Simon Jupp
Johan Lundin
Claudia Lukas
Beate Neumann
Frauke Neff
Thomas Walter
Cellular Microscopy Phenotype Ontology
cmpo
Bran Herpers
Jean-Karim Heriche
Gabriella Rustici
Jennifer L. Rohn
Zvi Kam
James Malone
definition source
CMPO subset
cmpo
Grouping classes that can be excluded
Term not to be used for direct annotation
Term not to be used for direct manual annotation
Aspergillus GO slim
Candida GO slim
ChEMBL protein targets summary
Generic GO slim
GOA and proteome slim
Metagenomics GO slim
PIR GO slim
Plant GO slim
Fission yeast GO slim
synapse GO slim
Viral GO slim
Yeast GO slim
Prokaryotic GO subset
Catalytic activity terms in need of attention
Systematic synonym
Terms created by TermGenie that do not follow a template and require additional vetting by editors
Viral overhaul terms
subset_property
has_alternative_id
has_broad_synonym
database_cross_reference
has_exact_synonym
has_narrow_synonym
has_obo_namespace
has_related_synonym
has_scope
in_subset
shorthand
BFO:0000050
OBO_REL:part_of
part_of
part_of
has_part
BFO:0000066
external
occurs_in
occurs_in
occurs in
quality
towards
Relation binding a relational quality or disposition to the relevant type of entity.
s depends on
inheres_in
bearer of
participates in
located in
RO:0002092
external
happens_during
happens_during
happens_during
RO:0002093
external
ends_during
ends_during
ends_during
RO:0002211
external
regulates
regulates
regulates
RO:0002212
external
negatively_regulates
negatively_regulates
negatively regulates
RO:0002213
external
positively_regulates
positively_regulates
positively regulates
transports or maintains localization of
has target end location
q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
quality
decreased_in_magnitude_relative_to
This relation is used to determine the 'directionality' of relative qualities such as 'decreased strength', relative to the parent type, 'strength'.
decreased_in_magnitude_relative_to
q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
PATOC:CJM
q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
quality
different_in_magnitude_relative_to
different_in_magnitude_relative_to
q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
PATOC:CJM
q1 directly_associated_with q2 iff q1 is dependent on q2, and the magnitude of q1 increases if the magnitude of q2 is increased, or the magnitude of q1 decreases if the magnitude of q2 is decreased. The relationship is not necessarily linear.
cjm
2009-08-26T02:50:08Z
quality
directly_associated_with
Example: 'Lewy bodies increased number related to dystrophic neurite increased number' (from annotation of PMID:8740227 in http://ccdb.ucsd.edu/1.0/NDPO.owl#ndpo_404). Here the increase in the number of lewy bodies is directly_associated_with the increase in the number of dystrophic neurites.
Association is weaker than correlation or proportionality. These relations may be later added to PATO.
directly_associated_with
q1 directly_associated_with q2 iff q1 is dependent on q2, and the magnitude of q1 increases if the magnitude of q2 is increased, or the magnitude of q1 decreases if the magnitude of q2 is decreased. The relationship is not necessarily linear.
PATOC:cjm
Wikipedia:Association_(statistics)
s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2.
quality
has_cross_section
Example: a spherical object has the quality of being spherical, and the spherical quality has_cross_section round.
has_cross_section
s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2.
PATOC:CJM
quality
has_dividend_quality
has_dividend_quality
quality
has_divisor_quality
has_divisor_quality
quality
has_ratio_quality
has_ratio_quality
q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
quality
increased_in_magnitude_relative_to
This relation is used to determine the 'directionality' of relative qualities such as 'increased strength', relative to the parent type, 'strength'.
increased_in_magnitude_relative_to
q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
PATOC:CJM
q1 inversely_associated_with q2 iff q1 is dependent on q2, and the magnitude of q1 decreases if the magnitude of q2 is increased, or the magnitude of q1 increases if the magnitude of q2 is decreased. The relationship is not necessarily linear.
cjm
2009-08-26T02:50:24Z
quality
inversely_associated_with
Association is weaker than correlation or proportionality. These relations may be later added to PATO.
inversely_associated_with
q1 inversely_associated_with q2 iff q1 is dependent on q2, and the magnitude of q1 decreases if the magnitude of q2 is increased, or the magnitude of q1 increases if the magnitude of q2 is decreased. The relationship is not necessarily linear.
PATOC:cjm
Wikipedia:Association_(statistics)
q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e.
quality
reciprocal_of
There are frequently two ways to state the same thing: we can say 'spermatocyte lacks asters' or 'asters absent from spermatocyte'. In this case the quality is 'lacking all parts of type' - it is a (relational) quality of the spermatocyte, and it is with respect to instances of 'aster'. One of the popular requirements of PATO is that it continue to support 'absent', so we need to relate statements which use this quality to the 'lacking all parts of type' quality.
reciprocal_of
q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e.
PATOC:CJM
q1 similar_in_magnitude_relative_to q2 if and only if magnitude(q1) =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
quality
similar_in_magnitude_relative_to
similar_in_magnitude_relative_to
q1 similar_in_magnitude_relative_to q2 if and only if magnitude(q1) =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
PATOC:CJM
has accuracy
has qualifier
protein
polypeptide
deoxyribonucleic acid
molecular entity
nucleic acid
macromolecule
A cell that is maintained or propagated in a controlled artificial environment for use in an investigation.
cell in vitro
The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
GO:0016359
mitotic chromosome segregation
mitotic sister-chromatid adhesion release
biological_process
GO:0000070
mitotic sister chromatid segregation
The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
GOC:ai
GOC:jl
The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis.
Reactome:REACT_101162
Reactome:REACT_1590
Reactome:REACT_29795
Reactome:REACT_34060
Reactome:REACT_78665
Reactome:REACT_78866
Reactome:REACT_83686
Reactome:REACT_91654
Reactome:REACT_93384
Reactome:REACT_93574
G1 phase of mitotic cell cycle
biological_process
GO:0000080
Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
mitotic G1 phase
The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis.
GOC:mtg_cell_cycle
Reactome:REACT_101162
G1 Phase, Bos taurus
Reactome:REACT_1590
G1 Phase, Homo sapiens
Reactome:REACT_29795
G1 Phase, Taeniopygia guttata
Reactome:REACT_34060
G1 Phase, Canis familiaris
Reactome:REACT_78665
G1 Phase, Gallus gallus
Reactome:REACT_78866
G1 Phase, Sus scrofa
Reactome:REACT_83686
G1 Phase, Danio rerio
Reactome:REACT_91654
G1 Phase, Mus musculus
Reactome:REACT_93384
G1 Phase, Rattus norvegicus
Reactome:REACT_93574
G1 Phase, Xenopus tropicalis
The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle.
Reactome:REACT_105829
Reactome:REACT_108550
Reactome:REACT_110039
Reactome:REACT_28988
Reactome:REACT_32013
Reactome:REACT_34043
Reactome:REACT_78838
Reactome:REACT_78845
Reactome:REACT_81914
Reactome:REACT_82813
Reactome:REACT_85811
Reactome:REACT_89318
Reactome:REACT_899
Reactome:REACT_92500
Reactome:REACT_92759
Reactome:REACT_95174
Reactome:REACT_96081
Reactome:REACT_97603
Reactome:REACT_99645
S phase of mitotic cell cycle
S-phase of mitotic cell cycle
biological_process
GO:0000084
Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
mitotic S phase
The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle.
GOC:mtg_cell_cycle
Reactome:REACT_105829
S Phase, Caenorhabditis elegans
Reactome:REACT_108550
S Phase, Rattus norvegicus
Reactome:REACT_110039
S Phase, Schizosaccharomyces pombe
Reactome:REACT_28988
S Phase, Taeniopygia guttata
Reactome:REACT_32013
S Phase, Mycobacterium tuberculosis
Reactome:REACT_34043
S Phase, Oryza sativa
Reactome:REACT_78838
S Phase, Plasmodium falciparum
Reactome:REACT_78845
S Phase, Xenopus tropicalis
Reactome:REACT_81914
S Phase, Saccharomyces cerevisiae
Reactome:REACT_82813
S Phase, Arabidopsis thaliana
Reactome:REACT_85811
S Phase, Sus scrofa
Reactome:REACT_89318
S Phase, Drosophila melanogaster
Reactome:REACT_899
S Phase, Homo sapiens
Reactome:REACT_92500
S Phase, Mus musculus
Reactome:REACT_92759
S Phase, Canis familiaris
Reactome:REACT_95174
S Phase, Gallus gallus
Reactome:REACT_96081
S Phase, Dictyostelium discoideum
Reactome:REACT_97603
S Phase, Danio rerio
Reactome:REACT_99645
S Phase, Bos taurus
The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis.
Reactome:REACT_105223
Reactome:REACT_105307
Reactome:REACT_106415
Reactome:REACT_106836
Reactome:REACT_1915
Reactome:REACT_28975
Reactome:REACT_85928
Reactome:REACT_96332
G2 phase of mitotic cell cycle
biological_process
GO:0000085
Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
mitotic G2 phase
The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis.
GOC:mtg_cell_cycle
Reactome:REACT_105223
G2 Phase, Mus musculus
Reactome:REACT_105307
G2 Phase, Canis familiaris
Reactome:REACT_106415
G2 Phase, Xenopus tropicalis
Reactome:REACT_106836
G2 Phase, Bos taurus
Reactome:REACT_1915
G2 Phase, Homo sapiens
Reactome:REACT_28975
G2 Phase, Rattus norvegicus
Reactome:REACT_85928
G2 Phase, Sus scrofa
Reactome:REACT_96332
G2 Phase, Danio rerio
The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
Reactome:REACT_100942
Reactome:REACT_103766
Reactome:REACT_107882
Reactome:REACT_114616
Reactome:REACT_2203
Reactome:REACT_28929
Reactome:REACT_30388
Reactome:REACT_34062
Reactome:REACT_77778
Reactome:REACT_83880
Reactome:REACT_87036
Reactome:REACT_87230
Reactome:REACT_87807
Reactome:REACT_88018
Reactome:REACT_88369
Reactome:REACT_92702
mitotic G2/M transition
biological_process
GO:0000086
G2/M transition of mitotic cell cycle
The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
GOC:mtg_cell_cycle
Reactome:REACT_100942
G2/M Transition, Danio rerio
Reactome:REACT_103766
G2/M Transition, Schizosaccharomyces pombe
Reactome:REACT_107882
G2/M Transition, Sus scrofa
Reactome:REACT_114616
G2/M Transition, Arabidopsis thaliana
Reactome:REACT_2203
G2/M Transition, Homo sapiens
Reactome:REACT_28929
G2/M Transition, Xenopus tropicalis
Reactome:REACT_30388
G2/M Transition, Gallus gallus
Reactome:REACT_34062
G2/M Transition, Mus musculus
Reactome:REACT_77778
G2/M Transition, Taeniopygia guttata
Reactome:REACT_83880
G2/M Transition, Drosophila melanogaster
Reactome:REACT_87036
G2/M Transition, Saccharomyces cerevisiae
Reactome:REACT_87230
G2/M Transition, Canis familiaris
Reactome:REACT_87807
G2/M Transition, Dictyostelium discoideum
Reactome:REACT_88018
G2/M Transition, Caenorhabditis elegans
Reactome:REACT_88369
G2/M Transition, Rattus norvegicus
Reactome:REACT_92702
G2/M Transition, Bos taurus
A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle.
Reactome:REACT_105412
Reactome:REACT_107095
Reactome:REACT_109059
Reactome:REACT_29488
Reactome:REACT_33490
Reactome:REACT_82055
Reactome:REACT_87132
Reactome:REACT_88263
Reactome:REACT_910
Reactome:REACT_92998
Reactome:REACT_93131
Reactome:REACT_93566
Reactome:REACT_93720
Reactome:REACT_94536
M phase of mitotic cell cycle
M-phase of mitotic cell cycle
biological_process
GO:0000087
Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
mitotic M phase
A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle.
GOC:mtg_cell_cycle
Reactome:REACT_105412
M Phase, Mus musculus
Reactome:REACT_107095
M Phase, Dictyostelium discoideum
Reactome:REACT_109059
M Phase, Saccharomyces cerevisiae
Reactome:REACT_29488
M Phase, Canis familiaris
Reactome:REACT_33490
M Phase, Caenorhabditis elegans
Reactome:REACT_82055
M Phase, Rattus norvegicus
Reactome:REACT_87132
M Phase, Bos taurus
Reactome:REACT_88263
M Phase, Xenopus tropicalis
Reactome:REACT_910
M Phase, Homo sapiens
Reactome:REACT_92998
M Phase, Danio rerio
Reactome:REACT_93131
M Phase, Schizosaccharomyces pombe
Reactome:REACT_93566
M Phase, Gallus gallus
Reactome:REACT_93720
M Phase, Drosophila melanogaster
Reactome:REACT_94536
M Phase, Taeniopygia guttata
The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.
Reactome:REACT_100605
Reactome:REACT_102122
Reactome:REACT_105127
Reactome:REACT_106058
Reactome:REACT_28443
Reactome:REACT_28607
Reactome:REACT_32677
Reactome:REACT_765
Reactome:REACT_79474
Reactome:REACT_80300
Reactome:REACT_83888
Reactome:REACT_90347
Reactome:REACT_90481
biological_process
GO:0000088
Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
mitotic prophase
Reactome:REACT_100605
Mitotic Prophase, Saccharomyces cerevisiae
Reactome:REACT_102122
Mitotic Prophase, Mus musculus
Reactome:REACT_105127
Mitotic Prophase, Danio rerio
Reactome:REACT_106058
Mitotic Prophase, Drosophila melanogaster
Reactome:REACT_28443
Mitotic Prophase, Taeniopygia guttata
Reactome:REACT_28607
Mitotic Prophase, Rattus norvegicus
Reactome:REACT_32677
Mitotic Prophase, Xenopus tropicalis
Reactome:REACT_765
Mitotic Prophase, Homo sapiens
Reactome:REACT_79474
Mitotic Prophase, Caenorhabditis elegans
Reactome:REACT_80300
Mitotic Prophase, Gallus gallus
Reactome:REACT_83888
Mitotic Prophase, Dictyostelium discoideum
Reactome:REACT_90347
Mitotic Prophase, Canis familiaris
Reactome:REACT_90481
Mitotic Prophase, Schizosaccharomyces pombe
The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.
GOC:mtg_cell_cycle
The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle.
Reactome:REACT_434
biological_process
GO:0000089
Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
mitotic metaphase
The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle.
GOC:mtg_cell_cycle
Reactome:REACT_434
Mitotic Metaphase, Homo sapiens
The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.
biological_process
GO:0000093
Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
mitotic telophase
The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.
GOC:mtg_cell_cycle
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
microtubule cytoskeleton organisation
microtubule dynamics
biological_process
microtubule cytoskeleton organization and biogenesis
GO:0000226
microtubule cytoskeleton organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
GOC:mah
microtubule cytoskeleton organisation
GOC:mah
microtubule dynamics
GOC:dph
GOC:tb
microtubule cytoskeleton organization and biogenesis
GOC:mah
The cell cycle phase in higher eukaryotes which follows mitotic prophase and during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles.
Reactome:REACT_102823
Reactome:REACT_104270
Reactome:REACT_105082
Reactome:REACT_114704
Reactome:REACT_118069
Reactome:REACT_118526
Reactome:REACT_118539
Reactome:REACT_31336
Reactome:REACT_31385
Reactome:REACT_682
Reactome:REACT_79351
Reactome:REACT_83126
Reactome:REACT_98905
Reactome:REACT_99376
biological_process
GO:0000236
Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
mitotic prometaphase
The cell cycle phase in higher eukaryotes which follows mitotic prophase and during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles.
GOC:mtg_cell_cycle
Reactome:REACT_102823
Mitotic Prometaphase, Mus musculus
Reactome:REACT_104270
Mitotic Prometaphase, Bos taurus
Reactome:REACT_105082
Mitotic Prometaphase, Dictyostelium discoideum
Reactome:REACT_114704
Mitotic Prometaphase, Schizosaccharomyces pombe
Reactome:REACT_118069
Mitotic Prometaphase, Gallus gallus
Reactome:REACT_118526
Mitotic Prometaphase, Saccharomyces cerevisiae
Reactome:REACT_118539
Mitotic Prometaphase, Taeniopygia guttata
Reactome:REACT_31336
Mitotic Prometaphase, Danio rerio
Reactome:REACT_31385
Mitotic Prometaphase, Caenorhabditis elegans
Reactome:REACT_682
Mitotic Prometaphase, Homo sapiens
Reactome:REACT_79351
Mitotic Prometaphase, Rattus norvegicus
Reactome:REACT_83126
Mitotic Prometaphase, Drosophila melanogaster
Reactome:REACT_98905
Mitotic Prometaphase, Xenopus tropicalis
Reactome:REACT_99376
Mitotic Prometaphase, Canis familiaris
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
Reactome:REACT_100451
Reactome:REACT_104035
Reactome:REACT_104195
Reactome:REACT_105856
Reactome:REACT_108233
Reactome:REACT_152
Reactome:REACT_28464
Reactome:REACT_28953
Reactome:REACT_33388
Reactome:REACT_53493
Reactome:REACT_79085
Reactome:REACT_84794
Reactome:REACT_85137
Reactome:REACT_85950
Reactome:REACT_90332
Reactome:REACT_90846
Reactome:REACT_96281
Reactome:REACT_97744
Reactome:REACT_98208
biological_process
GO:0000278
mitotic cell cycle
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
GOC:mah
ISBN:0815316194
Reactome:69278
Reactome:REACT_100451
Cell Cycle, Mitotic, Taeniopygia guttata
Reactome:REACT_104035
Cell Cycle, Mitotic, Sus scrofa
Reactome:REACT_104195
Cell Cycle, Mitotic, Canis familiaris
Reactome:REACT_105856
Cell Cycle, Mitotic, Danio rerio
Reactome:REACT_108233
Cell Cycle, Mitotic, Saccharomyces cerevisiae
Reactome:REACT_152
Cell Cycle, Mitotic, Homo sapiens
Reactome:REACT_28464
Cell Cycle, Mitotic, Xenopus tropicalis
Reactome:REACT_28953
Cell Cycle, Mitotic, Bos taurus
Reactome:REACT_33388
Cell Cycle, Mitotic, Rattus norvegicus
Reactome:REACT_53493
Cell Cycle, Mitotic, Plasmodium falciparum
Reactome:REACT_79085
Cell Cycle, Mitotic, Schizosaccharomyces pombe
Reactome:REACT_84794
Cell Cycle, Mitotic, Caenorhabditis elegans
Reactome:REACT_85137
Cell Cycle, Mitotic, Gallus gallus
Reactome:REACT_85950
Cell Cycle, Mitotic, Arabidopsis thaliana
Reactome:REACT_90332
Cell Cycle, Mitotic, Mus musculus
Reactome:REACT_90846
Cell Cycle, Mitotic, Oryza sativa
Reactome:REACT_96281
Cell Cycle, Mitotic, Drosophila melanogaster
Reactome:REACT_97744
Cell Cycle, Mitotic, Dictyostelium discoideum
Reactome:REACT_98208
Cell Cycle, Mitotic, Mycobacterium tuberculosis
A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase.
Wikipedia:M_phase
M-phase
biological_process
GO:0000279
Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
M phase
A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase.
GOC:mtg_cell_cycle
The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.
biological_process
karyokinesis
GO:0000280
nuclear division
The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.
GOC:mah
The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.
DNA breakdown, endonucleolytic
DNA degradation, endonucleolytic
endonucleolytic DNA catabolism
endonucleolytic degradation of DNA
biological_process
GO:0000737
DNA catabolic process, endonucleolytic
The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.
GOC:elh
GOC:mah
The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
GO:0097521
centromere complex
chromosome, centric region
cellular_component
centromere
chromosome, pericentric region
GO:0000775
Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'.
chromosome, centromeric region
The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
GOC:cjm
GOC:elh
GOC:kmv
GOC:pr
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
GO:0005699
Wikipedia:Kinetochore
cellular_component
GO:0000776
Note that the kinetochore overlaps the centromeric DNA, but centromeric DNA is not part of the kinetochore.
kinetochore
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
GOC:elh
The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.
biological_process
GO:0000819
sister chromatid segregation
The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.
GOC:ai
GOC:elh
The developmental process in which the size or shape of a cell is generated and organized.
GO:0007148
GO:0045790
GO:0045791
cellular morphogenesis
biological_process
GO:0000902
cell morphogenesis
The developmental process in which the size or shape of a cell is generated and organized.
GOC:clt
GOC:dph
GOC:go_curators
GOC:tb
The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.
biological_process
GO:0000904
cell morphogenesis involved in differentiation
The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.
GOC:go_curators
The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.
GO:0007104
GO:0016288
GO:0033205
Reactome:REACT_101918
Reactome:REACT_108805
Reactome:REACT_1932
Reactome:REACT_30667
Reactome:REACT_32636
Reactome:REACT_78494
Reactome:REACT_84722
Reactome:REACT_87726
Reactome:REACT_92849
Reactome:REACT_93374
Reactome:REACT_94382
Reactome:REACT_98952
Reactome:REACT_99118
Wikipedia:Cytokinesis
cell cycle cytokinesis
cytokinesis involved in cell cycle
biological_process
GO:0000910
Note that when annotating eukaryotic species, mitotic or meiotic cytokinesis should always be specified for manual annotation and for prokaryotic species use 'FtsZ-dependent cytokinesis ; GO:0043093' or Cdv-dependent cytokinesis ; GO:0061639. Also, note that cytokinesis does not necessarily result in physical separation and detachment of the two daughter cells from each other.
cytokinesis
The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.
GOC:mtg_cell_cycle
Reactome:REACT_101918
Mitotic Telophase /Cytokinesis, Mus musculus
Reactome:REACT_108805
Mitotic Telophase /Cytokinesis, Dictyostelium discoideum
Reactome:REACT_1932
Mitotic Telophase /Cytokinesis, Homo sapiens
Reactome:REACT_30667
Mitotic Telophase /Cytokinesis, Schizosaccharomyces pombe
Reactome:REACT_32636
Mitotic Telophase /Cytokinesis, Bos taurus
Reactome:REACT_78494
Mitotic Telophase /Cytokinesis, Danio rerio
Reactome:REACT_84722
Mitotic Telophase /Cytokinesis, Gallus gallus
Reactome:REACT_87726
Mitotic Telophase /Cytokinesis, Xenopus tropicalis
Reactome:REACT_92849
Mitotic Telophase /Cytokinesis, Taeniopygia guttata
Reactome:REACT_93374
Mitotic Telophase /Cytokinesis, Canis familiaris
Reactome:REACT_94382
Mitotic Telophase /Cytokinesis, Drosophila melanogaster
Reactome:REACT_98952
Mitotic Telophase /Cytokinesis, Rattus norvegicus
Reactome:REACT_99118
Mitotic Telophase /Cytokinesis, Caenorhabditis elegans
cytokinesis involved in cell cycle
GOC:dph
GOC:tb
Interacting selectively and non-covalently with a DNA region that regulates a DNA-based process. Such processes include transcription, DNA replication, and DNA repair.
kchris
2010-08-10T10:56:24Z
molecular_function
GO:0000975
regulatory region DNA binding
Interacting selectively and non-covalently with a DNA region that regulates a DNA-based process. Such processes include transcription, DNA replication, and DNA repair.
