12210393, GeneRIF:15546588, GeneRIF:12393885, GeneRIF:12641746, GeneRIF:15910777, GeneRIF:14978393, GeneRIF:14642651, GeneRIF:15475574, GeneRIF:15557516, GeneRIF:15672551, GeneRIF:11860274, GeneRIF:12039658, GeneRIF:12584731, GeneRIF:12446576, GeneRIF:15657798, GeneRIF:12153483, GeneRIF:15350647, GeneRIF:16005901, GeneRIF:11991808, GeneRIF:15776280, GeneRIF:12783432, GeneRIF:13678668, GeneRIF:12448348

see also

URI: http://www.ebi.ac.uk/cellline#amyotrophic_lateral_sclerosis

term editor

Tomasz Adamusiak, James Malone