GOC:txnOH
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
kchris
2010-08-10T11:00:02Z
molecular_function
GO:0000976
The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
transcription regulatory region sequence-specific DNA binding
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
GOC:txnOH
Interacting selectively and non-covalently with a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair.
kchris
2010-10-21T04:08:56Z
molecular_function
GO:0001067
regulatory region nucleic acid binding
Interacting selectively and non-covalently with a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair.
GOC:txnOH
Interacting selectively and non-covalently with a DNA or RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
kchris
2010-10-21T04:37:54Z
transcription factor activity
molecular_function
GO:0001071
Note that this term is in the subset of terms that should not be used for direct gene product annotation. This term does not provide specificity with respect to the type of nucleic acid binding, e.g. RNA or DNA. Please use a child term that provides that specificity or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
nucleic acid binding transcription factor activity
Interacting selectively and non-covalently with a DNA or RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
GOC:txnOH
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
stress fibre
cellular_component
actin cable
GO:0001725
stress fiber
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
PMID:16651381
actin cable
GOC:mah
Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.
biological_process
necrosis
GO:0001906
cell killing
Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.
GOC:add
The directed killing of a target cell by a leukocyte.
immune cell mediated cell death
immune cell mediated cell killing
immune cell mediated cytotoxicity
leucocyte mediated cytotoxicity
biological_process
GO:0001909
This term was improved by GO_REF:0000022. It was moved. Note that this term and its children describe contact-dependent killing of target cells by lymphocytes and myeloid cells of the immune system.
leukocyte mediated cytotoxicity
The directed killing of a target cell by a leukocyte.
GOC:add
GOC:mtg_15nov05
GO_REF:0000022
ISBN:0781735149
PMID:11911826
The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
T cell mediated apoptosis
T cell mediated cell death
T cell mediated cell killing
T lymphocyte mediated cytotoxicity
T-cell mediated apoptosis
T-cell mediated cell death
T-cell mediated cell killing
T-cell mediated cytotoxicity
T-lymphocyte mediated cytotoxicity
biological_process
T cell mediated cytolysis
GO:0001913
Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not.
T cell mediated cytotoxicity
The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
GOC:add
GOC:pr
ISBN:0781735149
PMID:11911826
An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
Wikipedia:Podosome
cellular_component
GO:0002102
Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation.
podosome
An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
PMID:12837608
PMID:15890982
An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).
Wikipedia:Adaptive_immune_system
acquired immune response
biological_process
GO:0002250
This term was added by GO_REF:0000022.
adaptive immune response
An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).
GOC:add
GOC:mtg_15nov05
GO_REF:0000022
ISBN:0781735149
acquired immune response
ISBN:068340007X
Any process of the immune system that can potentially contribute to an immune response.
biological_process
GO:0002252
This term was added by GO_REF:0000022.
immune effector process
Any process of the immune system that can potentially contribute to an immune response.
GOC:add
GOC:mtg_15nov05
GO_REF:0000022
ISBN:0781735149
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell.
biological_process
GO:0002347
response to tumor cell
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell.
GOC:add
ISBN:0781735149
PMID:16730260
Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
Wikipedia:Immune_system
biological_process
GO:0002376
Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). This term was added by GO_REF:0000022.
immune system process
Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
GOC:add
GOC:mtg_15nov05
GO_REF:0000022
An immune system process that functions in the response of an organism to a tumor cell.
biological_process
GO:0002418
immune response to tumor cell
An immune system process that functions in the response of an organism to a tumor cell.
GOC:add
ISBN:0781735149
PMID:16730260
The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
T lymphocyte mediated cytotoxicity directed against tumor cell target
T-cell mediated cytotoxicity directed against tumor cell target
T-lymphocyte mediated cytotoxicity directed against tumor cell target
biological_process
GO:0002419
Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
T cell mediated cytotoxicity directed against tumor cell target
The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
GOC:add
ISBN:0781735149
PMID:16730260
An immune response mediated by a T cell triggered in response to the presence of a tumor cell.
biological_process
GO:0002424
Note that this term includes tolerogenic responses to tumor cells mediated by responding T cells.
T cell mediated immune response to tumor cell
An immune response mediated by a T cell triggered in response to the presence of a tumor cell.
GOC:add
ISBN:0781735149
PMID:16730260
Any process involved in the carrying out of an immune response by a leukocyte.
GO:0019723
GO:0042087
immune cell effector process
immune cell mediated immunity
leucocyte immune effector process
leucocyte mediated immunity
leukocyte immune effector process
biological_process
cell-mediated immune response
cellular immune response
GO:0002443
This term was added by GO_REF:0000022.
leukocyte mediated immunity
Any process involved in the carrying out of an immune response by a leukocyte.
GOC:add
GOC:mtg_15nov05
GO_REF:0000022
ISBN:0781735149
Any process involved in the carrying out of an immune response by a lymphocyte.
cell-mediated immunity
cellular immune response
biological_process
GO:0002449
This term was added by GO_REF:0000022.
lymphocyte mediated immunity
Any process involved in the carrying out of an immune response by a lymphocyte.
GOC:add
GOC:mtg_15nov05
GO_REF:0000022
ISBN:0781735149
Any process involved in the carrying out of an immune response by a T cell.
cell-mediated immunity
cellular immune response
T lymphocyte mediated immunity
T-cell mediated immunity
T-lymphocyte mediated immunity
biological_process
GO:0002456
This term was added by GO_REF:0000022.
T cell mediated immunity
Any process involved in the carrying out of an immune response by a T cell.
GOC:add
GOC:mtg_15nov05
GO_REF:0000022
ISBN:0781735149
An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus.
biological_process
GO:0002460
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus.
GOC:add
GOC:mtg_sensu
ISBN:0781735149
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:0005554
molecular function
molecular_function
GO:0003674
Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. Note that when this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GOC:go_curators
Interacting selectively and non-covalently with any nucleic acid.
molecular_function
GO:0003676
nucleic acid binding
Interacting selectively and non-covalently with any nucleic acid.
GOC:jl
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
plasmid binding
molecular_function
microtubule/chromatin interaction
GO:0003677
DNA binding
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GOC:dph
GOC:jl
GOC:tb
GOC:vw
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
GO:0000130
transcription factor activity
molecular_function
GO:0003700
sequence-specific DNA binding transcription factor activity
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
GOC:curators
GOC:txnOH
Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence.
EC:2.7.7.-
Reactome:REACT_104705
Reactome:REACT_106476
Reactome:REACT_108407
Reactome:REACT_109443
Reactome:REACT_113385
Reactome:REACT_114466
Reactome:REACT_115824
Reactome:REACT_116122
Reactome:REACT_28249
Reactome:REACT_30494
Reactome:REACT_30995
Reactome:REACT_31549
Reactome:REACT_33436
Reactome:REACT_77280
Reactome:REACT_7985
Reactome:REACT_8019
Reactome:REACT_80834
Reactome:REACT_81691
Reactome:REACT_83982
Reactome:REACT_85286
Reactome:REACT_86666
Reactome:REACT_90823
Reactome:REACT_93232
Reactome:REACT_94534
Reactome:REACT_94768
Reactome:REACT_95176
Reactome:REACT_96912
Reactome:REACT_97770
molecular_function
GO:0003720
telomerase activity
Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence.
GOC:krc
Reactome:REACT_104705
Elongation of Extended Telomeric Chromosome End, Saccharomyces cerevisiae
Reactome:REACT_106476
Elongation Of The Telomeric Chromosome End, Bos taurus
Reactome:REACT_108407
Elongation of Extended Telomeric Chromosome End, Oryza sativa
Reactome:REACT_109443
Elongation Of The Telomeric Chromosome End, Danio rerio
Reactome:REACT_113385
Elongation Of The Telomeric Chromosome End, Xenopus tropicalis
Reactome:REACT_114466
Elongation of Extended Telomeric Chromosome End, Xenopus tropicalis
Reactome:REACT_115824
Elongation and translocation of the extended telomeric chromosome end, Gallus gallus
Reactome:REACT_116122
Elongation and translocation of the telomeric chromosome end, Gallus gallus
Reactome:REACT_28249
Elongation of Extended Telomeric Chromosome End, Gallus gallus
Reactome:REACT_30494
Elongation Of The Telomeric Chromosome End, Sus scrofa
Reactome:REACT_30995
Elongation Of The Telomeric Chromosome End, Canis familiaris
Reactome:REACT_31549
Elongation Of The Telomeric Chromosome End, Saccharomyces cerevisiae
Reactome:REACT_33436
Elongation of Extended Telomeric Chromosome End, Danio rerio
Reactome:REACT_77280
Elongation of Extended Telomeric Chromosome End, Arabidopsis thaliana
Reactome:REACT_7985
Elongation of Extended Telomeric Chromosome End, Homo sapiens
Reactome:REACT_8019
Elongation Of The Telomeric Chromosome End, Homo sapiens
Reactome:REACT_80834
Elongation Of The Telomeric Chromosome End, Mus musculus
Reactome:REACT_81691
Elongation of Extended Telomeric Chromosome End, Canis familiaris
Reactome:REACT_83982
Elongation Of The Telomeric Chromosome End, Oryza sativa
Reactome:REACT_85286
Elongation of Extended Telomeric Chromosome End, Bos taurus
Reactome:REACT_86666
Elongation of Extended Telomeric Chromosome End, Sus scrofa
Reactome:REACT_90823
Elongation of Extended Telomeric Chromosome End, Mus musculus
Reactome:REACT_93232
Elongation Of The Telomeric Chromosome End, Schizosaccharomyces pombe
Reactome:REACT_94534
Elongation Of The Telomeric Chromosome End, Taeniopygia guttata
Reactome:REACT_94768
Elongation of Extended Telomeric Chromosome End, Schizosaccharomyces pombe
Reactome:REACT_95176
Elongation Of The Telomeric Chromosome End, Gallus gallus
Reactome:REACT_96912
Elongation of Extended Telomeric Chromosome End, Taeniopygia guttata
Reactome:REACT_97770
Elongation Of The Telomeric Chromosome End, Arabidopsis thaliana
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
Wikipedia:Enzyme
enzyme activity
molecular_function
GO:0003824
catalytic activity
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
ISBN:0198506732
enzyme activity
GOC:dph
GOC:tb
Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time.
EC:2.7.7.49
MetaCyc:RNA-DIRECTED-DNA-POLYMERASE-RXN
Reactome:REACT_9039
Reactome:REACT_9049
DNA nucleotidyltransferase (RNA-directed) activity
RNA revertase activity
RNA-dependent DNA polymerase activity
RNA-dependent deoxyribonucleate nucleotidyltransferase activity
RNA-instructed DNA polymerase activity
deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity
reverse transcriptase activity
RNA-directed DNA polymerase, group II intron encoded
RNA-directed DNA polymerase, transposon encoded
molecular_function
RT
revertase activity
GO:0003964
RNA-directed DNA polymerase activity
Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time.
EC:2.7.7.49
Reactome:REACT_9039
Synthesis of minus strand strong stop DNA (-sssDNA), Homo sapiens
Reactome:REACT_9049
Minus strand DNA synthesis resumes, Homo sapiens
DNA nucleotidyltransferase (RNA-directed) activity
EC:2.7.7.49
RNA revertase activity
EC:2.7.7.49
RNA-dependent DNA polymerase activity
EC:2.7.7.49
RNA-dependent deoxyribonucleate nucleotidyltransferase activity
EC:2.7.7.49
RNA-instructed DNA polymerase activity
EC:2.7.7.49
deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity
EC:2.7.7.49
reverse transcriptase activity
EC:2.7.7.49
RT
EC:2.7.7.49
revertase activity
EC:2.7.7.49
Catalysis of the hydrolysis of ester linkages within nucleic acids.
EC:3.1.-.-
molecular_function
GO:0004518
Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis.
nuclease activity
Catalysis of the hydrolysis of ester linkages within nucleic acids.
ISBN:0198547684
Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
Reactome:REACT_100654
Reactome:REACT_101397
Reactome:REACT_103600
Reactome:REACT_106502
Reactome:REACT_108614
Reactome:REACT_110731
Reactome:REACT_112366
Reactome:REACT_1124
Reactome:REACT_112509
Reactome:REACT_112615
Reactome:REACT_112782
Reactome:REACT_113127
Reactome:REACT_113480
Reactome:REACT_113819
Reactome:REACT_114931
Reactome:REACT_115221
Reactome:REACT_115226
Reactome:REACT_115382
Reactome:REACT_115937
Reactome:REACT_116011
Reactome:REACT_1914
Reactome:REACT_34610
Reactome:REACT_6746
Reactome:REACT_6774
Reactome:REACT_77706
Reactome:REACT_78624
Reactome:REACT_79198
Reactome:REACT_80387
Reactome:REACT_80628
Reactome:REACT_80681
Reactome:REACT_80797
Reactome:REACT_81714
Reactome:REACT_87541
Reactome:REACT_89800
Reactome:REACT_90034
Reactome:REACT_90935
Reactome:REACT_92894
molecular_function
GO:0004519
endonuclease activity
Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
GOC:mah
ISBN:0198547684
Reactome:REACT_100654
3'- incision of DNA by XPG in GG-NER, Arabidopsis thaliana
Reactome:REACT_101397
3'- incision of DNA by XPG in GG-NER, Danio rerio
Reactome:REACT_103600
3'- incision of DNA by XPG in GG-NER, Gallus gallus
Reactome:REACT_106502
3'- incision of DNA by XPG in GG-NER, Rattus norvegicus
Reactome:REACT_108614
3'- incision of DNA by XPG in GG-NER, Taeniopygia guttata
Reactome:REACT_110731
3'- incision of DNA by XPG in GG-NER, Xenopus tropicalis
Reactome:REACT_112366
Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Danio rerio
Reactome:REACT_1124
3'- incision of DNA by XPG in GG-NER, Homo sapiens
Reactome:REACT_112509
Cleavage of mRNA at the 3'-end, Arabidopsis thaliana
Reactome:REACT_112615
Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Rattus norvegicus
Reactome:REACT_112782
Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Xenopus tropicalis
Reactome:REACT_113127
Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Taeniopygia guttata
Reactome:REACT_113480
Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Gallus gallus
Reactome:REACT_113819
Cleavage of mRNA at the 3'-end, Drosophila melanogaster
Reactome:REACT_114931
Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Canis familiaris
Reactome:REACT_115221
Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Mus musculus
Reactome:REACT_115226
Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Bos taurus
Reactome:REACT_115382
Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Sus scrofa
Reactome:REACT_115937
Displacement of DNA glycosylase and endonucleolytic cleavage by DNA-lyase, Gallus gallus
Reactome:REACT_116011
Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Gallus gallus
Reactome:REACT_1914
Cleavage of mRNA at the 3'-end, Homo sapiens
Reactome:REACT_34610
Cleavage of mRNA at the 3'-end, Bos taurus
Reactome:REACT_6746
Removal of 3'-phosphate moiety from DSB ends, Homo sapiens
Reactome:REACT_6774
Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Homo sapiens
Reactome:REACT_77706
Cleavage of mRNA at the 3'-end, Taeniopygia guttata
Reactome:REACT_78624
3'- incision of DNA by XPG in GG-NER, Canis familiaris
Reactome:REACT_79198
Cleavage of mRNA at the 3'-end, Canis familiaris
Reactome:REACT_80387
3'- incision of DNA by XPG in GG-NER, Caenorhabditis elegans
Reactome:REACT_80628
3'- incision of DNA by XPG in GG-NER, Saccharomyces cerevisiae
Reactome:REACT_80681
3'- incision of DNA by XPG in GG-NER, Bos taurus
Reactome:REACT_80797
Cleavage of mRNA at the 3'-end, Mus musculus
Reactome:REACT_81714
3'- incision of DNA by XPG in GG-NER, Oryza sativa
Reactome:REACT_87541
Cleavage of mRNA at the 3'-end, Xenopus tropicalis
Reactome:REACT_89800
3'- incision of DNA by XPG in GG-NER, Schizosaccharomyces pombe
Reactome:REACT_90034
3'- incision of DNA by XPG in GG-NER, Mus musculus
Reactome:REACT_90935
3'- incision of DNA by XPG in GG-NER, Sus scrofa
Reactome:REACT_92894
3'- incision of DNA by XPG in GG-NER, Drosophila melanogaster
Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.
Reactome:REACT_101184
Reactome:REACT_101250
Reactome:REACT_101987
Reactome:REACT_103441
Reactome:REACT_103771
Reactome:REACT_104010
Reactome:REACT_104673
Reactome:REACT_104703
Reactome:REACT_104968
Reactome:REACT_106756
Reactome:REACT_109040
Reactome:REACT_109537
Reactome:REACT_109692
Reactome:REACT_110386
Reactome:REACT_112122
Reactome:REACT_112152
Reactome:REACT_115154
Reactome:REACT_115463
Reactome:REACT_115479
Reactome:REACT_1274
Reactome:REACT_1311
Reactome:REACT_1964
Reactome:REACT_27164
Reactome:REACT_27209
Reactome:REACT_28610
Reactome:REACT_28960
Reactome:REACT_30718
Reactome:REACT_31162
Reactome:REACT_31548
Reactome:REACT_31660
Reactome:REACT_31823
Reactome:REACT_32833
Reactome:REACT_33043
Reactome:REACT_78421
Reactome:REACT_79265
Reactome:REACT_80173
Reactome:REACT_80298
Reactome:REACT_80967
Reactome:REACT_811
Reactome:REACT_81197
Reactome:REACT_82925
Reactome:REACT_83838
Reactome:REACT_85019
Reactome:REACT_88339
Reactome:REACT_90087
Reactome:REACT_92741
Reactome:REACT_94592
Reactome:REACT_94820
Reactome:REACT_95903
Reactome:REACT_97114
Reactome:REACT_98405
Reactome:REACT_98417
Reactome:REACT_99783
molecular_function
DNA nicking activity
endonuclease G activity
GO:0004520
endodeoxyribonuclease activity
Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.
GOC:mah
ISBN:0198547684
Reactome:REACT_101184
5'-incision of DNA by ERCC1-XPF in GG-NER, Danio rerio
Reactome:REACT_101250
5' incision leading to excision of DNA fragment with lesion in TC-NER, Caenorhabditis elegans
Reactome:REACT_101987
APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Dictyostelium discoideum
Reactome:REACT_103441
APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Rattus norvegicus
Reactome:REACT_103771
3' incision of the lesioned strand of DNA in TC-NER, Xenopus tropicalis
Reactome:REACT_104010
APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Danio rerio
Reactome:REACT_104673
5' incision leading to excision of DNA fragment with lesion in TC-NER, Schizosaccharomyces pombe
Reactome:REACT_104703
APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Taeniopygia guttata
Reactome:REACT_104968
APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Sus scrofa
Reactome:REACT_106756
3' incision of the lesioned strand of DNA in TC-NER, Drosophila melanogaster
Reactome:REACT_109040
3' incision of the lesioned strand of DNA in TC-NER, Canis familiaris
Reactome:REACT_109537
APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Xenopus tropicalis
Reactome:REACT_109692
3' incision of the lesioned strand of DNA in TC-NER, Sus scrofa
Reactome:REACT_110386
3' incision of the lesioned strand of DNA in TC-NER, Danio rerio
Reactome:REACT_112122
5'-incision of DNA by ERCC1-XPF in GG-NER, Xenopus tropicalis
Reactome:REACT_112152
3' incision of the lesioned strand of DNA in TC-NER, Taeniopygia guttata
Reactome:REACT_115154
5' incision leading to excision of DNA fragment with lesion in TC-NER, Gallus gallus
Reactome:REACT_115463
5' incision leading to excision of DNA fragment with lesion in TC-NER, Taeniopygia guttata
Reactome:REACT_115479
3' incision of the lesioned strand of DNA in TC-NER, Gallus gallus
Reactome:REACT_1274
3' incision of the lesioned strand of DNA in TC-NER, Homo sapiens
Reactome:REACT_1311
5'-incision of DNA by ERCC1-XPF in GG-NER, Homo sapiens
Reactome:REACT_1964
APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Homo sapiens
Reactome:REACT_27164
Removal of SPO11 and Resection of 5' Ends of DNA (yeast), Saccharomyces cerevisiae
Reactome:REACT_27209
Removal of SPO11 and Resection of 5' Ends of DNA, Homo sapiens
Reactome:REACT_28610
5' incision leading to excision of DNA fragment with lesion in TC-NER, Bos taurus
Reactome:REACT_28960
3' incision of the lesioned strand of DNA in TC-NER, Rattus norvegicus
Reactome:REACT_30718
3' incision of the lesioned strand of DNA in TC-NER, Dictyostelium discoideum
Reactome:REACT_31162
5' incision leading to excision of DNA fragment with lesion in TC-NER, Arabidopsis thaliana
Reactome:REACT_31548
APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Caenorhabditis elegans
Reactome:REACT_31660
3' incision of the lesioned strand of DNA in TC-NER, Schizosaccharomyces pombe
Reactome:REACT_31823
5' incision leading to excision of DNA fragment with lesion in TC-NER, Oryza sativa
Reactome:REACT_32833
3' incision of the lesioned strand of DNA in TC-NER, Saccharomyces cerevisiae
Reactome:REACT_33043
3' incision of the lesioned strand of DNA in TC-NER, Bos taurus
Reactome:REACT_78421
5' incision leading to excision of DNA fragment with lesion in TC-NER, Sus scrofa
Reactome:REACT_79265
5' incision leading to excision of DNA fragment with lesion in TC-NER, Dictyostelium discoideum
Reactome:REACT_80173
APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Mus musculus
Reactome:REACT_80298
3' incision of the lesioned strand of DNA in TC-NER, Caenorhabditis elegans
Reactome:REACT_80967
3' incision of the lesioned strand of DNA in TC-NER, Oryza sativa
Reactome:REACT_811
5' incision leading to excision of DNA fragment with lesion in TC-NER, Homo sapiens
Reactome:REACT_81197
5' incision leading to excision of DNA fragment with lesion in TC-NER, Mus musculus
Reactome:REACT_82925
5' incision leading to excision of DNA fragment with lesion in TC-NER, Canis familiaris
Reactome:REACT_83838
5'-incision of DNA by ERCC1-XPF in GG-NER, Rattus norvegicus
Reactome:REACT_85019
APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Drosophila melanogaster
Reactome:REACT_88339
5' incision leading to excision of DNA fragment with lesion in TC-NER, Rattus norvegicus
Reactome:REACT_90087
5' incision leading to excision of DNA fragment with lesion in TC-NER, Danio rerio
Reactome:REACT_92741
3' incision of the lesioned strand of DNA in TC-NER, Arabidopsis thaliana
Reactome:REACT_94592
5' incision leading to excision of DNA fragment with lesion in TC-NER, Drosophila melanogaster
Reactome:REACT_94820
APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Canis familiaris
Reactome:REACT_95903
5'-incision of DNA by ERCC1-XPF in GG-NER, Mus musculus
Reactome:REACT_97114
5' incision leading to excision of DNA fragment with lesion in TC-NER, Xenopus tropicalis
Reactome:REACT_98405
5' incision leading to excision of DNA fragment with lesion in TC-NER, Saccharomyces cerevisiae
Reactome:REACT_98417
APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Bos taurus
Reactome:REACT_99783
3' incision of the lesioned strand of DNA in TC-NER, Mus musculus
DNA nicking activity
GOC:mah
Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid.
GO:0004537
Reactome:REACT_100642
Reactome:REACT_101208
Reactome:REACT_110575
Reactome:REACT_13702
Reactome:REACT_29722
Reactome:REACT_31853
Reactome:REACT_90424
Reactome:REACT_95359
Reactome:REACT_98682
caspase-activated deoxyribonuclease activity
molecular_function
GO:0004536
deoxyribonuclease activity
Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid.
GOC:mah
ISBN:0198547684
Reactome:REACT_100642
Cleavage of DNA by DFF40, Xenopus tropicalis
Reactome:REACT_101208
Cleavage of DNA by DFF40, Bos taurus
Reactome:REACT_110575
Cleavage of DNA by DFF40, Sus scrofa
Reactome:REACT_13702
Cleavage of DNA by DFF40, Homo sapiens
Reactome:REACT_29722
Cleavage of DNA by DFF40, Danio rerio
Reactome:REACT_31853
Cleavage of DNA by DFF40, Taeniopygia guttata
Reactome:REACT_90424
Cleavage of DNA by DFF40, Gallus gallus
Reactome:REACT_95359
Cleavage of DNA by DFF40, Rattus norvegicus
Reactome:REACT_98682
Cleavage of DNA by DFF40, Canis familiaris
The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
Wikipedia:Binding_(molecular)
ligand
molecular_function
GO:0005488
Note that this term is in the subset of terms that should not be used for direct, manual gene product annotation. Please choose a more specific child term, or request a new one if no suitable term is available. For ligands that bind to signal transducing receptors, consider the molecular function term 'receptor binding ; GO:0005102' and its children.
binding
The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
GOC:ceb
GOC:mah
ISBN:0198506732
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
GO:0008372
NIF_Subcellular:sao-1337158144
NIF_Subcellular:sao1337158144
cell or subcellular entity
cellular component
cellular_component
subcellular entity
GO:0005575
Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. Note that when this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
GOC:go_curators
NIF_Subcellular:sao-1337158144
subcellular entity
NIF_Subcellular:nlx_subcell_100315
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
Wikipedia:Intracellular
internal to cell
protoplasm
cellular_component
nucleocytoplasm
protoplast
GO:0005622
intracellular
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
ISBN:0198506732
nucleocytoplasm
GOC:mah
protoplast
GOC:mah
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
cell and encapsulating structures
NIF_Subcellular:sao1813327414
Wikipedia:Cell_(biology)
cellular_component
GO:0005623
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
GOC:go_curators
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
NIF_Subcellular:sao1702920020
Wikipedia:Cell_nucleus
cell nucleus
cellular_component
GO:0005634
nucleus
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
GOC:go_curators
That part of the nuclear content other than the chromosomes or the nucleolus.
NIF_Subcellular:sao661522542
Wikipedia:Nucleoplasm
cellular_component
GO:0005654
nucleoplasm
That part of the nuclear content other than the chromosomes or the nucleolus.
GOC:ma
ISBN:0124325653
A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
Wikipedia:Chromosome
interphase chromosome
prophase chromosome
cellular_component
chromatid
GO:0005694
Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore.
chromosome
A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
ISBN:0198547684
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
NIF_Subcellular:sao1820400233
Wikipedia:Nucleolus
cellular_component
GO:0005730
nucleolus
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
ISBN:0198506732
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
Wikipedia:Cytoplasm
cellular_component
GO:0005737
cytoplasm
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
ISBN:0198547684
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
NIF_Subcellular:sao1860313010
Wikipedia:Mitochondrion
mitochondria
cellular_component
GO:0005739
Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.)
mitochondrion
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
GOC:giardia
ISBN:0198506732
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
Wikipedia:Vacuole
cellular_component
vacuolar carboxypeptidase Y
GO:0005773
vacuole
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
GOC:mtg_sensu
ISBN:0198506732
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
NIF_Subcellular:sao1036339110
Wikipedia:Endoplasmic_reticulum
ER
cellular_component
GO:0005783
endoplasmic reticulum
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
ISBN:0198506732
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
Golgi
NIF_Subcellular:sao451912436
Wikipedia:Golgi_apparatus
Golgi complex
Golgi ribbon
cellular_component
GO:0005794
Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.
Golgi apparatus
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
ISBN:0198506732
The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
Wikipedia:Spindle_apparatus
cellular_component
GO:0005819
spindle
The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
ISBN:0198547684
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
NIF_Subcellular:sao101633890
Wikipedia:Cytosol
cellular_component
GO:0005829
cytosol
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GOC:hgd
GOC:jl
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
Wikipedia:Cytoskeleton
cellular_component
GO:0005856
cytoskeleton
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
GOC:mah
ISBN:0198547684
PMID:16959967
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
NIF_Subcellular:sao1846835077
Wikipedia:Microtubule
microtubuli
microtubulus
neurotubule
cellular_component
GO:0005874
microtubule
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
ISBN:0879693568
neurotubule
NIF_Subcellular:sao248349196
Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.
cellular_component
GO:0005876
spindle microtubule
Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.
ISBN:0815316194
Any microtubule in the cytoplasm of a cell.
non-spindle-associated astral microtubule
cellular_component
GO:0005881
cytoplasmic microtubule
Any microtubule in the cytoplasm of a cell.
GOC:mah
A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.
FMA:63850
NIF_Subcellular:sao1588493326
Wikipedia:Actin
microfilament
cellular_component
GO:0005884
actin filament
A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.
GOC:mah
ISBN:0198506732
PMID:10666339
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0005904
juxtamembrane
NIF_Subcellular:sao1663586795
Wikipedia:Cell_membrane
cell membrane
cellular membrane
cytoplasmic membrane
plasmalemma
bacterial inner membrane
inner endospore membrane
plasma membrane lipid bilayer
cellular_component
GO:0005886
plasma membrane
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
ISBN:0716731363
cellular membrane
NIF_Subcellular:sao6433132645
plasma membrane lipid bilayer
GOC:mah
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
Wikipedia:Adherens_junction
cellular_component
GO:0005912
adherens junction
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
GOC:mah
ISBN:0198506732
http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html
An adherens junction which connects a cell to the extracellular matrix.
cellular_component
hemi-adherens junction
GO:0005924
cell-substrate adherens junction
An adherens junction which connects a cell to the extracellular matrix.
GOC:hb
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
GO:0008357
Wikipedia:Focal_adhesion
focal contact
cellular_component
adhesion plaque
hemi-adherens junction
GO:0005925
focal adhesion
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
ISBN:0124325653
ISBN:0815316208
adhesion plaque
PMID:3332661
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
FMA:67181
NIF_Subcellular:sao787716553
Wikipedia:Cilium
eukaryotic flagellum
microtubule-based flagellum
cellular_component
flagellum
GO:0005929
Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly.
cilium
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
GOC:cilia
GOC:kmv
GOC:vw
ISBN:0198547684
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
Wikipedia:Cell_cortex
cellular_component
cell periphery
peripheral cytoplasm
GO:0005938
cell cortex
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
GOC:mah
ISBN:0815316194
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
GO:0055134
cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
biological_process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GO:0006139
nucleobase-containing compound metabolic process
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
GOC:ai
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GOC:dph
GOC:tb
Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
GO:0055132
DNA metabolism
cellular DNA metabolism
biological_process
GO:0006259
DNA metabolic process
Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
ISBN:0198506732
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
GO:0055133
Reactome:REACT_100559
Reactome:REACT_101280
Reactome:REACT_101497
Reactome:REACT_102679
Reactome:REACT_103614
Reactome:REACT_104547
Reactome:REACT_105292
Reactome:REACT_105467
Reactome:REACT_105835
Reactome:REACT_106018
Reactome:REACT_106104
Reactome:REACT_106382
Reactome:REACT_106434
Reactome:REACT_106732
Reactome:REACT_107075
Reactome:REACT_107423
Reactome:REACT_108461
Reactome:REACT_108634
Reactome:REACT_108739
Reactome:REACT_108768
Reactome:REACT_108929
Reactome:REACT_109137
Reactome:REACT_112472
Reactome:REACT_113703
Reactome:REACT_29423
Reactome:REACT_29444
Reactome:REACT_29691
Reactome:REACT_29764
Reactome:REACT_30149
Reactome:REACT_31024
Reactome:REACT_31919
Reactome:REACT_32546
Reactome:REACT_32932
Reactome:REACT_33572
Reactome:REACT_33874
Reactome:REACT_50018
Reactome:REACT_53588
Reactome:REACT_6729
Reactome:REACT_6738
Reactome:REACT_6750
Reactome:REACT_6769
Reactome:REACT_6798
Reactome:REACT_6869
Reactome:REACT_6936
Reactome:REACT_6939
Reactome:REACT_77532
Reactome:REACT_79188
Reactome:REACT_79450
Reactome:REACT_80432
Reactome:REACT_80571
Reactome:REACT_80896
Reactome:REACT_80988
Reactome:REACT_81803
Reactome:REACT_83095
Reactome:REACT_84829
Reactome:REACT_85561
Reactome:REACT_86410
Reactome:REACT_86739
Reactome:REACT_87233
Reactome:REACT_87449
Reactome:REACT_87590
Reactome:REACT_88085
Reactome:REACT_88384
Reactome:REACT_88529
Reactome:REACT_89355
Reactome:REACT_89439
Reactome:REACT_89725
Reactome:REACT_90512
Reactome:REACT_90809
Reactome:REACT_90838
Reactome:REACT_91184
Reactome:REACT_91302
Reactome:REACT_92527
Reactome:REACT_92644
Reactome:REACT_92706
Reactome:REACT_94983
Reactome:REACT_95253
Reactome:REACT_95329
Reactome:REACT_96115
Reactome:REACT_96804
Reactome:REACT_96998
Reactome:REACT_97204
Reactome:REACT_97726
Reactome:REACT_99948
Wikipedia:DNA_replication
biological_process
GO:0006260
See also the biological process terms 'DNA-dependent DNA replication ; GO:0006261' and 'RNA-dependent DNA replication ; GO:0006278'.
DNA replication
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
GOC:mah
Reactome:REACT_100559
Activation of ATR in response to replication stress, Mus musculus
Reactome:REACT_101280
Activation of claspin, Xenopus tropicalis
Reactome:REACT_101497
Activation of claspin, Bos taurus
Reactome:REACT_102679
Activation of ATR in response to replication stress, Gallus gallus
Reactome:REACT_103614
Stalling of DNA replication fork and RPA binding, Taeniopygia guttata
Reactome:REACT_104547
Recruitment and activation of Chk1, Gallus gallus
Reactome:REACT_105292
Activation of ATR in response to replication stress, Xenopus tropicalis
Reactome:REACT_105467
Loading of claspin onto DNA during replication origin firing, Danio rerio
Reactome:REACT_105835
Stalling of DNA replication fork and RPA binding, Gallus gallus
Reactome:REACT_106018
Recruitment of Rad17-RFC complex to DNA, Gallus gallus
Reactome:REACT_106104
Binding of ATR-ATRIP to the RPA-ssDNA complex, Bos taurus
Reactome:REACT_106382
Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Drosophila melanogaster
Reactome:REACT_106434
Activation of claspin, Canis familiaris
Reactome:REACT_106732
Recruitment and activation of Chk1, Canis familiaris
Reactome:REACT_107075
Activation of ATR in response to replication stress, Danio rerio
Reactome:REACT_107423
Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Caenorhabditis elegans
Reactome:REACT_108461
Recruitment and activation of Chk1, Bos taurus
Reactome:REACT_108634
Loading of claspin onto DNA during replication origin firing, Mus musculus
Reactome:REACT_108739
Binding of ATR-ATRIP to the RPA-ssDNA complex, Xenopus tropicalis
Reactome:REACT_108768
Activation of ATR in response to replication stress, Bos taurus
Reactome:REACT_108929
Activation of ATR in response to replication stress, Drosophila melanogaster
Reactome:REACT_109137
Stalling of DNA replication fork and RPA binding, Rattus norvegicus
Reactome:REACT_112472
Activation of ATR in response to replication stress, Saccharomyces cerevisiae
Reactome:REACT_113703
Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Gallus gallus
Reactome:REACT_29423
Activation of ATR in response to replication stress, Schizosaccharomyces pombe
Reactome:REACT_29444
Binding of ATR-ATRIP to the RPA-ssDNA complex, Taeniopygia guttata
Reactome:REACT_29691
Activation of ATR in response to replication stress, Rattus norvegicus
Reactome:REACT_29764
Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Taeniopygia guttata
Reactome:REACT_30149
Activation of claspin, Rattus norvegicus
Reactome:REACT_31024
Recruitment of Rad17-RFC complex to DNA, Xenopus tropicalis
Reactome:REACT_31919
Loading of claspin onto DNA during replication origin firing, Rattus norvegicus
Reactome:REACT_32546
Recruitment of Rad17-RFC complex to DNA, Mus musculus
Reactome:REACT_32932
Recruitment and activation of Chk1, Taeniopygia guttata
Reactome:REACT_33572
Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Dictyostelium discoideum
Reactome:REACT_33874
Recruitment and activation of Chk1, Xenopus tropicalis
Reactome:REACT_50018
Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Rattus norvegicus
Reactome:REACT_53588
Loading of claspin onto DNA during replication origin firing, Canis familiaris
Reactome:REACT_6729
Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Homo sapiens
Reactome:REACT_6738
Loading of claspin onto DNA during replication origin firing, Homo sapiens
Reactome:REACT_6750
Activation of claspin, Homo sapiens
Reactome:REACT_6769
Activation of ATR in response to replication stress, Homo sapiens
Reactome:REACT_6798
Recruitment of Rad17-RFC complex to DNA, Homo sapiens
Reactome:REACT_6869
Recruitment and activation of Chk1, Homo sapiens
Reactome:REACT_6936
Stalling of DNA replication fork and RPA binding, Homo sapiens
Reactome:REACT_6939
Binding of ATR-ATRIP to the RPA-ssDNA complex, Homo sapiens
Reactome:REACT_77532
Stalling of DNA replication fork and RPA binding, Canis familiaris
Reactome:REACT_79188
Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Canis familiaris
Reactome:REACT_79450
Activation of ATR in response to replication stress, Dictyostelium discoideum
Reactome:REACT_80432
Loading of claspin onto DNA during replication origin firing, Taeniopygia guttata
Reactome:REACT_80571
Activation of claspin, Mus musculus
Reactome:REACT_80896
Recruitment and activation of Chk1, Sus scrofa
Reactome:REACT_80988
Loading of claspin onto DNA during replication origin firing, Bos taurus
Reactome:REACT_81803
Recruitment of Rad17-RFC complex to DNA, Canis familiaris
Reactome:REACT_83095
Recruitment of Rad17-RFC complex to DNA, Danio rerio
Reactome:REACT_84829
Binding of ATR-ATRIP to the RPA-ssDNA complex, Danio rerio
Reactome:REACT_85561
Binding of ATR-ATRIP to the RPA-ssDNA complex, Rattus norvegicus
Reactome:REACT_86410
Stalling of DNA replication fork and RPA binding, Mus musculus
Reactome:REACT_86739
Recruitment and activation of Chk1, Rattus norvegicus
Reactome:REACT_87233
Binding of ATR-ATRIP to the RPA-ssDNA complex, Canis familiaris
Reactome:REACT_87449
Recruitment of Rad17-RFC complex to DNA, Rattus norvegicus
Reactome:REACT_87590
Recruitment of Rad17-RFC complex to DNA, Bos taurus
Reactome:REACT_88085
Binding of ATR-ATRIP to the RPA-ssDNA complex, Gallus gallus
Reactome:REACT_88384
Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Schizosaccharomyces pombe
Reactome:REACT_88529
Activation of claspin, Gallus gallus
Reactome:REACT_89355
Activation of claspin, Danio rerio
Reactome:REACT_89439
Activation of ATR in response to replication stress, Sus scrofa
Reactome:REACT_89725
Loading of claspin onto DNA during replication origin firing, Drosophila melanogaster
Reactome:REACT_90512
Stalling of DNA replication fork and RPA binding, Bos taurus
Reactome:REACT_90809
Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Danio rerio
Reactome:REACT_90838
Recruitment of Rad17-RFC complex to DNA, Taeniopygia guttata
Reactome:REACT_91184
Recruitment and activation of Chk1, Danio rerio
Reactome:REACT_91302
Activation of ATR in response to replication stress, Canis familiaris
Reactome:REACT_92527
Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Mus musculus
Reactome:REACT_92644
Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Xenopus tropicalis
Reactome:REACT_92706
Stalling of DNA replication fork and RPA binding, Danio rerio
Reactome:REACT_94983
Stalling of DNA replication fork and RPA binding, Xenopus tropicalis
Reactome:REACT_95253
Activation of ATR in response to replication stress, Taeniopygia guttata
Reactome:REACT_95329
Activation of claspin, Taeniopygia guttata
Reactome:REACT_96115
Binding of ATR-ATRIP to the RPA-ssDNA complex, Mus musculus
Reactome:REACT_96804
Recruitment and activation of Chk1, Mus musculus
Reactome:REACT_96998
Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Bos taurus
Reactome:REACT_97204
Loading of claspin onto DNA during replication origin firing, Gallus gallus
Reactome:REACT_97726
Activation of ATR in response to replication stress, Caenorhabditis elegans
Reactome:REACT_99948
Loading of claspin onto DNA during replication origin firing, Xenopus tropicalis
The process in which the number of copies of a gene is increased in certain cells as extra copies of DNA are made in response to certain signals of cell development or of stress from the environment.
biological_process
GO:0006277
DNA amplification
The process in which the number of copies of a gene is increased in certain cells as extra copies of DNA are made in response to certain signals of cell development or of stress from the environment.
ISBN:0721601464
A DNA replication process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands.
Reactome:REACT_6880
Reactome:REACT_9037
Reactome:REACT_9055
biological_process
GO:0006278
RNA-dependent DNA replication
A DNA replication process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands.
GOC:mah
ISBN:0198506732
Reactome:REACT_6880
Reverse Transcription of HIV RNA, Homo sapiens
Reactome:REACT_9037
Plus-strand DNA synthesis, Homo sapiens
Reactome:REACT_9055
Minus-strand DNA synthesis, Homo sapiens
The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.
DNA breakdown
DNA catabolism
DNA degradation
biological_process
GO:0006308
DNA catabolic process
The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.
GOC:go_curators
ISBN:0198506732
The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
GO:0008178
DNA fragmentation
chromatinolysis
Reactome:REACT_102783
Reactome:REACT_105342
Reactome:REACT_110358
Reactome:REACT_113418
Reactome:REACT_1213
Reactome:REACT_28808
Reactome:REACT_33113
Reactome:REACT_92967
Reactome:REACT_94135
Reactome:REACT_98713
Reactome:REACT_99275
Reactome:REACT_99925
DNA catabolic process during apoptosis
DNA catabolism during apoptosis
DNA fragmentation involved in apoptotic nuclear change
endonucleolytic DNA catabolic process involved in apoptosis
biological_process
GO:0006309
DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341).
apoptotic DNA fragmentation
The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
GOC:dph
GOC:mah
GOC:mtg_apoptosis
GOC:tb
ISBN:0721639976
PMID:15723341
PMID:23379520
chromatinolysis
GOC:mtg_apoptosis
Reactome:REACT_102783
Apoptosis induced DNA fragmentation, Bos taurus
Reactome:REACT_105342
Apoptosis induced DNA fragmentation, Sus scrofa
Reactome:REACT_110358
Apoptosis induced DNA fragmentation, Xenopus tropicalis
Reactome:REACT_113418
Apoptosis induced DNA fragmentation, Plasmodium falciparum
Reactome:REACT_1213
Apoptosis induced DNA fragmentation, Homo sapiens
Reactome:REACT_28808
Apoptosis induced DNA fragmentation, Rattus norvegicus
Reactome:REACT_33113
Apoptosis induced DNA fragmentation, Mus musculus
Reactome:REACT_92967
Apoptosis induced DNA fragmentation, Drosophila melanogaster
Reactome:REACT_94135
Apoptosis induced DNA fragmentation, Taeniopygia guttata
Reactome:REACT_98713
Apoptosis induced DNA fragmentation, Canis familiaris
Reactome:REACT_99275
Apoptosis induced DNA fragmentation, Gallus gallus
Reactome:REACT_99925
Apoptosis induced DNA fragmentation, Danio rerio
DNA fragmentation involved in apoptotic nuclear change
GOC:cjm
GOC:dph
GOC:tb
Any process in which DNA and associated proteins are formed into a compact, orderly structure.
DNA condensation
DNA organisation
DNA organization
biological_process
GO:0006323
DNA packaging
Any process in which DNA and associated proteins are formed into a compact, orderly structure.
GOC:mah
ISBN:0815316194
DNA organisation
GOC:curators
DNA organization
GOC:curators
The cellular synthesis of RNA on a template of DNA.
GO:0006350
GO:0061018
GO:0061022
cellular transcription
transcription
Wikipedia:Transcription_(genetics)
DNA-dependent transcription
cellular transcription, DNA-dependent
transcription, DNA-dependent
biological_process
transcription regulator activity
GO:0006351
transcription, DNA-templated
The cellular synthesis of RNA on a template of DNA.
GOC:jl
GOC:txnOH
transcription, DNA-dependent
GOC:txnOH
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
GO:0032583
GO:0045449
GO:0061019
transcriptional control
regulation of cellular transcription, DNA-dependent
regulation of transcription, DNA-dependent
biological_process
regulation of gene-specific transcription
GO:0006355
regulation of transcription, DNA-templated
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
GOC:go_curators
GOC:txnOH
regulation of transcription, DNA-dependent
GOC:txnOH
The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
Wikipedia:Protein_targeting
protein sorting along secretory pathway
biological_process
nascent polypeptide association
GO:0006605
Note that protein targeting encompasses the transport of the protein to the specified location, and may also include additional steps such as protein processing.
protein targeting
The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
GOC:ma
The directed movement of a protein from the cytoplasm to the nucleus.
establishment of protein localization to nucleus
protein import into cell nucleus
protein nucleus import
protein transport from cytoplasm to nucleus
biological_process
GO:0006606
protein import into nucleus
The directed movement of a protein from the cytoplasm to the nucleus.
GOC:jl
establishment of protein localization to nucleus
GOC:mah
The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.
aromatic compound metabolism
aromatic hydrocarbon metabolic process
aromatic hydrocarbon metabolism
biological_process
GO:0006725
cellular aromatic compound metabolic process
The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.
GOC:ai
ISBN:0198506732
The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.
nitrogen compound metabolism
biological_process
GO:0006807
Note that amino acid and derivative metabolism should not be annotated here. Instead use the 'amino acid and derivative metabolism' node.
nitrogen compound metabolic process
The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.
CHEBI:51143
GOC:go_curators
GOC:jl
ISBN:0198506732
The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.
GO:0015457
GO:0015460
small molecule transport
solute:solute exchange
biological_process
auxiliary transport protein activity
transport accessory protein activity
GO:0006810
transport
The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.
GOC:dph
GOC:jl
GOC:mah
auxiliary transport protein activity
GOC:mah
transport accessory protein activity
GOC:mah
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
GO:0032779
biological_process
copper-induced intracellular protein transport
GO:0006886
intracellular protein transport
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
GOC:mah
copper-induced intracellular protein transport
GOC:al
The directed movement of molecules between the nucleus and the cytoplasm.
GO:0000063
nucleocytoplasmic shuttling
biological_process
GO:0006913
Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane, and is not traversed.
nucleocytoplasmic transport
The directed movement of molecules between the nucleus and the cytoplasm.
GOC:go_curators
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
GO:0006917
GO:0008632
cell suicide
cellular suicide
Reactome:REACT_100045
Reactome:REACT_100962
Reactome:REACT_101249
Reactome:REACT_104187
Reactome:REACT_105149
Reactome:REACT_106405
Reactome:REACT_106672
Reactome:REACT_107264
Reactome:REACT_108651
Reactome:REACT_109165
Reactome:REACT_110081
Reactome:REACT_111964
Reactome:REACT_13526
Reactome:REACT_13638
Reactome:REACT_13643
Reactome:REACT_28087
Reactome:REACT_28795
Reactome:REACT_28816
Reactome:REACT_30266
Reactome:REACT_30361
Reactome:REACT_30371
Reactome:REACT_30548
Reactome:REACT_30763
Reactome:REACT_31349
Reactome:REACT_34139
Reactome:REACT_578
Reactome:REACT_77132
Reactome:REACT_77313
Reactome:REACT_77415
Reactome:REACT_78287
Reactome:REACT_78802
Reactome:REACT_79809
Reactome:REACT_82724
Reactome:REACT_83328
Reactome:REACT_85877
Reactome:REACT_86749
Reactome:REACT_86873
Reactome:REACT_87570
Reactome:REACT_88740
Reactome:REACT_88784
Reactome:REACT_89196
Reactome:REACT_90267
Reactome:REACT_91011
Reactome:REACT_91243
Reactome:REACT_93937
Reactome:REACT_94099
Reactome:REACT_95069
Reactome:REACT_95675
Reactome:REACT_97627
Reactome:REACT_99784
Reactome:REACT_99799
Wikipedia:Apoptosis
apoptotic cell death
apoptotic programmed cell death
programmed cell death by apoptosis
activation of apoptosis
apoptosis
apoptosis signaling
apoptotic program
type I programmed cell death
biological_process
apoptosis activator activity
commitment to apoptosis
induction of apoptosis
induction of apoptosis by p53
signaling (initiator) caspase activity
GO:0006915
apoptotic process
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
GOC:dhl
GOC:ecd
GOC:go_curators
GOC:mtg_apoptosis
GOC:tb
ISBN:0198506732
PMID:18846107
PMID:21494263
Reactome:REACT_100045
Apoptosis, Drosophila melanogaster
Reactome:REACT_100962
Apoptosis, Mus musculus
Reactome:REACT_101249
NRIF signals cell death from the nucleus, Danio rerio
Reactome:REACT_104187
NRAGE signals death through JNK, Taeniopygia guttata
Reactome:REACT_105149
NADE modulates death signalling, Rattus norvegicus
Reactome:REACT_106405
NRAGE signals death through JNK, Xenopus tropicalis
Reactome:REACT_106672
NADE modulates death signalling, Sus scrofa
Reactome:REACT_107264
NRIF signals cell death from the nucleus, Xenopus tropicalis
Reactome:REACT_108651
NRAGE signals death through JNK, Mus musculus
Reactome:REACT_109165
NRAGE signals death through JNK, Arabidopsis thaliana
Reactome:REACT_110081
NRAGE signals death through JNK, Schizosaccharomyces pombe
Reactome:REACT_111964
NRAGE signals death through JNK, Dictyostelium discoideum
Reactome:REACT_13526
NADE modulates death signalling, Homo sapiens
Reactome:REACT_13638
NRAGE signals death through JNK, Homo sapiens
Reactome:REACT_13643
NRIF signals cell death from the nucleus, Homo sapiens
Reactome:REACT_28087
Apoptosis, Saccharomyces cerevisiae
Reactome:REACT_28795
Apoptosis, Oryza sativa
Reactome:REACT_28816
Apoptosis, Danio rerio
Reactome:REACT_30266
Apoptosis, Arabidopsis thaliana
Reactome:REACT_30361
Apoptosis, Canis familiaris
Reactome:REACT_30371
NRAGE signals death through JNK, Saccharomyces cerevisiae
Reactome:REACT_30548
NRAGE signals death through JNK, Caenorhabditis elegans
Reactome:REACT_30763
NRAGE signals death through JNK, Oryza sativa
Reactome:REACT_31349
NRAGE signals death through JNK, Canis familiaris
Reactome:REACT_34139
NRAGE signals death through JNK, Gallus gallus
Reactome:REACT_578
Apoptosis, Homo sapiens
Reactome:REACT_77132
NRAGE signals death through JNK, Drosophila melanogaster
Reactome:REACT_77313
NADE modulates death signalling, Bos taurus
Reactome:REACT_77415
NRIF signals cell death from the nucleus, Canis familiaris
Reactome:REACT_78287
Apoptosis, Gallus gallus
Reactome:REACT_78802
NADE modulates death signalling, Canis familiaris
Reactome:REACT_79809
Apoptosis, Schizosaccharomyces pombe
Reactome:REACT_82724
Apoptosis, Taeniopygia guttata
Reactome:REACT_83328
Apoptosis, Sus scrofa
Reactome:REACT_85877
NRAGE signals death through JNK, Rattus norvegicus
Reactome:REACT_86749
Apoptosis, Rattus norvegicus
Reactome:REACT_86873
NRIF signals cell death from the nucleus, Gallus gallus
Reactome:REACT_87570
NRIF signals cell death from the nucleus, Rattus norvegicus
Reactome:REACT_88740
NRIF signals cell death from the nucleus, Sus scrofa
Reactome:REACT_88784
NRIF signals cell death from the nucleus, Mus musculus
Reactome:REACT_89196
Apoptosis, Dictyostelium discoideum
Reactome:REACT_90267
NRIF signals cell death from the nucleus, Taeniopygia guttata
Reactome:REACT_91011
Apoptosis, Caenorhabditis elegans
Reactome:REACT_91243
NADE modulates death signalling, Mus musculus
Reactome:REACT_93937
Apoptosis, Bos taurus
Reactome:REACT_94099
NRAGE signals death through JNK, Danio rerio
Reactome:REACT_95069
Apoptosis, Xenopus tropicalis
Reactome:REACT_95675
Apoptosis, Plasmodium falciparum
Reactome:REACT_97627
NRIF signals cell death from the nucleus, Bos taurus
Reactome:REACT_99784
NRAGE signals death through JNK, Bos taurus
Reactome:REACT_99799
NRAGE signals death through JNK, Sus scrofa
apoptotic cell death
GOC:sl
apoptotic program
GOC:add
The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis.
cellular component disassembly involved in apoptotic process
disassembly of cell structures
Reactome:REACT_100800
Reactome:REACT_108463
Reactome:REACT_29660
Reactome:REACT_77151
Reactome:REACT_78666
Reactome:REACT_79472
Reactome:REACT_79859
Reactome:REACT_80493
Reactome:REACT_81021
Reactome:REACT_81052
Reactome:REACT_84120
Reactome:REACT_89424
Reactome:REACT_90988
Reactome:REACT_92689
Reactome:REACT_93576
Reactome:REACT_94230
Reactome:REACT_97703
Reactome:REACT_995
cellular component disassembly involved in apoptosis
biological_process
GO:0006921
cellular component disassembly involved in execution phase of apoptosis
The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis.
GOC:dph
GOC:mah
GOC:mtg_apoptosis
GOC:tb
Reactome:REACT_100800
Apoptotic execution phase, Danio rerio
Reactome:REACT_108463
Apoptotic execution phase, Taeniopygia guttata
Reactome:REACT_29660
Apoptotic execution phase, Oryza sativa
Reactome:REACT_77151
Apoptotic execution phase, Sus scrofa
Reactome:REACT_78666
Apoptotic execution phase, Saccharomyces cerevisiae
Reactome:REACT_79472
Apoptotic execution phase, Schizosaccharomyces pombe
Reactome:REACT_79859
Apoptotic execution phase, Rattus norvegicus
Reactome:REACT_80493
Apoptotic execution phase, Dictyostelium discoideum
Reactome:REACT_81021
Apoptotic execution phase, Drosophila melanogaster
Reactome:REACT_81052
Apoptotic execution phase, Canis familiaris
Reactome:REACT_84120
Apoptotic execution phase, Xenopus tropicalis
Reactome:REACT_89424
Apoptotic execution phase, Arabidopsis thaliana
Reactome:REACT_90988
Apoptotic execution phase, Plasmodium falciparum
Reactome:REACT_92689
Apoptotic execution phase, Caenorhabditis elegans
Reactome:REACT_93576
Apoptotic execution phase, Gallus gallus
Reactome:REACT_94230
Apoptotic execution phase, Bos taurus
Reactome:REACT_97703
Apoptotic execution phase, Mus musculus
Reactome:REACT_995
Apoptotic execution phase, Homo sapiens
The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore.
cellular component motion
cellular component movement
biological_process
cell movement
GO:0006928
Note that in GO cellular components include whole cells (cell is_a cellular component).
movement of cell or subcellular component
The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore.
GOC:dgh
GOC:dph
GOC:jl
GOC:mlg
cellular component motion
GOC:dph
GOC:jl
The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate.
substrate-bound cell migration
biological_process
GO:0006929
substrate-dependent cell migration
The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate.
ISBN:0815316194
PMID:11944043
PMID:14657486
substrate-bound cell migration
GOC:curators
The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell.
substrate-bound cell migration, cell extension
biological_process
GO:0006930
substrate-dependent cell migration, cell extension
The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell.
ISBN:0815316194
PMID:11944043
PMID:14657486
substrate-bound cell migration, cell extension
GOC:curators
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
biological_process
response to abiotic stress
response to biotic stress
GO:0006950
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
response to stress
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
GOC:mah
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
biological_process
GO:0006955
This term was improved by GO_REF:0000022. It was redefined and moved.
immune response
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
GOC:add
GOC:mtg_15nov05
GO_REF:0000022
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
GO:0034984
response to DNA damage stimulus
DNA damage response
cellular DNA damage response
response to genotoxic stress
biological_process
GO:0006974
cellular response to DNA damage stimulus
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
GOC:go_curators
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
organelle organisation
biological_process
organelle organization and biogenesis
GO:0006996
organelle organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
GOC:mah
organelle organisation
GOC:curators
organelle organization and biogenesis
GOC:dph
GOC:jl
GOC:mah
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.
GO:0048287
nuclear organisation
nuclear organization
biological_process
nuclear morphology
nuclear organization and biogenesis
nucleus organization and biogenesis
GO:0006997
nucleus organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.
GOC:dph
GOC:ems
GOC:jl
GOC:mah
nuclear organisation
GOC:curators
nuclear organization
GOC:curators
nuclear organization and biogenesis
GOC:mah
nucleus organization and biogenesis
GOC:mah
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope.
nuclear envelope organisation
biological_process
nuclear envelope organization and biogenesis
GO:0006998
nuclear envelope organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope.
GOC:dph
GOC:ems
GOC:jl
GOC:mah
nuclear envelope organisation
GOC:mah
nuclear envelope organization and biogenesis
GOC:mah
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.
plasma membrane organisation
biological_process
plasma membrane organization and biogenesis
GO:0007009
plasma membrane organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.
GOC:dph
GOC:jl
GOC:mah
plasma membrane organisation
GOC:curators
plasma membrane organization and biogenesis
GOC:mah
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
cytoskeleton organisation
biological_process
cytoskeletal organization and biogenesis
cytoskeletal regulator activity
cytoskeleton organization and biogenesis
GO:0007010
cytoskeleton organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
GOC:dph
GOC:jl
GOC:mah
cytoskeleton organisation
GOC:curators
cytoskeletal organization and biogenesis
GOC:mah
cytoskeleton organization and biogenesis
GOC:mah
Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
biological_process
GO:0007017
microtubule-based process
Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
GOC:mah
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum.
ER organisation
endoplasmic reticulum organisation
biological_process
ER organization and biogenesis
endoplasmic reticulum morphology
endoplasmic reticulum organization and biogenesis
GO:0007029
endoplasmic reticulum organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum.
GOC:dph
GOC:jl
GOC:mah
ER organisation
GOC:curators
endoplasmic reticulum organisation
GOC:curators
ER organization and biogenesis
GOC:mah
endoplasmic reticulum organization and biogenesis
GOC:mah
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
peroxisome organisation
biological_process
peroxisome organization and biogenesis
peroxisome-assembly ATPase activity
GO:0007031
peroxisome organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
GOC:mah
peroxisome organisation
GOC:curators
peroxisome organization and biogenesis
GOC:mah
The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
Wikipedia:Cell_cycle
cell-division cycle
biological_process
GO:0007049
cell cycle
The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
GOC:go_curators
GOC:mtg_cell_cycle
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
Wikipedia:Chromosome_segregation
chromosome division
biological_process
chromosome transmission
GO:0007059
chromosome segregation
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
GOC:jl
GOC:mah
GOC:mtg_cell_cycle
GOC:vw
A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
Wikipedia:Mitosis
mitosis
biological_process
GO:0007067
mitotic nuclear division
A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
GOC:dph
GOC:ma
GOC:mah
ISBN:0198547684
The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
biological_process
GO:0007076
mitotic chromosome condensation
The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
GOC:mah
ISBN:0815316194
The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis.
biological_process
GO:0007080
mitotic metaphase plate congression
The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis.
GOC:mah
ISBN:0815316194
The cell cycle process in which chromosome structure is altered from the condensed form taken on during mitosis to the relaxed disperse form held in resting cells.
biological_process
GO:0007083
mitotic chromosome decondensation
The cell cycle process in which chromosome structure is altered from the condensed form taken on during mitosis to the relaxed disperse form held in resting cells.
GOC:ai
The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle.
biological_process
GO:0007098
centrosome cycle
The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle.
ISBN:0815316194
The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type.
centriole duplication
biological_process
GO:0007099
centriole replication
The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type.
GOC:kmv
ISBN:0815316194
Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
Wikipedia:Cell_signaling
biological_process
GO:0007154
cell communication
Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
GOC:mah
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
Wikipedia:Cell_adhesion
biological_process
cell adhesion molecule activity
GO:0007155
cell adhesion
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
GOC:hb
GOC:pf
The binding of a cell to the extracellular matrix via adhesion molecules.
biological_process
GO:0007160
cell-matrix adhesion
The binding of a cell to the extracellular matrix via adhesion molecules.
GOC:hb
Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
GO:0030012
GO:0030467
biological_process
cell polarity
establishment and/or maintenance of cell polarity
establishment and/or maintenance of cell polarization
GO:0007163
establishment or maintenance of cell polarity
Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
GOC:mah
cell polarity
GOC:mah
GOC:vw
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
GO:0023033
Reactome:REACT_100624
Reactome:REACT_102354
Reactome:REACT_112130
Reactome:REACT_112549
Reactome:REACT_113151
Reactome:REACT_113601
Reactome:REACT_113964
Reactome:REACT_114657
Reactome:REACT_114690
Reactome:REACT_114820
Reactome:REACT_114910
Reactome:REACT_115037
Reactome:REACT_115147
Reactome:REACT_12478
Reactome:REACT_31232
Reactome:REACT_78535
Reactome:REACT_89740
Reactome:REACT_93680
Reactome:REACT_98872
Wikipedia:Signal_transduction
signaling cascade
signalling cascade
biological_process
signaling pathway
signalling pathway
GO:0007165
Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.
signal transduction
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
GOC:go_curators
GOC:mtg_signaling_feb11
Reactome:REACT_100624
EGFR interacts with phospholipase C-gamma, Gallus gallus
Reactome:REACT_102354
EGFR interacts with phospholipase C-gamma, Canis familiaris
Reactome:REACT_112130
EGFR interacts with phospholipase C-gamma, Oryza sativa
Reactome:REACT_112549
EGFR interacts with phospholipase C-gamma, Arabidopsis thaliana
Reactome:REACT_113151
EGFR interacts with phospholipase C-gamma, Mycobacterium tuberculosis
Reactome:REACT_113601
EGFR interacts with phospholipase C-gamma, Drosophila melanogaster
Reactome:REACT_113964
EGFR interacts with phospholipase C-gamma, Bos taurus
Reactome:REACT_114657
EGFR interacts with phospholipase C-gamma, Dictyostelium discoideum
Reactome:REACT_114690
EGFR interacts with phospholipase C-gamma, Saccharomyces cerevisiae
Reactome:REACT_114820
EGFR interacts with phospholipase C-gamma, Sus scrofa
Reactome:REACT_114910
EGFR interacts with phospholipase C-gamma, Caenorhabditis elegans
Reactome:REACT_115037
EGFR interacts with phospholipase C-gamma, Plasmodium falciparum
Reactome:REACT_115147
EGFR interacts with phospholipase C-gamma, Schizosaccharomyces pombe
Reactome:REACT_12478
EGFR interacts with phospholipase C-gamma, Homo sapiens
Reactome:REACT_31232
EGFR interacts with phospholipase C-gamma, Rattus norvegicus
Reactome:REACT_78535
EGFR interacts with phospholipase C-gamma, Xenopus tropicalis
Reactome:REACT_89740
EGFR interacts with phospholipase C-gamma, Taeniopygia guttata
Reactome:REACT_93680
EGFR interacts with phospholipase C-gamma, Danio rerio
Reactome:REACT_98872
EGFR interacts with phospholipase C-gamma, Mus musculus
signalling pathway
GOC:mah
The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
NF-kappaB cascade
Reactome:REACT_13696.1
Reactome:REACT_25351
I-kappaB kinase/NF-kappaB signal transduction
canonical NF-kappaB signaling cascade
biological_process
I-kappaB kinase/NF-kappaB cascade
activation of the inhibitor of kappa kinase
p50-dependent NF-kappaB signaling
GO:0007249
I-kappaB kinase/NF-kappaB signaling
The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
GOC:bf
GOC:jl
PMID:12773372
Reactome:REACT_13696.1
Reactome:REACT_13696.1
NF-kB is activated and signals survival, Homo sapiens
Reactome:REACT_25351
TRAF6 mediated induction of TAK1 complex, Homo sapiens
I-kappaB kinase/NF-kappaB signal transduction
GOC:signaling
canonical NF-kappaB signaling cascade
GOC:bf
I-kappaB kinase/NF-kappaB cascade
GOC:signaling
p50-dependent NF-kappaB signaling
PMID:18292232
The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.
cytoplasmic NF-kappaB retention
cytoplasmic NF-kappaB sequestration
cytoplasmic NF-kappaB storage
cytoplasmic retention of NF-kappaB
cytoplasmic sequestration of NF-kappaB
cytoplasmic storage of NF-kappaB
maintenance of NF-kappaB location in cytoplasm
biological_process
GO:0007253
cytoplasmic sequestering of NF-kappaB
The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.
GOC:jl
maintenance of NF-kappaB location in cytoplasm
GOC:dph
GOC:tb
Any process in which a protein is transported to, or maintained in, a specific location.
establishment and maintenance of protein localization
protein localisation
biological_process
GO:0008104
protein localization
Any process in which a protein is transported to, or maintained in, a specific location.
GOC:ai
protein localisation
GOC:mah
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0000004
GO:0007582
Wikipedia:Biological_process
biological process
physiological process
biological_process
GO:0008150
Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. Note that when this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GOC:go_curators
GOC:isa_complete
The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
Wikipedia:Metabolism
metabolism
metabolic process resulting in cell growth
metabolism resulting in cell growth
biological_process
GO:0008152
Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions.
metabolic process
The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GOC:go_curators
ISBN:0198547684
Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as "apoptotic bodies"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo.
biological_process
accidental cell death
necrosis
GO:0008219
This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term.
cell death
Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as "apoptotic bodies"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo.
GOC:mah
GOC:mtg_apoptosis
The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.
DNA bending activity
DNA bending involving DNA binding
molecular_function
GO:0008301
DNA binding, bending
The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.
GOC:krc
GOC:vw
PMID:10710711
PMID:19037758
The release of NF-kappaB from specific molecules in the cytoplasm to which it was bound, thereby allowing its translocation into the nucleus.
release of NF-kappaB sequestered in cytoplasm
release of NF-kappaB stored in cytoplasm
biological_process
activation of NF-kappa B
negative regulation of cytoplasmic NF-kappaB retention
negative regulation of cytoplasmic NF-kappaB sequestering
negative regulation of cytoplasmic NF-kappaB sequestration
negative regulation of cytoplasmic NF-kappaB storage
GO:0008588
release of cytoplasmic sequestered NF-kappaB
The release of NF-kappaB from specific molecules in the cytoplasm to which it was bound, thereby allowing its translocation into the nucleus.
GOC:jl
The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
Wikipedia:Catabolism
breakdown
catabolism
degradation
biological_process
GO:0009056
catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
ISBN:0198547684
The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
GO:0043285
biopolymer catabolic process
macromolecule breakdown
macromolecule catabolism
macromolecule degradation
biological_process
GO:0009057
macromolecule catabolic process
The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
CHEBI:33694
GOC:mah
biopolymer catabolic process
GOC:mtg_chebi_dec09
The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
Wikipedia:Anabolism
anabolism
biosynthesis
formation
synthesis
biological_process
GO:0009058
biosynthetic process
The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
GOC:curators
ISBN:0198547684
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
GO:0043284
biopolymer biosynthetic process
macromolecule anabolism
macromolecule biosynthesis
macromolecule formation
macromolecule synthesis
biological_process
GO:0009059
macromolecule biosynthetic process
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
CHEBI:33694
GOC:mah
biopolymer biosynthetic process
GOC:mtg_chebi_dec09
The controlled release of proteins from a cell.
GO:0045166
GO:0045731
glycoprotein secretion
protein secretion during cell fate commitment
protein secretion resulting in cell fate commitment
biological_process
GO:0009306
protein secretion
The controlled release of proteins from a cell.
GOC:ai
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.
response to biotic stress
biological_process
GO:0009607
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
response to biotic stimulus
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.
GOC:hb
The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
embryogenesis and morphogenesis
Wikipedia:Morphogenesis
anatomical structure organization
morphogenesis
biological_process
GO:0009653
anatomical structure morphogenesis
The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
GOC:go_curators
ISBN:0521436125
The process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell.
cell growth along one axis
cell growth in one dimension
cell morphogenesis by unidimensional growth
polar cell growth
polarized cell growth
cell elongation
biological_process
GO:0009826
Unidimensional cell growth refers to a change in both cell size and cell shape. For cell shape changes where cell size is not affected, consider instead the term 'regulation of cell shape ; GO:0008360' and its children.
unidimensional cell growth
The process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell.
ISBN:0943088399
cell morphogenesis by unidimensional growth
GOC:dph
GOC:tb
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
regulation of anabolism
regulation of biosynthesis
regulation of formation
regulation of synthesis
biological_process
GO:0009889
regulation of biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
GOC:go_curators
Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.
down regulation of biosynthetic process
down-regulation of biosynthetic process
downregulation of biosynthetic process
negative regulation of anabolism
negative regulation of biosynthesis
negative regulation of formation
negative regulation of synthesis
inhibition of biosynthetic process
biological_process
GO:0009890
negative regulation of biosynthetic process
Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.
GOC:go_curators
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
positive regulation of anabolism
positive regulation of biosynthesis
positive regulation of formation
positive regulation of synthesis
up regulation of biosynthetic process
up-regulation of biosynthetic process
upregulation of biosynthetic process
activation of biosynthetic process
stimulation of biosynthetic process
biological_process
GO:0009891
positive regulation of biosynthetic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
GOC:go_curators
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
down regulation of metabolic process
down-regulation of metabolic process
downregulation of metabolic process
negative regulation of metabolism
inhibition of metabolic process
biological_process
GO:0009892
negative regulation of metabolic process
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GOC:go_curators
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
positive regulation of metabolism
up regulation of metabolic process
up-regulation of metabolic process
upregulation of metabolic process
activation of metabolic process
stimulation of metabolic process
biological_process
GO:0009893
positive regulation of metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GOC:go_curators
Any process that modulates the frequency, rate or extent of signal transduction.
GO:0035466
biological_process
regulation of signaling pathway
regulation of signalling pathway
GO:0009966
regulation of signal transduction
Any process that modulates the frequency, rate or extent of signal transduction.
GOC:sm
regulation of signalling pathway
GOC:mah
Any process that activates or increases the frequency, rate or extent of signal transduction.
GO:0035468
Reactome:REACT_6227
up regulation of signal transduction
up-regulation of signal transduction
upregulation of signal transduction
activation of signal transduction
stimulation of signal transduction
biological_process
positive regulation of signaling pathway
positive regulation of signalling pathway
GO:0009967
positive regulation of signal transduction
Any process that activates or increases the frequency, rate or extent of signal transduction.
GOC:sm
Reactome:REACT_6227
Activated DTOR also phosphorylates D4EBP, Drosophila melanogaster
positive regulation of signalling pathway
GOC:mah
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.
GO:0035467
Reactome:REACT_6334
down regulation of signal transduction
down-regulation of signal transduction
downregulation of signal transduction
inhibition of signal transduction
biological_process
negative regulation of signaling pathway
negative regulation of signalling pathway
GO:0009968
negative regulation of signal transduction
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.
GOC:sm
Reactome:REACT_6334
DTSC1 AND DTSC2 form a complex, Drosophila melanogaster
negative regulation of signalling pathway
GOC:mah
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0008151
GO:0050875
cell physiology
cellular physiological process
cell growth and/or maintenance
biological_process
GO:0009987
cellular process
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GOC:go_curators
GOC:isa_complete
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system.
endomembrane organization
endomembrane system organisation
biological_process
GO:0010256
endomembrane system organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system.
GOC:mah
GOC:sm
endomembrane organization
GOC:curators
endomembrane system organisation
GOC:mah
The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place.
mitotic exit
biological_process
GO:0010458
exit from mitosis
The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place.
GOC:dph
GOC:tb
The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
Reactome:REACT_100537
Reactome:REACT_101147
Reactome:REACT_101952
Reactome:REACT_105649
Reactome:REACT_108313
Reactome:REACT_29068
Reactome:REACT_34240
Reactome:REACT_71
Reactome:REACT_78136
Reactome:REACT_78959
Reactome:REACT_79662
Reactome:REACT_85241
Reactome:REACT_85359
Reactome:REACT_86357
Reactome:REACT_89816
Reactome:REACT_91657
Reactome:REACT_91965
Reactome:REACT_93586
Reactome:REACT_93968
Reactome:REACT_94814
Reactome:REACT_98256
Wikipedia:Gene_expression
biological_process
GO:0010467
gene expression
The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
GOC:dph
GOC:tb
Reactome:REACT_100537
Gene Expression, Xenopus tropicalis
Reactome:REACT_101147
Gene Expression, Danio rerio
Reactome:REACT_101952
Gene Expression, Sus scrofa
Reactome:REACT_105649
Gene Expression, Drosophila melanogaster
Reactome:REACT_108313
Gene Expression, Caenorhabditis elegans
Reactome:REACT_29068
Gene Expression, Escherichia coli
Reactome:REACT_34240
Gene Expression, Staphylococcus aureus N315
Reactome:REACT_71
Gene Expression, Homo sapiens
Reactome:REACT_78136
Gene Expression, Mus musculus
Reactome:REACT_78959
Gene Expression, Taeniopygia guttata
Reactome:REACT_79662
Gene Expression, Plasmodium falciparum
Reactome:REACT_85241
Gene Expression, Oryza sativa
Reactome:REACT_85359
Gene Expression, Gallus gallus
Reactome:REACT_86357
Gene Expression, Canis familiaris
Reactome:REACT_89816
Gene Expression, Mycobacterium tuberculosis
Reactome:REACT_91657
Gene Expression, Arabidopsis thaliana
Reactome:REACT_91965
Gene Expression, Rattus norvegicus
Reactome:REACT_93586
Gene Expression, Dictyostelium discoideum
Reactome:REACT_93968
Gene Expression, Bos taurus
Reactome:REACT_94814
Gene Expression, Schizosaccharomyces pombe
Reactome:REACT_98256
Gene Expression, Saccharomyces cerevisiae
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
Wikipedia:Regulation_of_gene_expression
regulation of protein expression
biological_process
regulation of gene product expression
GO:0010468
This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availabiliy of mRNA for translation and thereby regulates the rate of production of the encoded protein via translation.
regulation of gene expression
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
GOC:dph
GOC:tb
regulation of protein expression
GOC:curators
regulation of gene product expression
GOC:curators
Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
biological_process
GO:0010556
regulation of macromolecule biosynthetic process
Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
GOC:dph
GOC:tb
Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
biological_process
GO:0010557
positive regulation of macromolecule biosynthetic process
Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
GOC:dph
GOC:tb
Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
biological_process
GO:0010558
negative regulation of macromolecule biosynthetic process
Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
GOC:dph
GOC:tb
Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
biological_process
GO:0010604
positive regulation of macromolecule metabolic process
Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
GOC:dph
GOC:tb
Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
biological_process
GO:0010605
negative regulation of macromolecule metabolic process
Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
GOC:dph
GOC:tb
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
biological_process
GO:0010628
positive regulation of gene expression
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
GOC:dph
GOC:tb
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
biological_process
GO:0010629
This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availabiliy of mRNA for translation and thereby reduces the rate of production of the encoded protein via translation.
negative regulation of gene expression
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
GOC:dph
GOC:tb
Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
biological_process
GO:0010646
regulation of cell communication
Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
GOC:dph
GOC:tb
Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
biological_process
GO:0010647
positive regulation of cell communication
Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
GOC:dph
GOC:tb
Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
biological_process
GO:0010648
negative regulation of cell communication
Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
GOC:dph
GOC:tb
A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
GO:0016244
Wikipedia:Programmed_cell_death
PCD
caspase-independent cell death
non-apoptotic programmed cell death
nonapoptotic programmed cell death
biological_process
caspase-independent apoptosis
regulated cell death
GO:0012501
Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children, which are descendants of GO:0034050 'host programmed cell death induced by symbiont'.
programmed cell death
A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
GOC:lr
GOC:mtg_apoptosis
A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
Wikipedia:Endomembrane_system
cellular_component
GO:0012505
endomembrane system
A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
GOC:lh
A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.
NIF_Subcellular:nlx_subcell_090901
Wikipedia:Cajal_body
coiled body
cellular_component
Gemini of coiled bodies
Gems
GO:0015030
Cajal body
A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.
NIF_Subcellular:nlx_subcell_090901
PMID:10944589
PMID:11031238
PMID:7559785
The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0015831
enzyme transport
biological_process
GO:0015031
protein transport
The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GOC:ai
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
cellular_component
GO:0015629
actin cytoskeleton
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
GOC:jl
ISBN:0395825172
ISBN:0815316194
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
cellular_component
GO:0015630
microtubule cytoskeleton
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
GOC:jl
ISBN:0395825172
The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
biological_process
GO:0015833
peptide transport
The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GOC:ai
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
Wikipedia:Biological_membrane
cellular_component
GO:0016020
membrane
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
GOC:dos
GOC:mah
ISBN:0815316194
A membrane-bounded vesicle found in the cytoplasm of the cell.
cytoplasmic membrane bounded vesicle
cytoplasmic membrane-enclosed vesicle
cellular_component
GO:0016023
cytoplasmic membrane-bounded vesicle
A membrane-bounded vesicle found in the cytoplasm of the cell.
GOC:ai
GOC:mah
A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
GO:0044235
GO:0071842
cell organisation
cellular component organisation at cellular level
cellular component organisation in other organism
cellular component organization at cellular level
cellular component organization in other organism
biological_process
cell organization and biogenesis
GO:0016043
cellular component organization
A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
GOC:ai
GOC:jl
GOC:mah
cellular component organisation at cellular level
GOC:mah
cellular component organisation in other organism
GOC:mah
cell organization and biogenesis
GOC:mah
The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
GO:0048591
cellular growth
growth of cell
biological_process
cell expansion
metabolic process resulting in cell growth
metabolism resulting in cell growth
non-developmental cell growth
non-developmental growth of a unicellular organism
GO:0016049
cell growth
The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
GOC:ai
non-developmental cell growth
GOC:mah
non-developmental growth of a unicellular organism
GOC:mah
The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
Reactome:REACT_107259
Reactome:REACT_107652
Reactome:REACT_110289
Reactome:REACT_21257
Reactome:REACT_30579
Reactome:REACT_31367
Reactome:REACT_33720
Reactome:REACT_80071
Reactome:REACT_83630
Reactome:REACT_84169
Reactome:REACT_85788
Reactome:REACT_88316
Reactome:REACT_89992
Reactome:REACT_91556
Reactome:REACT_92152
Reactome:REACT_94876
Reactome:REACT_99403
Reactome:REACT_99885
RNA metabolism
biological_process
GO:0016070
RNA metabolic process
The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
ISBN:0198506732
Reactome:REACT_107259
Metabolism of RNA, Sus scrofa
Reactome:REACT_107652
Metabolism of RNA, Schizosaccharomyces pombe
Reactome:REACT_110289
Metabolism of RNA, Danio rerio
Reactome:REACT_21257
Metabolism of RNA, Homo sapiens
Reactome:REACT_30579
Metabolism of RNA, Xenopus tropicalis
Reactome:REACT_31367
Metabolism of RNA, Dictyostelium discoideum
Reactome:REACT_33720
Metabolism of RNA, Plasmodium falciparum
Reactome:REACT_80071
Metabolism of RNA, Caenorhabditis elegans
Reactome:REACT_83630
Metabolism of RNA, Taeniopygia guttata
Reactome:REACT_84169
Metabolism of RNA, Canis familiaris
Reactome:REACT_85788
Metabolism of RNA, Oryza sativa
Reactome:REACT_88316
Metabolism of RNA, Mus musculus
Reactome:REACT_89992
Metabolism of RNA, Saccharomyces cerevisiae
Reactome:REACT_91556
Metabolism of RNA, Bos taurus
Reactome:REACT_92152
Metabolism of RNA, Drosophila melanogaster
Reactome:REACT_94876
Metabolism of RNA, Arabidopsis thaliana
Reactome:REACT_99403
Metabolism of RNA, Rattus norvegicus
Reactome:REACT_99885
Metabolism of RNA, Gallus gallus
A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.
Wikipedia:Death
biological_process
GO:0016265
This term should not be used for direct manual annotation. Instead, consider selecting a child term of GO:0008219 'cell death' or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
death
A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.
GOC:mah
GOC:mtg_apoptosis
ISBN:0877797099
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
Wikipedia:Cell_migration
biological_process
GO:0016477
cell migration
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
GOC:cjm
GOC:dph
GOC:ems
GOC:pf
http://en.wikipedia.org/wiki/Cell_migration
The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell.
cytoplasmic streaming
biological_process
GO:0016482
cytoplasmic transport
The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell.
GOC:ai
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
NIF_Subcellular:sao505137457
cellular_component
GO:0016604
nuclear body
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
GOC:ma
PMID:10330182
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
ND10
PML NB
PML nuclear body
cellular_component
nuclear dot
GO:0016605
PML body
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
GOC:ma
PMID:10944585
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nuclear speckle
nuclear speckles
splicing speckle
speckle domain
cellular_component
speckle focus
GO:0016607
nuclear speck
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
http://www.cellnucleus.com/
Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
EC:2
Reactome:REACT_25050
molecular_function
GO:0016740
transferase activity
Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
ISBN:0198506732
Reactome:REACT_25050
Molybdenum ion transfer onto molybdopterin, Homo sapiens
Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).
EC:2.7
molecular_function
GO:0016772
Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides.
transferase activity, transferring phosphorus-containing groups
Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).
GOC:jl
ISBN:0198506732
Catalysis of the transfer of a nucleotidyl group to a reactant.
EC:2.7.7
molecular_function
GO:0016779
nucleotidyltransferase activity
Catalysis of the transfer of a nucleotidyl group to a reactant.
ISBN:0198506732
Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
EC:3
Reactome:REACT_110436
Reactome:REACT_111159
Reactome:REACT_15331
Reactome:REACT_83734
Reactome:REACT_84047
Reactome:REACT_87959
Reactome:REACT_88159
Reactome:REACT_90118
Reactome:REACT_91045
Reactome:REACT_98572
molecular_function
GO:0016787
hydrolase activity
Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
ISBN:0198506732
Reactome:REACT_110436
Hydrolysis of phosphatidylcholine, Bos taurus
Reactome:REACT_111159
Partial proteolysis of antigen in phagolysosomes, Homo sapiens
Reactome:REACT_15331
Hydrolysis of phosphatidylcholine, Homo sapiens
Reactome:REACT_83734
Hydrolysis of phosphatidylcholine, Danio rerio
Reactome:REACT_84047
Hydrolysis of phosphatidylcholine, Xenopus tropicalis
Reactome:REACT_87959
Hydrolysis of phosphatidylcholine, Gallus gallus
Reactome:REACT_88159
Hydrolysis of phosphatidylcholine, Canis familiaris
Reactome:REACT_90118
Hydrolysis of phosphatidylcholine, Mus musculus
Reactome:REACT_91045
Hydrolysis of phosphatidylcholine, Taeniopygia guttata
Reactome:REACT_98572
Hydrolysis of phosphatidylcholine, Rattus norvegicus
Catalysis of the hydrolysis of any ester bond.
EC:3.1
Reactome:REACT_106563
Reactome:REACT_109748
Reactome:REACT_112177
Reactome:REACT_19294
Reactome:REACT_1978
Reactome:REACT_45174
Reactome:REACT_77112
Reactome:REACT_81282
Reactome:REACT_83347
Reactome:REACT_88228
Reactome:REACT_88314
Reactome:REACT_89615
Reactome:REACT_92446
Reactome:REACT_94475
esterase activity
molecular_function
GO:0016788
hydrolase activity, acting on ester bonds
Catalysis of the hydrolysis of any ester bond.
GOC:jl
Reactome:REACT_106563
Deacylation of Acyl Ghrelin, Mus musculus
Reactome:REACT_109748
Deacylation of Acyl Ghrelin, Bos taurus
Reactome:REACT_112177
uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Xenopus tropicalis
Reactome:REACT_19294
Deacylation of Acyl Ghrelin, Homo sapiens
Reactome:REACT_1978
uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Homo sapiens
Reactome:REACT_45174
uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Mus musculus
Reactome:REACT_77112
uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Danio rerio
Reactome:REACT_81282
Deacylation of Acyl Ghrelin, Rattus norvegicus
Reactome:REACT_83347
Deacylation of Acyl Ghrelin, Gallus gallus
Reactome:REACT_88228
Deacylation of Acyl Ghrelin, Canis familiaris
Reactome:REACT_88314
uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Sus scrofa
Reactome:REACT_89615
uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Rattus norvegicus
Reactome:REACT_92446
uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Canis familiaris
Reactome:REACT_94475
uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Bos taurus
The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event.
protein uptake
biological_process
GO:0017038
protein import
The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event.
GOC:ai
The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
heterocycle anabolism
heterocycle biosynthesis
heterocycle formation
heterocycle synthesis
biological_process
GO:0018130
heterocycle biosynthetic process
The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
ISBN:0198547684
Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
biological_process
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GO:0019219
regulation of nucleobase-containing compound metabolic process
Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
GOC:go_curators
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GOC:dph
GOC:tb
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
regulation of metabolism
biological_process
GO:0019222
regulation of metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GOC:go_curators
The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring.
aromatic compound anabolism
aromatic compound biosynthesis
aromatic compound formation
aromatic compound synthesis
aromatic hydrocarbon biosynthesis
aromatic hydrocarbon biosynthetic process
biological_process
GO:0019438
aromatic compound biosynthetic process
The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring.
GOC:ai
The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.
aromatic compound breakdown
aromatic compound catabolism
aromatic compound degradation
aromatic hydrocarbon catabolic process
aromatic hydrocarbon catabolism
biological_process
GO:0019439
aromatic compound catabolic process
The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.
GOC:ai
The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.
biological_process
GO:0022402
cell cycle process
The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.
GOC:isa_complete
GOC:mtg_cell_cycle
One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
biological_process
GO:0022403
cell cycle phase
One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
GOC:mtg_cell_cycle
A cellular process that results in the breakdown of a cellular component.
GO:0071845
cell structure disassembly
cellular component disassembly at cellular level
biological_process
GO:0022411
cellular component disassembly
A cellular process that results in the breakdown of a cellular component.
GOC:isa_complete
The aggregation, arrangement and bonding together of a cellular component.
GO:0071844
cell structure assembly
cellular component assembly at cellular level
biological_process
GO:0022607
cellular component assembly
The aggregation, arrangement and bonding together of a cellular component.
GOC:isa_complete
The attachment of a cell or organism to a substrate or other organism.
biological_process
GO:0022610
biological adhesion
The attachment of a cell or organism to a substrate or other organism.
GOC:isa_complete
Any process that modulates the frequency, rate or extent of a signaling process.
2010-02-16T09:30:50Z
biological_process
regulation of signaling process
regulation of signalling process
GO:0023051
regulation of signaling
Any process that modulates the frequency, rate or extent of a signaling process.
GOC:mtg_signal
regulation of signaling process
GOC:bf
regulation of signalling process
GOC:mah
The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
2010-02-16T09:30:50Z
GO:0023046
biological signaling
signaling process
signalling
biological_process
signalling process
GO:0023052
Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change.
signaling
The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
GOC:mtg_signal
GOC:mtg_signaling_feb11
GOC:signaling
signalling process
GOC:mah
Any process that activates, maintains or increases the frequency, rate or extent of a signaling process.
2010-02-16T09:30:50Z
positive regulation of signalling process
biological_process
positive regulation of signaling process
GO:0023056
positive regulation of signaling
Any process that activates, maintains or increases the frequency, rate or extent of a signaling process.
GOC:mtg_signal
positive regulation of signalling process
GOC:mah
positive regulation of signaling process
GOC:bf
Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.
2010-02-16T09:30:50Z
biological_process
negative regulation of signaling process
negative regulation of signalling process
GO:0023057
negative regulation of signaling
Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.
GOC:mtg_signal
negative regulation of signaling process
GOC:bf
negative regulation of signalling process
GOC:mah
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
Wikipedia:Lamellipodia
cellular_component
GO:0030027
lamellipodium
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
ISBN:0815316194
Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.
biological_process
microfilament-based process
GO:0030029
actin filament-based process
Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.
GOC:mah
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
cell projection organisation
biological_process
cell projection organization and biogenesis
cell surface structure organization and biogenesis
GO:0030030
cell projection organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
GOC:jl
GOC:mah
http://www.cogsci.princeton.edu/~wn/
cell projection organisation
GOC:curators
cell projection organization and biogenesis
GOC:mah
cell surface structure organization and biogenesis
GOC:mah
Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.
formation of a cell surface projection
biological_process
cell projection biogenesis
GO:0030031
cell projection assembly
Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.
GOC:jl
GOC:mah
http://www.cogsci.princeton.edu/~wn/
cell projection biogenesis
GOC:mah
Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.
biological_process
GO:0030048
actin filament-based movement
Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.
GOC:BHF
GOC:mah
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
Wikipedia:Cell_junction
cellular_component
GO:0030054
cell junction
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
GOC:mah
ISBN:0198506732
http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html
A cell junction that forms a connection between a cell and the extracellular matrix.
cell-matrix junction
cellular_component
GO:0030055
cell-substrate junction
A cell junction that forms a connection between a cell and the extracellular matrix.
GOC:hb
GOC:mah
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
NIF_Subcellular:sao1362520468
endocytotic transport vesicle
endocytotic vesicle
cellular_component
GO:0030139
endocytic vesicle
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
GOC:go_curators
PMID:19696797
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
Wikipedia:Cellular_differentiation
biological_process
GO:0030154
cell differentiation
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
ISBN:0198506732
Thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
GO:0030028
NIF_Subcellular:sao-1046371754
Wikipedia:Filopodia
cellular_component
GO:0030175
A filopodium may be approximately 0.1 um wide, 5-10 um long, and up to 50 um long in axon growth cones; may contain a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward. Note that filopodia on dendritic shafts are distinct from other types of filopodia (even those found in dendritic growth cones) and may react differently to stimuli, as shown in PMID:12904473.
filopodium
Thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
GOC:mah
GOC:pr
ISBN:0815316194
The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.
GO:0000068
DNA condensation
eukaryotic chromosome condensation
nuclear chromosome condensation
biological_process
GO:0030261
chromosome condensation
The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.
GOC:mah
ISBN:0815316194
DNA condensation
Wikipedia:DNA_condensation
eukaryotic chromosome condensation
GOC:bf
nuclear chromosome condensation
GOC:bf
Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis.
apoptotic nuclear change
biological_process
GO:0030262
apoptotic nuclear changes
Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis.
GOC:mah
GOC:mtg_apoptosis
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
NIF_Subcellular:sao1770195789
Wikipedia:Axon
cellular_component
GO:0030424
axon
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
GOC:nln
ISBN:0198506732
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
NIF_Subcellular:sao1211023249
Wikipedia:Dendrite
cellular_component
GO:0030425
dendrite
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
GOC:dos
GOC:mah
GOC:nln
ISBN:0198506732
The portion of the cytoskeleton that lies just beneath the plasma membrane.
cellular_component
GO:0030863
cortical cytoskeleton
The portion of the cytoskeleton that lies just beneath the plasma membrane.
GOC:mah
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
cellular_component
GO:0030864
cortical actin cytoskeleton
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
GOC:mah
A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules.
intraflagellar transport complex
intraflagellar transport particle
cellular_component
IFT complex
GO:0030990
Note that we deem cilia and microtubule-based flagella to be equivalent.
intraciliary transport particle
A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules.
GOC:cilia
GOC:kmv
PMID:14570576
PMID:22118932
PMID:23945166
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow.
microtubule organising center organisation
biological_process
microtubule organizing center organization and biogenesis
GO:0031023
microtubule organizing center organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow.
GOC:dph
GOC:jl
GOC:mah
microtubule organising center organisation
GOC:curators
microtubule organizing center organization and biogenesis
GOC:mah
A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell.
Wikipedia:Micronucleus
cellular_component
GO:0031040
micronucleus
A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell.
GOC:ns
The area of a motile cell closest to the direction of movement.
front of cell
leading edge of cell
cellular_component
GO:0031252
cell leading edge
The area of a motile cell closest to the direction of movement.
GOC:pg
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
regulation of cellular metabolism
biological_process
GO:0031323
regulation of cellular metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
GOC:mah
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
down regulation of cellular metabolic process
down-regulation of cellular metabolic process
downregulation of cellular metabolic process
negative regulation of cellular metabolism
inhibition of cellular metabolic process
biological_process
GO:0031324
negative regulation of cellular metabolic process
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
GOC:mah
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
Reactome:REACT_101225
Reactome:REACT_102187
Reactome:REACT_102331
Reactome:REACT_105293
Reactome:REACT_108571
Reactome:REACT_109170
Reactome:REACT_2122
Reactome:REACT_28360
Reactome:REACT_31270
Reactome:REACT_79603
Reactome:REACT_80902
Reactome:REACT_83058
Reactome:REACT_84314
Reactome:REACT_86633
Reactome:REACT_87840
Reactome:REACT_88060
Reactome:REACT_91293
Reactome:REACT_91429
Reactome:REACT_91906
Reactome:REACT_92487
Reactome:REACT_99393
positive regulation of cellular metabolism
up regulation of cellular metabolic process
up-regulation of cellular metabolic process
upregulation of cellular metabolic process
activation of cellular metabolic process
stimulation of cellular metabolic process
biological_process
GO:0031325
positive regulation of cellular metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
GOC:mah
Reactome:REACT_101225
ChREBP activates metabolic gene expression, Mus musculus
Reactome:REACT_102187
ChREBP activates metabolic gene expression, Escherichia coli
Reactome:REACT_102331
ChREBP activates metabolic gene expression, Caenorhabditis elegans
Reactome:REACT_105293
ChREBP activates metabolic gene expression, Plasmodium falciparum
Reactome:REACT_108571
ChREBP activates metabolic gene expression, Drosophila melanogaster
Reactome:REACT_109170
ChREBP activates metabolic gene expression, Xenopus tropicalis
Reactome:REACT_2122
ChREBP activates metabolic gene expression, Homo sapiens
Reactome:REACT_28360
ChREBP activates metabolic gene expression, Arabidopsis thaliana
Reactome:REACT_31270
ChREBP activates metabolic gene expression, Mycobacterium tuberculosis
Reactome:REACT_79603
ChREBP activates metabolic gene expression, Canis familiaris
Reactome:REACT_80902
ChREBP activates metabolic gene expression, Saccharomyces cerevisiae
Reactome:REACT_83058
ChREBP activates metabolic gene expression, Taeniopygia guttata
Reactome:REACT_84314
ChREBP activates metabolic gene expression, Oryza sativa
Reactome:REACT_86633
ChREBP activates metabolic gene expression, Dictyostelium discoideum
Reactome:REACT_87840
ChREBP activates metabolic gene expression, Danio rerio
Reactome:REACT_88060
ChREBP activates metabolic gene expression, Rattus norvegicus
Reactome:REACT_91293
ChREBP activates metabolic gene expression, Staphylococcus aureus N315
Reactome:REACT_91429
ChREBP activates metabolic gene expression, Gallus gallus
Reactome:REACT_91906
ChREBP activates metabolic gene expression, Schizosaccharomyces pombe
Reactome:REACT_92487
ChREBP activates metabolic gene expression, Bos taurus
Reactome:REACT_99393
ChREBP activates metabolic gene expression, Sus scrofa
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
regulation of cellular anabolism
regulation of cellular biosynthesis
regulation of cellular formation
regulation of cellular synthesis
biological_process
GO:0031326
regulation of cellular biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
GOC:mah
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
down regulation of cellular biosynthetic process
down-regulation of cellular biosynthetic process
downregulation of cellular biosynthetic process
negative regulation of cellular anabolism
negative regulation of cellular biosynthesis
negative regulation of cellular formation
negative regulation of cellular synthesis
inhibition of cellular biosynthetic process
biological_process
GO:0031327
negative regulation of cellular biosynthetic process
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
GOC:mah
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
positive regulation of cellular anabolism
positive regulation of cellular biosynthesis
positive regulation of cellular formation
positive regulation of cellular synthesis
up regulation of cellular biosynthetic process
up-regulation of cellular biosynthetic process
upregulation of cellular biosynthetic process
activation of cellular biosynthetic process
stimulation of cellular biosynthetic process
biological_process
GO:0031328
positive regulation of cellular biosynthetic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
GOC:mah
A vesicle formed of membrane or protein, found in the cytoplasm of a cell.
NIF_Subcellular:sao180601769
cellular_component
GO:0031410
cytoplasmic vesicle
A vesicle formed of membrane or protein, found in the cytoplasm of a cell.
GOC:mah
A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location.
establishment and maintenance of protein complex localization
protein complex localisation
biological_process
GO:0031503
protein complex localization
A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location.
GOC:mah
protein complex localisation
GOC:mah
A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure.
Polycomb Group protein complex
cellular_component
GO:0031519
PcG protein complex
A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure.
PMID:9372908
The attachment of a cell to the underlying substrate via adhesion molecules.
biological_process
GO:0031589
cell-substrate adhesion
The attachment of a cell to the underlying substrate via adhesion molecules.
GOC:mah
GOC:pf
The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.
cellular_component
GO:0031974
membrane-enclosed lumen
The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.
GOC:add
GOC:mah
The volume enclosed by the nuclear inner membrane.
cellular_component
GO:0031981
nuclear lumen
The volume enclosed by the nuclear inner membrane.
GOC:mah
GOC:pz
Any small, fluid-filled, spherical organelle enclosed by membrane or protein.
NIF_Subcellular:sao221389602
Wikipedia:Vesicle_(biology)
cellular_component
GO:0031982
vesicle
Any small, fluid-filled, spherical organelle enclosed by membrane or protein.
GOC:mah
GOC:pz
Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer.
membrane-enclosed vesicle
cellular_component
GO:0031988
membrane-bounded vesicle
Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer.
GOC:mah
The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.
blebbing
membrane blebbing
cell blebbing
plasma membrane bleb assembly
plasma membrane blebbing
biological_process
GO:0032060
bleb assembly
The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.
GOC:mah
GOC:mtg_apoptosis
PMID:12083798
PMID:16624291
http://en.wikipedia.org/wiki/Bleb_(cell_biology)
blebbing
GOC:pr
membrane blebbing
GOC:pr
plasma membrane bleb assembly
GOC:pr
plasma membrane blebbing
GOC:pr
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
inhibition of NF-kappaB transcription factor
biological_process
NF-kappaB inhibitor
GO:0032088
negative regulation of NF-kappaB transcription factor activity
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
GOC:dph
GOC:rl
GOC:tb
inhibition of NF-kappaB transcription factor
GOC:dph
GOC:tb
Any process that modulates the frequency, rate or extent of the directed movement of substances within cells.
biological_process
GO:0032386
regulation of intracellular transport
Any process that modulates the frequency, rate or extent of the directed movement of substances within cells.
GOC:mah
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells.
down regulation of intracellular transport
down-regulation of intracellular transport
downregulation of intracellular transport
inhibition of intracellular transport
biological_process
GO:0032387
negative regulation of intracellular transport
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells.
GOC:mah
Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells.
up regulation of intracellular transport
up-regulation of intracellular transport
upregulation of intracellular transport
activation of intracellular transport
stimulation of intracellular transport
biological_process
GO:0032388
positive regulation of intracellular transport
Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells.
GOC:mah
An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
GO:0000141
GO:0030482
cellular_component
actin cable
GO:0032432
actin filament bundle
An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
GOC:mah
actin cable
GOC:mah
A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
development
biological_process
GO:0032502
developmental process
A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
GOC:isa_complete
Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.
biological_process
maintenance of protein localization in cell
GO:0032507
maintenance of protein location in cell
Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.
GOC:isa_complete
GOC:mah
maintenance of protein localization in cell
GOC:dph
GOC:tb
The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication.
RNA anabolism
RNA biosynthesis
RNA formation
RNA synthesis
biological_process
GO:0032774
Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study.
RNA biosynthetic process
The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication.
GOC:mah
GOC:txnOH
Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.
regulation of localisation
biological_process
GO:0032879
regulation of localization
Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.
GOC:mah
regulation of localisation
GOC:mah
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
regulation of protein localisation
biological_process
GO:0032880
regulation of protein localization
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
GOC:dph
GOC:mah
GOC:tb
regulation of protein localisation
GOC:mah
The controlled release of a substance by a cell.
Wikipedia:Secretion
cellular secretion
biological_process
GO:0032940
secretion by cell
The controlled release of a substance by a cell.
GOC:mah
The process in which cellular structures, including whole cells or cell parts, are generated and organized.
cellular structure morphogenesis
biological_process
GO:0032989
cellular component morphogenesis
The process in which cellular structures, including whole cells or cell parts, are generated and organized.
GOC:dph
GOC:mah
GOC:tb
cellular structure morphogenesis
GOC:dph
GOC:tb
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
macromolecule complex
cellular_component
GO:0032991
macromolecular complex
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
GOC:mah
Any process in which a macromolecule is transported to, or maintained in, a specific location.
macromolecule localisation
biological_process
GO:0033036
macromolecule localization
Any process in which a macromolecule is transported to, or maintained in, a specific location.
GOC:mah
macromolecule localisation
GOC:mah
Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells.
biological_process
GO:0033157
regulation of intracellular protein transport
Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells.
GOC:mah
A process in which a protein is transported to, or maintained in, a location within an organelle.
protein localisation to organelle
protein localization in organelle
biological_process
GO:0033365
protein localization to organelle
A process in which a protein is transported to, or maintained in, a location within an organelle.
GOC:mah
protein localisation to organelle
GOC:mah
protein localization in organelle
GOC:mah
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
biological_process
GO:0033554
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
cellular response to stress
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
GOC:mah
Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group.
Reactome:REACT_115680
Reactome:REACT_115778
Reactome:REACT_115899
Reactome:REACT_115932
Reactome:REACT_116106
Reactome:REACT_116167
DNA nucleotidyltransferase activity
deoxynucleate polymerase activity
deoxyribonucleate nucleotidyltransferase activity
deoxyribonucleic acid polymerase activity
deoxyribonucleic polymerase activity
molecular_function
GO:0034061
DNA polymerase activity
Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group.
EC:2.7.7.7
GOC:mah
Reactome:REACT_115680
Insertion of correct bases opposite to the lesion by Pol kappa, Gallus gallus
Reactome:REACT_115778
Elongation by Pol zeta complex, Gallus gallus
Reactome:REACT_115899
Elongation by Pol kappa, Gallus gallus
Reactome:REACT_115932
Insertion of correct bases opposite to the lesion by Pol eta, Gallus gallus
Reactome:REACT_116106
Repair of ~27-30 bp long patch by DNA Pol Epsilon, Gallus gallus
Reactome:REACT_116167
Elongation by Pol eta, Gallus gallus
DNA nucleotidyltransferase activity
EC:2.7.7.7
deoxynucleate polymerase activity
EC:2.7.7.7
deoxyribonucleate nucleotidyltransferase activity
EC:2.7.7.7
deoxyribonucleic acid polymerase activity
EC:2.7.7.7
deoxyribonucleic polymerase activity
EC:2.7.7.7
A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus.
protein localisation in Golgi apparatus
protein localization in Golgi apparatus
biological_process
GO:0034067
protein localization to Golgi apparatus
A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus.
GOC:mah
protein localisation in Golgi apparatus
GOC:mah
protein localization in Golgi apparatus
GOC:curators
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
cell spreading during cell substrate adhesion
substrate adhesion dependent cell spreading
biological_process
GO:0034446
substrate adhesion-dependent cell spreading
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
GOC:mah
GOC:pf
PMID:17050732
A process in which a protein is transported to, or maintained in, a location within the nucleus.
protein localisation to nucleus
protein localization in cell nucleus
protein localization in nucleus
biological_process
GO:0034504
protein localization to nucleus
A process in which a protein is transported to, or maintained in, a location within the nucleus.
GOC:ecd
protein localisation to nucleus
GOC:mah
protein localization in nucleus
GOC:mah
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
GO:0016249
cellular protein localisation
channel localizer activity
biological_process
GO:0034613
cellular protein localization
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
GOC:mah
cellular protein localisation
GOC:mah
channel localizer activity
GOC:mah
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
Reactome:REACT_102000
Reactome:REACT_103710
Reactome:REACT_107293
Reactome:REACT_108179
Reactome:REACT_109042
Reactome:REACT_13
Reactome:REACT_28699
Reactome:REACT_29108
Reactome:REACT_32429
Reactome:REACT_33347
Reactome:REACT_34326
Reactome:REACT_55564
Reactome:REACT_77741
Reactome:REACT_82379
Reactome:REACT_86268
Reactome:REACT_90299
Reactome:REACT_91959
Reactome:REACT_93580
Reactome:REACT_95666
Reactome:REACT_98086
Reactome:REACT_99241
cellular nitrogen compound metabolism
biological_process
GO:0034641
cellular nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
GOC:mah
Reactome:REACT_102000
Metabolism of amino acids and derivatives, Mycobacterium tuberculosis
Reactome:REACT_103710
Metabolism of amino acids and derivatives, Escherichia coli
Reactome:REACT_107293
Metabolism of amino acids and derivatives, Arabidopsis thaliana
Reactome:REACT_108179
Metabolism of amino acids and derivatives, Xenopus tropicalis
Reactome:REACT_109042
Metabolism of amino acids and derivatives, Sus scrofa
Reactome:REACT_13
Metabolism of amino acids and derivatives, Homo sapiens
Reactome:REACT_28699
Metabolism of amino acids and derivatives, Saccharomyces cerevisiae
Reactome:REACT_29108
Metabolism of amino acids and derivatives, Caenorhabditis elegans
Reactome:REACT_32429
Metabolism of amino acids and derivatives, Rattus norvegicus
Reactome:REACT_33347
Metabolism of amino acids and derivatives, Mus musculus
Reactome:REACT_34326
Metabolism of amino acids and derivatives, Staphylococcus aureus N315
Reactome:REACT_55564
Metabolism of amino acids and derivatives, Gallus gallus
Reactome:REACT_77741
Metabolism of amino acids and derivatives, Taeniopygia guttata
Reactome:REACT_82379
Metabolism of amino acids and derivatives, Bos taurus
Reactome:REACT_86268
Metabolism of amino acids and derivatives, Drosophila melanogaster
Reactome:REACT_90299
Metabolism of amino acids and derivatives, Oryza sativa
Reactome:REACT_91959
Metabolism of amino acids and derivatives, Plasmodium falciparum
Reactome:REACT_93580
Metabolism of amino acids and derivatives, Danio rerio
Reactome:REACT_95666
Metabolism of amino acids and derivatives, Canis familiaris
Reactome:REACT_98086
Metabolism of amino acids and derivatives, Dictyostelium discoideum
Reactome:REACT_99241
Metabolism of amino acids and derivatives, Schizosaccharomyces pombe
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.
GO:0034961
cellular biopolymer biosynthetic process
cellular macromolecule anabolism
cellular macromolecule biosynthesis
cellular macromolecule formation
cellular macromolecule synthesis
biological_process
GO:0034645
cellular macromolecule biosynthetic process
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.
CHEBI:33694
GOC:mah
cellular biopolymer biosynthetic process
GOC:mtg_chebi_dec09
cellular macromolecule anabolism
GOC:mah
cellular macromolecule biosynthesis
GOC:mah
cellular macromolecule formation
GOC:mah
cellular macromolecule synthesis
GOC:mah
The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids.
nucleobase, nucleoside, nucleotide and nucleic acid anabolism
nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis
nucleobase, nucleoside, nucleotide and nucleic acid formation
nucleobase, nucleoside, nucleotide and nucleic acid synthesis
biological_process
GO:0034654
nucleobase-containing compound biosynthetic process
The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids.
GOC:mah
The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids.
nucleobase, nucleoside, nucleotide and nucleic acid breakdown
nucleobase, nucleoside, nucleotide and nucleic acid catabolism
nucleobase, nucleoside, nucleotide and nucleic acid degradation
biological_process
nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
GO:0034655
nucleobase-containing compound catabolic process
The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids.
GOC:mah
nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
GOC:dph
GOC:tb
A process in which a protein is transported to, or maintained at, a microtubule.
rfoulger
2010-03-11T11:00:56Z
protein localisation to microtubule
biological_process
GO:0035372
protein localization to microtubule
A process in which a protein is transported to, or maintained at, a microtubule.
GOC:bf
GOC:lb
protein localisation to microtubule
GOC:mah
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
rfoulger
2010-05-14T01:14:37Z
GO:0007242
GO:0007243
GO:0023013
GO:0023034
Reactome:REACT_100795
Reactome:REACT_102462
Reactome:REACT_104200
Reactome:REACT_108216
Reactome:REACT_1525
Reactome:REACT_80030
Reactome:REACT_83068
Reactome:REACT_83869
Reactome:REACT_87453
Reactome:REACT_89085
Reactome:REACT_89983
Reactome:REACT_90740
Reactome:REACT_99938
intracellular signaling chain
intracellular protein kinase cascade
intracellular signal transduction pathway
protein kinase cascade
signal transmission via intracellular cascade
biological_process
intracellular signaling cascade
intracellular signaling pathway
signal transduction via intracellular signaling cascade
GO:0035556
intracellular signal transduction
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
GOC:bf
GOC:jl
GOC:signaling
ISBN:3527303782
Reactome:REACT_100795
PKA-mediated phosphorylation of key metabolic factors, Saccharomyces cerevisiae
Reactome:REACT_102462
PKA-mediated phosphorylation of key metabolic factors, Canis familiaris
Reactome:REACT_104200
PKA-mediated phosphorylation of key metabolic factors, Taeniopygia guttata
Reactome:REACT_108216
PKA-mediated phosphorylation of key metabolic factors, Dictyostelium discoideum
Reactome:REACT_1525
PKA-mediated phosphorylation of key metabolic factors, Homo sapiens
Reactome:REACT_80030
PKA-mediated phosphorylation of key metabolic factors, Sus scrofa
Reactome:REACT_83068
PKA-mediated phosphorylation of key metabolic factors, Gallus gallus
Reactome:REACT_83869
PKA-mediated phosphorylation of key metabolic factors, Xenopus tropicalis
Reactome:REACT_87453
PKA-mediated phosphorylation of key metabolic factors, Bos taurus
Reactome:REACT_89085
PKA-mediated phosphorylation of key metabolic factors, Rattus norvegicus
Reactome:REACT_89983
PKA-mediated phosphorylation of key metabolic factors, Danio rerio
Reactome:REACT_90740
PKA-mediated phosphorylation of key metabolic factors, Schizosaccharomyces pombe
Reactome:REACT_99938
PKA-mediated phosphorylation of key metabolic factors, Mus musculus
intracellular signaling chain
ISBN:3527303782
intracellular protein kinase cascade
GOC:signaling
protein kinase cascade
GOC:signaling
intracellular signaling cascade
GOC:signaling
A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
rfoulger
2011-05-17T03:04:42Z
site of DSB
cellular_component
DNA damage foci
DNA damage focus
IRIF
ionizing radiation-induced foci
GO:0035861
site of double-strand break
A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
GOC:bf
GOC:mah
GOC:vw
PMID:20096808
PMID:21035408
site of DSB
PMID:21035408
DNA damage foci
GOC:vw
DNA damage focus
GOC:mah
PMID:20096808
PMID:21035408
IRIF
PMID:20096808
PMID:21035408
ionizing radiation-induced foci
PMID:20096808
PMID:21035408
The region of a neuron that includes the cell body (cell soma) and the dendrite, but excludes the axon.
rebeccafoulger
2014-07-24T10:06:19Z
cellular_component
GO:0036477
somatodendritic compartment
The region of a neuron that includes the cell body (cell soma) and the dendrite, but excludes the axon.
GOC:PARL
GOC:pad
The increase in size or mass of an entire organism, a part of an organism or a cell.
GO:0048590
biological_process
growth pattern
non-developmental growth
GO:0040007
See also the biological process term 'cell growth ; GO:0016049'.
growth
The increase in size or mass of an entire organism, a part of an organism or a cell.
GOC:bf
GOC:ma
non-developmental growth
GOC:mah
Self-propelled movement of a cell or organism from one location to another.
biological_process
GO:0040011
locomotion
Self-propelled movement of a cell or organism from one location to another.
GOC:dgh
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
response to chemical stimulus
response to chemical substance
biological_process
GO:0042221
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
response to chemical
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
GOC:jl
response to chemical stimulus
GOC:dos
Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus.
regulation of protein import into cell nucleus
regulation of protein transport from cytoplasm to nucleus
regulation of protein-nucleus import
biological_process
GO:0042306
regulation of protein import into nucleus
Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus.
GOC:jl
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
positive regulation of protein import into cell nucleus
positive regulation of protein transport from cytoplasm to nucleus
positive regulation of protein-nucleus import
up regulation of protein import into nucleus
up-regulation of protein import into nucleus
upregulation of protein import into nucleus
activation of protein import into nucleus
stimulation of protein import into nucleus
biological_process
GO:0042307
positive regulation of protein import into nucleus
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
GOC:jl
Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.
down regulation of protein import into nucleus
down-regulation of protein import into nucleus
downregulation of protein import into nucleus
negative regulation of protein import into cell nucleus
negative regulation of protein transport from cytoplasm to nucleus
negative regulation of protein-nucleus import
inhibition of protein import into nucleus
biological_process
GO:0042308
negative regulation of protein import into nucleus
Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.
GOC:jl
Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.
regulation of NF-kappaB import into cell nucleus
regulation of NF-kappaB transport from cytoplasm to nucleus
regulation of NF-kappaB-nucleus import
biological_process
GO:0042345
regulation of NF-kappaB import into nucleus
Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.
GOC:jl
ISBN:0198506732
Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.
positive regulation of NF-kappaB import into cell nucleus
positive regulation of NF-kappaB transport from cytoplasm to nucleus
positive regulation of NF-kappaB-nucleus import
up regulation of NF-kappaB import into nucleus
up-regulation of NF-kappaB import into nucleus
upregulation of NF-kappaB import into nucleus
activation of NF-kappaB import into nucleus
stimulation of NF-kappaB import into nucleus
biological_process
GO:0042346
positive regulation of NF-kappaB import into nucleus
Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.
GOC:jl
ISBN:0198506732
Any process that stops, prevents, or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.
down regulation of NF-kappaB import into nucleus
down-regulation of NF-kappaB import into nucleus
downregulation of NF-kappaB import into nucleus
negative regulation of NF-kappaB import into cell nucleus
negative regulation of NF-kappaB transport from cytoplasm to nucleus
negative regulation of NF-kappaB-nucleus import
inhibition of NF-kappaB import into nucleus
biological_process
GO:0042347
negative regulation of NF-kappaB import into nucleus
Any process that stops, prevents, or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.
GOC:jl
ISBN:0198506732
The directed movement of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.
NF-KB import into nucleus
NF-kappaB import into cell nucleus
NF-kappaB protein-nucleus import
NF-kappaB transport from cytoplasm to nucleus
NF-kappaB-nucleus import
biological_process
GO:0042348
NF-kappaB import into nucleus
The directed movement of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.
GOC:jl
ISBN:0198506732
NF-KB import into nucleus
GOC:bf
Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei.
Wikipedia:Paraspeckle
cellular_component
GO:0042382
paraspeckles
Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei.
GOC:jl
PMID:11790299
Any complex of actin, myosin, and accessory proteins.
actomyosin complex
actomyosin structure
cellular_component
GO:0042641
actomyosin
Any complex of actin, myosin, and accessory proteins.
GOC:go_curators
Polarized growth from one end of a cell.
monopolar growth
monopolar cell elongation
polar cell elongation
biological_process
GO:0042814
monopolar cell growth
Polarized growth from one end of a cell.
GOC:vw
The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
biological_process
GO:0042886
amide transport
The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GOC:jl
ISBN:0198506732
Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.
regulation of transcription factor import into cell nucleus
regulation of transcription factor transport from cytoplasm to nucleus
regulation of transcription factor-nucleus import
biological_process
GO:0042990
regulation of transcription factor import into nucleus
Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.
GOC:jl
The directed movement of a transcription factor from the cytoplasm to the nucleus.
transcription factor import into cell nucleus
transcription factor transport from cytoplasm to nucleus
transcription factor-nucleus import
biological_process
GO:0042991
transcription factor import into nucleus
The directed movement of a transcription factor from the cytoplasm to the nucleus.
GOC:jl
Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.
down regulation of transcription factor import into nucleus
down-regulation of transcription factor import into nucleus
downregulation of transcription factor import into nucleus
negative regulation of transcription factor import into cell nucleus
negative regulation of transcription factor transport from cytoplasm to nucleus
negative regulation of transcription factor-nucleus import
inhibition of transcription factor import into nucleus
biological_process
GO:0042992
negative regulation of transcription factor import into nucleus
Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.
GOC:jl
Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.
positive regulation of transcription factor import into cell nucleus
positive regulation of transcription factor transport from cytoplasm to nucleus
positive regulation of transcription factor-nucleus import
up regulation of transcription factor import into nucleus
up-regulation of transcription factor import into nucleus
upregulation of transcription factor import into nucleus
activation of transcription factor import into nucleus
stimulation of transcription factor import into nucleus
biological_process
GO:0042993
positive regulation of transcription factor import into nucleus
Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.
GOC:jl
The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.
cytoplasmic retention of transcription factor
cytoplasmic sequestration of transcription factor
cytoplasmic storage of transcription factor
maintenance of transcription factor protein location in cytoplasm
retention of transcription factor in cytoplasm
sequestering of transcription factor in cytoplasm
sequestration of transcription factor in cytoplasm
storage of transcription factor in cytoplasm
transcription factor binding, cytoplasmic sequestering
biological_process
GO:0042994
cytoplasmic sequestering of transcription factor
The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.
GOC:jl
maintenance of transcription factor protein location in cytoplasm
GOC:dph
GOC:tb
A prolongation or process extending from a cell, e.g. a flagellum or axon.
cell process
cellular process
cellular projection
cellular_component
GO:0042995
cell projection
A prolongation or process extending from a cell, e.g. a flagellum or axon.
GOC:jl
http://www.cogsci.princeton.edu/~wn/
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
NIF_Subcellular:sao-867568886
neuron process
neuron protrusion
neuronal cell projection
neurite
cellular_component
GO:0043005
neuron projection
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
GOC:jl
http://www.cogsci.princeton.edu/~wn/
neuron protrusion
NIF_Subcellular:sao-250931889
Any process that modulates I-kappaB kinase/NF-kappaB signaling.
biological_process
regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043122
regulation of I-kappaB kinase/NF-kappaB signaling
Any process that modulates I-kappaB kinase/NF-kappaB signaling.
GOC:jl
PMID:12773372
regulation of I-kappaB kinase/NF-kappaB cascade
GOC:signaling
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
Reactome:REACT_24918
stimulation of I-kappaB kinase/NF-kappaB cascade
biological_process
activation of I-kappaB kinase/NF-kappaB cascade
positive regulation of I-kappaB kinase/NF-kappaB cascade
up regulation of I-kappaB kinase/NF-kappaB cascade
up-regulation of I-kappaB kinase/NF-kappaB cascade
upregulation of I-kappaB kinase/NF-kappaB cascade
GO:0043123
positive regulation of I-kappaB kinase/NF-kappaB signaling
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
GOC:jl
Reactome:REACT_24918
IRAK1 recruits IKK complex, Homo sapiens
positive regulation of I-kappaB kinase/NF-kappaB cascade
GOC:signaling
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
inhibition of I-kappaB kinase/NF-kappaB cascade
biological_process
down regulation of I-kappaB kinase/NF-kappaB cascade
down-regulation of I-kappaB kinase/NF-kappaB cascade
downregulation of I-kappaB kinase/NF-kappaB cascade
negative regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043124
negative regulation of I-kappaB kinase/NF-kappaB signaling
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
GOC:jl
negative regulation of I-kappaB kinase/NF-kappaB cascade
GOC:signaling
The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
GO:0043283
biopolymer metabolic process
macromolecule metabolism
biological_process
GO:0043170
macromolecule metabolic process
The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
CHEBI:33694
GOC:mah
biopolymer metabolic process
GOC:mtg_chebi_dec09
Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
NIF_Subcellular:sao1539965131
Wikipedia:Organelle
cellular_component
GO:0043226
organelle
Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
GOC:go_curators
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
NIF_Subcellular:sao414196390
membrane-enclosed organelle
cellular_component
GO:0043227
membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
GOC:go_curators
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
NIF_Subcellular:sao1456184038
non-membrane-enclosed organelle
cellular_component
GO:0043228
non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
GOC:go_curators
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
cellular_component
GO:0043229
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
GOC:go_curators
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular membrane-enclosed organelle
cellular_component
GO:0043231
intracellular membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
GOC:go_curators
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
intracellular non-membrane-enclosed organelle
cellular_component
GO:0043232
intracellular non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
GOC:go_curators
The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
cellular_component
GO:0043233
organelle lumen
The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
GOC:jl
GOC:mah
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
Wikipedia:Protein_complex
protein-protein complex
cellular_component
GO:0043234
A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole.
protein complex
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
GOC:go_curators
http://www.ebi.ac.uk/intact/complex/documentation/
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
negative regulation of transcription factor activity
down regulation of transcription factor activity
down-regulation of transcription factor activity
downregulation of transcription factor activity
inhibition of transcription factor activity
biological_process
GO:0043433
negative regulation of sequence-specific DNA binding transcription factor activity
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
GOC:jl
negative regulation of transcription factor activity
GOC:dph
GOC:tb
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
sequence specific DNA binding
molecular_function
GO:0043565
sequence-specific DNA binding
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
GOC:jl
A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component.
GO:0071843
cellular component biogenesis at cellular level
biological_process
GO:0044085
cellular component biogenesis
A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component.
GOC:jl
GOC:mah
Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
jane
2009-04-21T04:07:27Z
biological_process
GO:0044092
negative regulation of molecular function
Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
GO:jl
Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
jane
2009-04-21T04:11:06Z
biological_process
GO:0044093
positive regulation of molecular function
Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
GO:jl
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
jane
2009-11-04T12:58:25Z
molecular_function
GO:0044212
The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
transcription regulatory region DNA binding
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
GOC:jl
GOC:txnOH
SO:0005836
The chemical reactions and pathways by which individual cells transform chemical substances.
cellular metabolism
biological_process
intermediary metabolism
GO:0044237
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
GOC:go_curators
intermediary metabolism
GOC:mah
The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
primary metabolism
biological_process
GO:0044238
primary metabolic process
The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
GOC:go_curators
http://www.metacyc.org
The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
cellular breakdown
cellular catabolism
cellular degradation
biological_process
GO:0044248
cellular catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
GOC:jl
The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
cellular anabolism
cellular biosynthesis
cellular formation
cellular synthesis
biological_process
GO:0044249
cellular biosynthetic process
The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
GOC:jl
The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.
GO:0034960
cellular biopolymer metabolic process
cellular macromolecule metabolism
biological_process
GO:0044260
cellular macromolecule metabolic process
The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.
CHEBI:33694
GOC:mah
cellular biopolymer metabolic process
GOC:mtg_chebi_dec09
The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells.
GO:0034962
cellular biopolymer catabolic process
cellular macromolecule breakdown
cellular macromolecule catabolism
cellular macromolecule degradation
biological_process
GO:0044265
cellular macromolecule catabolic process
The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells.
CHEBI:33694
GOC:jl
cellular biopolymer catabolic process
GOC:mtg_chebi_dec09
The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds.
nitrogen compound breakdown
nitrogen compound catabolism
nitrogen compound degradation
biological_process
GO:0044270
cellular nitrogen compound catabolic process
The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds.
GOC:jl
ISBN:0198506732
The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.
nitrogen compound anabolism
nitrogen compound biosynthesis
nitrogen compound formation
nitrogen compound synthesis
biological_process
GO:0044271
cellular nitrogen compound biosynthetic process
The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.
GOC:jl
ISBN:0198506732
A dendrite arising from another dendrite.
jane
2010-02-05T04:18:53Z
NIF_Subcellular:sao884265541
dendrite branch
cellular_component
GO:0044307
dendritic branch
A dendrite arising from another dendrite.
NIF_Subcellular:sao884265541
A process in which a protein is transported to, or maintained in, a location within the cytoskeleton.
janelomax
2011-12-13T11:43:24Z
protein localisation to cytoskeleton
biological_process
GO:0044380
protein localization to cytoskeleton
A process in which a protein is transported to, or maintained in, a location within the cytoskeleton.
GOC:jl
protein localisation to cytoskeleton
GOC:mah
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
cellular_component
GO:0044422
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
GOC:jl
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
cellular_component
GO:0044424
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GOC:jl
Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
chromosomal component
chromosome component
chromosome part
cellular_component
GO:0044427
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
chromosomal part
Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
GOC:jl
Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.
NIF_Subcellular:sao1499850686
nuclear subcomponent
nucleus component
cellular_component
GO:0044428
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
nuclear part
Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.
GOC:jl
nuclear subcomponent
NIF_Subcellular:sao1499850686
Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
NIF_Subcellular:sao666410040
mitochondrial subcomponent
mitochondrion component
cellular_component
GO:0044429
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
mitochondrial part
Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
GOC:jl
mitochondrial subcomponent
NIF_Subcellular:sao666410040
Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.
NIF_Subcellular:sao1635329413
cytoskeletal element
cytoskeleton component
cellular_component
GO:0044430
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
cytoskeletal part
Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.
GOC:jl
cytoskeletal element
NIF_Subcellular:sao1635329413
Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack.
NIF_Subcellular:sao624292949
Golgi component
Golgi subcomponent
cellular_component
GO:0044431
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
Golgi apparatus part
Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack.
GOC:jl
Golgi subcomponent
NIF_Subcellular:sao624292949
Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
ER component
cellular_component
GO:0044432
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
endoplasmic reticulum part
Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
GOC:jl
Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasm component
cellular_component
GO:0044444
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
cytoplasmic part
Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GOC:jl
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
cellular_component
GO:0044446
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
GOC:jl
Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cellular_component
GO:0044448
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
cell cortex part
Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
GOC:jl
Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus.
cellular_component
GO:0044451
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
nucleoplasm part
Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus.
GOC:jl
Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.
cellular_component
GO:0044463
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
cell projection part
Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.
GOC:jl
Any constituent part of a cell, the basic structural and functional unit of all organisms.
NIF_Subcellular:sao628508602
cellular subcomponent
cellular_component
protoplast
GO:0044464
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
GOC:jl
cellular subcomponent
NIF_Subcellular:sao628508602
protoplast
GOC:mah
A biological process that involves only one organism.
janelomax
2012-09-19T15:05:24Z
single organism process
biological_process
GO:0044699
single-organism process
A biological process that involves only one organism.
GOC:jl
A signaling process occurring within a single organism.
janelomax
2012-09-19T15:12:49Z
biological_process
GO:0044700
single organism signaling
A signaling process occurring within a single organism.
GOC:jl
The process of directing proteins towards the nucleus, usually using signals contained within the protein.
janelomax
2012-11-07T15:45:54Z
biological_process
GO:0044744
protein targeting to nucleus
The process of directing proteins towards the nucleus, usually using signals contained within the protein.
GOC:jl
Any process that is carried out at the cellular level, occurring within a single organism.
janelomax
2012-12-11T16:56:55Z
biological_process
GO:0044763
single-organism cellular process
Any process that is carried out at the cellular level, occurring within a single organism.
GOC:jl
The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving a single organism.
janelomax
2012-12-13T16:25:32Z
biological_process
GO:0044765
single-organism transport
The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving a single organism.
GOC:jl
A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, involving only one organism.
janelomax
2012-12-19T12:21:31Z
biological_process
GO:0044767
single-organism developmental process
A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, involving only one organism.
GOC:jl
The cell cycle process by which a cell commits to entering the next cell cycle phase.
janelomax
2013-02-28T12:54:59Z
cell cycle transition
biological_process
GO:0044770
cell cycle phase transition
The cell cycle process by which a cell commits to entering the next cell cycle phase.
GOC:mtg_cell_cycle
The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase.
janelomax
2013-02-28T13:09:33Z
biological_process
GO:0044772
mitotic cell cycle phase transition
The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase.
GOC:mtg_cell_cycle
The membrane organization process that joins two lipid bilayers to form a single membrane, involving only one organism.
janelomax
2013-09-10T15:08:20Z
biological_process
GO:0044801
single-organism membrane fusion
The membrane organization process that joins two lipid bilayers to form a single membrane, involving only one organism.
GOC:jl
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane, involving only one organism.
janelomax
2013-09-10T15:11:17Z
biological_process
GO:0044802
single-organism membrane organization
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane, involving only one organism.
GOC:jl
The cell cycle process by which a cell in G2 phase commits to M phase.
janelomax
2014-03-05T14:56:45Z
biological_process
GO:0044839
cell cycle G2/M phase transition
The cell cycle process by which a cell in G2 phase commits to M phase.
GOC:jl
GOC:mtg_cell_cycle
A distinct period or stage in a biological process or cycle.
janelomax
2014-07-16T13:12:40Z
biological_process
GO:0044848
Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase.
biological phase
A distinct period or stage in a biological process or cycle.
GOC:jl
The mitotic cell cycle phase transition whose occurrence commits the cell from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression.
biological_process
GO:0045023
G0 to G1 transition
The mitotic cell cycle phase transition whose occurrence commits the cell from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression.
GOC:mtg_cell_cycle
ISBN:0716731363
The joining of two or more lipid bilayer membranes that surround a cell.
GO:0006947
cell fusion
cell-cell fusion
biological_process
GO:0045026
plasma membrane fusion
The joining of two or more lipid bilayer membranes that surround a cell.
GOC:elh
GOC:mtg_muscle
The directed movement of a protein to a specific location.
establishment of protein localisation
protein positioning
protein recruitment
biological_process
GO:0045184
establishment of protein localization
The directed movement of a protein to a specific location.
GOC:bf
establishment of protein localisation
GOC:mah
Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away.
active protein retrieval
protein retention
protein sequestering
biological_process
maintenance of protein localization
GO:0045185
maintenance of protein location
Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away.
GOC:bf
maintenance of protein localization
GOC:dph
GOC:tb
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
Wikipedia:Phagosome
phagosome
cellular_component
GO:0045335
phagocytic vesicle
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
GOC:go_curators
ISBN:0198506732
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
GO:0016481
GO:0032582
GO:0061021
down regulation of transcription, DNA-dependent
down-regulation of transcription, DNA-dependent
downregulation of transcription, DNA-dependent
negative regulation of cellular transcription, DNA-dependent
negative regulation of transcription, DNA-dependent
inhibition of transcription, DNA-dependent
biological_process
down regulation of gene-specific transcription
down-regulation of gene-specific transcription
downregulation of gene-specific transcription
inhibition of gene-specific transcription
negative regulation of gene-specific transcription
transcription repressor activity
GO:0045892
negative regulation of transcription, DNA-templated
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
GOC:go_curators
GOC:txnOH
negative regulation of transcription, DNA-dependent
GOC:txnOH
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
GO:0043193
GO:0045941
GO:0061020
positive regulation of cellular transcription, DNA-dependent
positive regulation of transcription, DNA-dependent
up regulation of transcription, DNA-dependent
up-regulation of transcription, DNA-dependent
upregulation of transcription, DNA-dependent
activation of transcription, DNA-dependent
stimulation of gene-specific transcription
stimulation of transcription, DNA-dependent
biological_process
activation of gene-specific transcription
positive regulation of gene-specific transcription
transcription activator activity
up regulation of gene-specific transcription
up-regulation of gene-specific transcription
upregulation of gene-specific transcription
GO:0045893
positive regulation of transcription, DNA-templated
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
GOC:go_curators
GOC:txnOH
positive regulation of transcription, DNA-dependent
GOC:txnOH
Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
biological_process
negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GO:0045934
negative regulation of nucleobase-containing compound metabolic process
Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
GOC:go_curators
negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GOC:dph
GOC:tb
Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
up regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
upregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
activation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
stimulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
biological_process
positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GO:0045935
positive regulation of nucleobase-containing compound metabolic process
Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
GOC:go_curators
positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GOC:dph
GOC:tb
The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
heterocycle metabolism
biological_process
GO:0046483
heterocycle metabolic process
The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
CHEBI:5686
ISBN:0198506732
The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
heterocycle breakdown
heterocycle catabolism
heterocycle degradation
biological_process
GO:0046700
heterocycle catabolic process
The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
GOC:ai
Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm.
biological_process
GO:0046822
regulation of nucleocytoplasmic transport
Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm.
GOC:bf
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus.
down regulation of nucleocytoplasmic transport
down-regulation of nucleocytoplasmic transport
downregulation of nucleocytoplasmic transport
inhibition of nucleocytoplasmic transport
biological_process
GO:0046823
negative regulation of nucleocytoplasmic transport
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus.
GOC:bf
Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm.
up regulation of nucleocytoplasmic transport
up-regulation of nucleocytoplasmic transport
upregulation of nucleocytoplasmic transport
activation of nucleocytoplasmic transport
stimulation of nucleocytoplasmic transport
biological_process
GO:0046824
positive regulation of nucleocytoplasmic transport
Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm.
GOC:bf
The controlled release of a substance by a cell or a tissue.
biological_process
GO:0046903
secretion
The controlled release of a substance by a cell or a tissue.
GOC:ai
The directed movement of substances within a cell.
biological_process
GO:0046907
intracellular transport
The directed movement of substances within a cell.
GOC:ai
The creation of two or more organelles by division of one organelle.
biological_process
GO:0048285
organelle fission
The creation of two or more organelles by division of one organelle.
GOC:jid
The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
biological_process
terminal differentiation
GO:0048468
cell development
The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
GOC:go_curators
terminal differentiation
GOC:dph
GOC:tb
Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0043119
positive regulation of physiological process
up regulation of biological process
up-regulation of biological process
upregulation of biological process
activation of biological process
stimulation of biological process
biological_process
GO:0048518
positive regulation of biological process
Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GOC:jid
Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0043118
down regulation of biological process
down-regulation of biological process
downregulation of biological process
negative regulation of physiological process
inhibition of biological process
biological_process
GO:0048519
negative regulation of biological process
Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GOC:jid
Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0051242
positive regulation of cellular physiological process
up regulation of cellular process
up-regulation of cellular process
upregulation of cellular process
activation of cellular process
stimulation of cellular process
biological_process
GO:0048522
positive regulation of cellular process
Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GOC:jid
Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0051243
down regulation of cellular process
down-regulation of cellular process
downregulation of cellular process
negative regulation of cellular physiological process
inhibition of cellular process
biological_process
GO:0048523
negative regulation of cellular process
Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GOC:jid
Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
biological_process
GO:0048583
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
regulation of response to stimulus
Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
GOC:jid
Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
up regulation of response to stimulus
up-regulation of response to stimulus
upregulation of response to stimulus
activation of response to stimulus
stimulation of response to stimulus
biological_process
GO:0048584
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
positive regulation of response to stimulus
Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
GOC:jid
Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
down regulation of response to stimulus
down-regulation of response to stimulus
downregulation of response to stimulus
inhibition of response to stimulus
biological_process
GO:0048585
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
negative regulation of response to stimulus
Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
GOC:jid
The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
biological_process
GO:0048589
developmental growth
The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
GOC:go_curators
The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
development of an anatomical structure
biological_process
GO:0048856
This term was added by GO_REF:0000021.
anatomical structure development
The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
GOC:mtg_15jun06
GO_REF:0000021
A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
biological_process
GO:0048869
cellular developmental process
A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
GOC:isa_complete
Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
cell locomotion
movement of a cell
biological_process
cell movement
GO:0048870
cell motility
Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
GOC:dgh
GOC:dph
GOC:isa_complete
GOC:mlg
Any process in which a chromosome is transported to, or maintained in, a specific location.
chromosome localisation
establishment and maintenance of chromosome localization
establishment and maintenance of chromosome position
biological_process
GO:0050000
chromosome localization
Any process in which a chromosome is transported to, or maintained in, a specific location.
GOC:ai
chromosome localisation
GOC:mah
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0050791
regulation of physiological process
biological_process
GO:0050789
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GOC:ai
GOC:go_curators
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0051244
regulation of cellular physiological process
biological_process
GO:0050794
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GOC:go_curators
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
GO:0051869
physiological response to stimulus
biological_process
GO:0050896
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
response to stimulus
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
GOC:ai
GOC:bf
Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
biological_process
GO:0051049
regulation of transport
Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GOC:ai
Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
up regulation of transport
up-regulation of transport
upregulation of transport
activation of transport
stimulation of transport
biological_process
GO:0051050
positive regulation of transport
Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GOC:ai
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
down regulation of transport
down-regulation of transport
downregulation of transport
inhibition of transport
biological_process
GO:0051051
negative regulation of transport
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GOC:ai
Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
regulation of transcription factor activity
Reactome:REACT_104536
Reactome:REACT_107559
Reactome:REACT_109535
Reactome:REACT_110257
Reactome:REACT_110693
Reactome:REACT_21326
Reactome:REACT_82719
Reactome:REACT_83365
Reactome:REACT_90659
Reactome:REACT_92725
Reactome:REACT_96476
Reactome:REACT_99415
biological_process
GO:0051090
regulation of sequence-specific DNA binding transcription factor activity
Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
GOC:ai
regulation of transcription factor activity
GOC:dph
GOC:tb
Reactome:REACT_104536
Activation of the AP-1 family of transcription factors, Bos taurus
Reactome:REACT_107559
Activation of the AP-1 family of transcription factors, Danio rerio
Reactome:REACT_109535
Activation of the AP-1 family of transcription factors, Schizosaccharomyces pombe
Reactome:REACT_110257
Activation of the AP-1 family of transcription factors, Drosophila melanogaster
Reactome:REACT_110693
Activation of the AP-1 family of transcription factors, Gallus gallus
Reactome:REACT_21326
Activation of the AP-1 family of transcription factors, Homo sapiens
Reactome:REACT_82719
Activation of the AP-1 family of transcription factors, Xenopus tropicalis
Reactome:REACT_83365
Activation of the AP-1 family of transcription factors, Sus scrofa
Reactome:REACT_90659
Activation of the AP-1 family of transcription factors, Taeniopygia guttata
Reactome:REACT_92725
Activation of the AP-1 family of transcription factors, Canis familiaris
Reactome:REACT_96476
Activation of the AP-1 family of transcription factors, Rattus norvegicus
Reactome:REACT_99415
Activation of the AP-1 family of transcription factors, Mus musculus
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
positive regulation of transcription factor activity
up regulation of transcription factor activity
up-regulation of transcription factor activity
upregulation of transcription factor activity
activation of transcription factor activity
stimulation of transcription factor activity
biological_process
GO:0051091
positive regulation of sequence-specific DNA binding transcription factor activity
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
GOC:ai
positive regulation of transcription factor activity
GOC:dph
GOC:tb
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
Reactome:REACT_107873
Reactome:REACT_113398
Reactome:REACT_113766
Reactome:REACT_21281
Reactome:REACT_31084
Reactome:REACT_33907
Reactome:REACT_34168
Reactome:REACT_34256
Reactome:REACT_87914
Reactome:REACT_95400
NF-kappaB activation
activation of NF-kappaB
activation of NF-kappaB transcription factor
biological_process
GO:0051092
positive regulation of NF-kappaB transcription factor activity
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
GOC:dph
GOC:tb
PMID:15087454
PMID:15170030
Reactome:REACT_107873
TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Rattus norvegicus
Reactome:REACT_113398
TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Taeniopygia guttata
Reactome:REACT_113766
TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Drosophila melanogaster
Reactome:REACT_21281
TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Homo sapiens
Reactome:REACT_31084
TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Canis familiaris
Reactome:REACT_33907
TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Danio rerio
Reactome:REACT_34168
TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Sus scrofa
Reactome:REACT_34256
TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Bos taurus
Reactome:REACT_87914
TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Xenopus tropicalis
Reactome:REACT_95400
TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Mus musculus
activation of NF-kappaB transcription factor
GOC:dph
GOC:tb
The directed movement of substances into, out of, or within the nucleus.
Reactome:REACT_9004
Wikipedia:Nuclear_transport
nucleus transport
biological_process
GO:0051169
nuclear transport
The directed movement of substances into, out of, or within the nucleus.
GOC:ai
Reactome:REACT_9004
Import of PIC to the Host Nucleus, Homo sapiens
The directed movement of substances into the nucleus.
Reactome:REACT_10010
Reactome:REACT_32050
Reactome:REACT_91459
Reactome:REACT_97007
import into nucleus
nucleus import
substance nuclear import
biological_process
GO:0051170
nuclear import
The directed movement of substances into the nucleus.
GOC:ai
Reactome:REACT_10010
snRNP nuclear import and release, Homo sapiens
Reactome:REACT_32050
snRNP nuclear import and release, Xenopus tropicalis
Reactome:REACT_91459
snRNP nuclear import and release, Mus musculus
Reactome:REACT_97007
snRNP nuclear import and release, Danio rerio
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds.
regulation of nitrogen metabolic process
regulation of nitrogen metabolism
biological_process
GO:0051171
regulation of nitrogen compound metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds.
GOC:ai
GOC:tb
regulation of nitrogen metabolic process
GOC:tb
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds.
down regulation of nitrogen metabolic process
down-regulation of nitrogen metabolic process
downregulation of nitrogen metabolic process
negative regulation of nitrogen metabolic process
negative regulation of nitrogen metabolism
inhibition of nitrogen metabolic process
biological_process
GO:0051172
negative regulation of nitrogen compound metabolic process
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds.
GOC:ai
GOC:tb
negative regulation of nitrogen metabolic process
GOC:tb
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds.
positive regulation of nitrogen metabolic process
positive regulation of nitrogen metabolism
up regulation of nitrogen metabolic process
up-regulation of nitrogen metabolic process
upregulation of nitrogen metabolic process
activation of nitrogen metabolic process
stimulation of nitrogen metabolic process
biological_process
GO:0051173
positive regulation of nitrogen compound metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds.
GOC:ai
GOC:tb
positive regulation of nitrogen metabolic process
GOC:tb
Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to or maintained in a specific location.
establishment and maintenance of localization
establishment and maintenance of position
localisation
establishment and maintenance of cellular component location
establishment and maintenance of substance location
establishment and maintenance of substrate location
biological_process
GO:0051179
localization
Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to or maintained in a specific location.
GOC:ai
localisation
GOC:mah
The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell.
cytoplasmic retention of protein
cytoplasmic sequestration of protein
cytoplasmic storage of protein
maintenance of protein location in cytoplasm
retention of protein in cytoplasm
sequestering of protein in cytoplasm
sequestration of protein in cytoplasm
storage of protein in cytoplasm
biological_process
GO:0051220
cytoplasmic sequestering of protein
The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell.
GOC:ai
maintenance of protein location in cytoplasm
GOC:dph
GOC:tb
Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
up regulation of protein transport
up-regulation of protein transport
upregulation of protein transport
activation of protein transport
stimulation of protein transport
biological_process
GO:0051222
positive regulation of protein transport
Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GOC:ai
Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
biological_process
GO:0051223
regulation of protein transport
Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GOC:ai
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
down regulation of protein transport
down-regulation of protein transport
downregulation of protein transport
inhibition of protein transport
biological_process
GO:0051224
negative regulation of protein transport
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GOC:ai
The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.
establishment of localisation
biological_process
GO:0051234
establishment of localization
The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.
GOC:ai
establishment of localisation
GOC:mah
Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere.
retention
sequestering
storage
biological_process
GO:0051235
maintenance of location
Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere.
GOC:ai
GOC:dph
GOC:tb
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.
regulation of RNA metabolism
biological_process
GO:0051252
regulation of RNA metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.
GOC:ai
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA.
down regulation of RNA metabolic process
down-regulation of RNA metabolic process
downregulation of RNA metabolic process
negative regulation of RNA metabolism
inhibition of RNA metabolic process
biological_process
GO:0051253
negative regulation of RNA metabolic process
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA.
GOC:ai
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA.
positive regulation of RNA metabolism
up regulation of RNA metabolic process
up-regulation of RNA metabolic process
upregulation of RNA metabolic process
activation of RNA metabolic process
stimulation of RNA metabolic process
biological_process
GO:0051254
positive regulation of RNA metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA.
GOC:ai
A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.
GO:0007001
GO:0051277
chromosome organisation
biological_process
chromosome organization and biogenesis
maintenance of genome integrity
nuclear genome maintenance
GO:0051276
chromosome organization
A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.
GOC:ai
GOC:dph
GOC:jl
GOC:mah
chromosome organization and biogenesis
GOC:mah
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
centrosome organisation
biological_process
centrosome organization and biogenesis
GO:0051297
centrosome organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
GOC:ai
GOC:dph
GOC:jl
GOC:mah
centrosome organisation
GOC:curators
centrosome organization and biogenesis
GOC:mah
The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
centrosome replication
biological_process
GO:0051298
centrosome duplication
The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
GOC:ai
The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
Wikipedia:Cell_division
biological_process
GO:0051301
Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division.
cell division
The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
GOC:di
GOC:go_curators
GOC:pr
The directed movement of a chromosome to a specific location.
chromosome positioning
establishment of chromosome localisation
biological_process
GO:0051303
establishment of chromosome localization
The directed movement of a chromosome to a specific location.
GOC:ai
establishment of chromosome localisation
GOC:mah
The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle.
chromosome congression
biological_process
GO:0051310
metaphase plate congression
The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle.
GOC:ai
chromosome congression
GOC:ascb_2009
GOC:dph
GOC:tb
The alteration of chromosome structure from the condensed form to a relaxed disperse form.
biological_process
GO:0051312
chromosome decondensation
The alteration of chromosome structure from the condensed form to a relaxed disperse form.
GOC:ai
The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis.
Wikipedia:G1_phase
biological_process
GO:0051318
Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
G1 phase
The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis.
GOC:mtg_cell_cycle
The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis).
Wikipedia:G2_phase
biological_process
GO:0051319
Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
G2 phase
The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis).
GOC:mtg_cell_cycle
The cell cycle phase, following G1, during which DNA synthesis takes place.
Wikipedia:S_phase
S-phase
biological_process
GO:0051320
Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
S phase
The cell cycle phase, following G1, during which DNA synthesis takes place.
GOC:mtg_cell_cycle
The cell cycle phase, following metaphase, during which the chromosomes separate and migrate towards the poles of the spindle.
Wikipedia:Anaphase
biological_process
GO:0051322
Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
anaphase
The cell cycle phase, following metaphase, during which the chromosomes separate and migrate towards the poles of the spindle.
GOC:mtg_cell_cycle
The cell cycle phase, following prophase or prometaphase in higher eukaryotes, during which chromosomes become aligned on the equatorial plate of the cell.
Wikipedia:Metaphase
biological_process
GO:0051323
Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
metaphase
The cell cycle phase, following prophase or prometaphase in higher eukaryotes, during which chromosomes become aligned on the equatorial plate of the cell.
GOC:mtg_cell_cycle
The cell cycle phase which is the first stage of M phase of meiosis and mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.
Wikipedia:Prophase
biological_process
GO:0051324
Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
prophase
The cell cycle phase which is the first stage of M phase of meiosis and mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.
GOC:mtg_cell_cycle
The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs.
resting phase
Wikipedia:Interphase
karyostasis
biological_process
GO:0051325
Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
interphase
The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs.
GOC:mtg_cell_cycle
The cell cycle phase which follows anaphase during M phase of mitosis and meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.
Wikipedia:Telophase
biological_process
GO:0051326
note that this term should not be used for direct annotation. if you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic s-phase). to capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
telophase
The cell cycle phase which follows anaphase during M phase of mitosis and meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.
GOC:mtg_cell_cycle
The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when mitotic prophase begins. During interphase the cell readies itself for mitosis and the replication of its DNA occurs.
interphase of mitotic cell cycle
biological_process
GO:0051329
Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
mitotic interphase
The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when mitotic prophase begins. During interphase the cell readies itself for mitosis and the replication of its DNA occurs.
GOC:mtg_cell_cycle
Any process in which an organelle is transported to, and/or maintained in, a specific location.
establishment and maintenance of organelle localization
organelle localisation
biological_process
GO:0051640
organelle localization
Any process in which an organelle is transported to, and/or maintained in, a specific location.
GOC:ai
organelle localisation
GOC:mah
A localization process that takes place at the cellular level; as a result of a cellular localization process, a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.
cellular localisation
establishment and maintenance of cellular localization
establishment and maintenance of localization in cell or cell membrane
intracellular localization
localization within cell
biological_process
GO:0051641
cellular localization
A localization process that takes place at the cellular level; as a result of a cellular localization process, a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.
GOC:ai
GOC:mah
cellular localisation
GOC:mah
The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.
establishment of localisation in cell
establishment of intracellular localization
establishment of localization within cell
positioning within cell
biological_process
establishment of cellular localization
GO:0051649
establishment of localization in cell
The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.
GOC:ai
GOC:dph
GOC:tb
establishment of localisation in cell
GOC:mah
establishment of cellular localization
GOC:dph
GOC:tb
Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.
cellular retention
cellular sequestering
cellular storage
intracellular retention
intracellular sequestering
intracellular storage
maintenance of intracellular localization
maintenance of localization within cell
retention within cell
sequestering within cell
storage within cell
biological_process
maintenance of cellular localization
maintenance of localization in cell
GO:0051651
maintenance of location in cell
Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.
GOC:ai
maintenance of cellular localization
GOC:dph
GOC:tb
maintenance of localization in cell
GOC:dph
GOC:tb
The directed movement of an organelle to a specific location.
establishment of organelle localisation
biological_process
GO:0051656
establishment of organelle localization
The directed movement of an organelle to a specific location.
GOC:ai
establishment of organelle localisation
GOC:mah
Any process in which a cell is transported to, and/or maintained in, a specific location.
cell localization
establishment and maintenance of cell localization
establishment and maintenance of localization of cell
localisation of cell
biological_process
GO:0051674
localization of cell
Any process in which a cell is transported to, and/or maintained in, a specific location.
GOC:ai
localisation of cell
GOC:mah
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.
biological_process
GO:0051716
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
cellular response to stimulus
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.
GOC:bf
GOC:jl
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
biological_process
GO:0060255
regulation of macromolecule metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
GOC:dph
GOC:tb
Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell.
regulation of cellular localisation
biological_process
GO:0060341
regulation of cellular localization
Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell.
GOC:dph
GOC:tb
regulation of cellular localisation
GOC:mah
The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape.
dph
2009-04-28T08:42:53Z
differential growth
biological_process
GO:0060560
developmental growth involved in morphogenesis
The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape.
GOC:dph
differential growth
GOC:dph
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
dph
2010-02-08T02:43:11Z
GO:0016044
Reactome:REACT_101524
Reactome:REACT_103082
Reactome:REACT_11123
Reactome:REACT_29278
Reactome:REACT_32337
Reactome:REACT_33741
Reactome:REACT_34084
Reactome:REACT_78213
Reactome:REACT_78288
Reactome:REACT_83546
Reactome:REACT_86557
Reactome:REACT_87431
Reactome:REACT_88307
Reactome:REACT_91154
Reactome:REACT_93714
Reactome:REACT_95586
Reactome:REACT_96516
Reactome:REACT_97881
cellular membrane organisation
cellular membrane organization
membrane organisation
biological_process
membrane organization and biogenesis
GO:0061024
membrane organization
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
GOC:dph
GOC:tb
Reactome:REACT_101524
Membrane Trafficking, Dictyostelium discoideum
Reactome:REACT_103082
Membrane Trafficking, Schizosaccharomyces pombe
Reactome:REACT_11123
Membrane Trafficking, Homo sapiens
Reactome:REACT_29278
Membrane Trafficking, Sus scrofa
Reactome:REACT_32337
Membrane Trafficking, Taeniopygia guttata
Reactome:REACT_33741
Membrane Trafficking, Bos taurus
Reactome:REACT_34084
Membrane Trafficking, Caenorhabditis elegans
Reactome:REACT_78213
Membrane Trafficking, Plasmodium falciparum
Reactome:REACT_78288
Membrane Trafficking, Xenopus tropicalis
Reactome:REACT_83546
Membrane Trafficking, Oryza sativa
Reactome:REACT_86557
Membrane Trafficking, Arabidopsis thaliana
Reactome:REACT_87431
Membrane Trafficking, Drosophila melanogaster
Reactome:REACT_88307
Membrane Trafficking, Mus musculus
Reactome:REACT_91154
Membrane Trafficking, Saccharomyces cerevisiae
Reactome:REACT_93714
Membrane Trafficking, Danio rerio
Reactome:REACT_95586
Membrane Trafficking, Gallus gallus
Reactome:REACT_96516
Membrane Trafficking, Canis familiaris
Reactome:REACT_97881
Membrane Trafficking, Rattus norvegicus
cellular membrane organisation
GOC:curators
membrane organisation
GOC:mah
membrane organization and biogenesis
GOC:mah
The membrane organization process that joins two lipid bilayers to form a single membrane.
dph
2010-02-08T02:48:06Z
GO:0006944
Wikipedia:Lipid_bilayer_fusion
cellular membrane fusion
biological_process
GO:0061025
membrane fusion
The membrane organization process that joins two lipid bilayers to form a single membrane.
GOC:dph
GOC:tb
The endoplasmic reticulum organization process that results in the structure of the endoplasmic reticulum being oriented in the cell.
dph
2010-06-25T09:51:48Z
biological_process
GO:0061163
endoplasmic reticulum polarization
The endoplasmic reticulum organization process that results in the structure of the endoplasmic reticulum being oriented in the cell.
GOC:dph
GOC:vw
Any process that modulates a measurable attribute of any biological process, quality or function.
regulation
biological_process
GO:0065007
biological regulation
Any process that modulates a measurable attribute of any biological process, quality or function.
GOC:dph
GOC:isa_complete
GOC:mah
GOC:pr
GOC:vw
Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.
regulation of biological attribute
regulation of biological characteristic
biological_process
GO:0065008
regulation of biological quality
Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.
GOC:dph
GOC:isa_complete
GOC:mah
GOC:pr
GOC:vw
Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
regulation of a molecular function
biological_process
GO:0065009
regulation of molecular function
Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
GOC:isa_complete
An organelle lumen that is part of an intracellular organelle.
cellular_component
GO:0070013
intracellular organelle lumen
An organelle lumen that is part of an intracellular organelle.
GOC:mah
A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
anchoring cell junction
cellular_component
GO:0070161
anchoring junction
A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
ISBN:0815332181
anchoring cell junction
GOC:mah
Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location.
regulation of establishment of protein localisation
biological_process
GO:0070201
regulation of establishment of protein localization
Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location.
GOC:BHF
GOC:mah
regulation of establishment of protein localisation
GOC:mah
The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body.
biological_process
GO:0070252
actin-mediated cell contraction
The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body.
GOC:mah
A process in which a protein is transported to, or maintained in, a location within the mitochondrion.
midori
2009-04-24T02:31:18Z
protein localisation in mitochondrion
protein localization in mitochondrion
biological_process
GO:0070585
protein localization to mitochondrion
A process in which a protein is transported to, or maintained in, a location within the mitochondrion.
GOC:ecd
protein localisation in mitochondrion
GOC:mah
protein localization in mitochondrion
GOC:curators
Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
midori
2009-06-16T04:08:29Z
cellular macromolecule localisation
biological_process
GO:0070727
cellular macromolecule localization
Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
GOC:mah
cellular macromolecule localisation
GOC:mah
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
midori
2009-08-27T04:41:45Z
biological_process
GO:0070887
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
cellular response to chemical stimulus
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
GOC:mah
The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
midori
2009-09-15T03:00:51Z
biological_process
GO:0070925
organelle assembly
The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
GOC:mah
A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum.
midori
2009-10-02T12:43:34Z
protein localisation in endoplasmic reticulum
protein localization in ER
protein localization in endoplasmic reticulum
biological_process
GO:0070972
protein localization to endoplasmic reticulum
A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum.
GOC:mah
protein localisation in endoplasmic reticulum
GOC:mah
protein localization in ER
GOC:mah
protein localization in endoplasmic reticulum
GOC:curators
A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule.
midori
2009-11-09T11:36:34Z
DNA conformation modification
biological_process
GO:0071103
DNA conformation change
A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule.
GOC:mah
DNA conformation modification
GOC:mah
A process in which a protein is transported to, or maintained at, the centrosome.
midori
2010-01-12T02:09:45Z
protein localisation to centrosome
biological_process
GO:0071539
protein localization to centrosome
A process in which a protein is transported to, or maintained at, the centrosome.
GOC:ecd
protein localisation to centrosome
GOC:mah
The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon.
midori
2010-03-08T02:15:14Z
biological_process
GO:0071702
organic substance transport
The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon.
CHEBI:50860
GOC:mah
The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.
midori
2010-03-08T03:32:18Z
organic molecular entity metabolic process
organic molecular entity metabolism
organic substance metabolism
biological_process
GO:0071704
organic substance metabolic process
The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.
CHEBI:50860
GOC:mah
The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
midori
2010-03-08T03:56:28Z
biological_process
GO:0071705
nitrogen compound transport
The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
CHEBI:51143
GOC:mah
A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.
midori
2010-09-10T01:39:16Z
GO:0071841
cellular component organisation or biogenesis
cellular component organisation or biogenesis at cellular level
cellular component organization or biogenesis at cellular level
biological_process
GO:0071840
cellular component organization or biogenesis
A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.
GOC:mah
cellular component organisation or biogenesis
GOC:mah
cellular component organisation or biogenesis at cellular level
GOC:mah
The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.
midori
2010-09-15T02:14:33Z
DNA anabolism
DNA biosynthesis
DNA formation
DNA synthesis
biological_process
GO:0071897
DNA biosynthetic process
The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.
GOC:mah
DNA anabolism
GOC:mah
DNA biosynthesis
GOC:mah
DNA formation
GOC:mah
DNA synthesis
GOC:mah
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
midori
2010-10-04T01:51:47Z
cellular_component
GO:0071944
cell periphery
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
GOC:mah
The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle.
midori
2011-02-14T01:56:51Z
establishment of protein localisation to organelle
biological_process
GO:0072594
establishment of protein localization to organelle
The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle.
GOC:mah
establishment of protein localisation to organelle
GOC:mah
A process in which a protein is transported to, or maintained in, a specific location in a membrane.
midori
2011-02-14T02:35:18Z
protein localisation in membrane
protein localization in membrane
biological_process
GO:0072657
protein localization to membrane
A process in which a protein is transported to, or maintained in, a specific location in a membrane.
GOC:mah
protein localisation in membrane
GOC:mah
protein localization in membrane
GOC:curators
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
midori
2011-02-14T02:43:05Z
protein localisation in plasma membrane
protein localization in plasma membrane
biological_process
GO:0072659
protein localization to plasma membrane
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
GOC:mah
protein localisation in plasma membrane
GOC:mah
protein localization in plasma membrane
GOC:curators
A process in which a protein is transported to, or maintained at, a location in a peroxisome.
midori
2011-02-14T02:50:04Z
protein localisation to peroxisome
biological_process
GO:0072662
protein localization to peroxisome
A process in which a protein is transported to, or maintained at, a location in a peroxisome.
GOC:ecd
protein localisation to peroxisome
GOC:mah
A process in which a protein is transported to, or maintained at, a location in a vacuole.
midori
2011-02-14T02:55:35Z
protein localisation to vacuole
biological_process
GO:0072665
protein localization to vacuole
A process in which a protein is transported to, or maintained at, a location in a vacuole.
GOC:ecd
protein localisation to vacuole
GOC:mah
A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton.
midori
2012-04-11T01:19:35Z
protein localisation to microtubule cytoskeleton
biological_process
GO:0072698
protein localization to microtubule cytoskeleton
A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton.
GOC:mah
protein localisation to microtubule cytoskeleton
GOC:mah
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
donghui
2009-04-22T04:30:52Z
biological_process
GO:0080090
regulation of primary metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
PMID:19211694
Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
tanyaberardini
2009-10-23T11:21:38Z
biological_process
GO:0090087
regulation of peptide transport
Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GOC:dph
GOC:tb
A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes.
tanyaberardini
2009-12-08T03:06:36Z
biological_process
GO:0090148
membrane fission
A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes.
GOC:ascb_2009
GOC:dph
GOC:tb
A process in which a protein is transported to, or maintained in, a nuclear pore.
tanyaberardini
2009-12-18T12:05:01Z
protein localisation to nuclear pore
biological_process
GO:0090204
protein localization to nuclear pore
A process in which a protein is transported to, or maintained in, a nuclear pore.
GOC:dph
GOC:rb
GOC:tb
protein localisation to nuclear pore
GOC:mah
Any cellular metabolic process involving nucleic acids.
tanyaberardini
2010-04-07T10:18:47Z
biological_process
GO:0090304
nucleic acid metabolic process
Any cellular metabolic process involving nucleic acids.
GOC:dph
GOC:tb
The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis.
tanyaberardini
2010-04-07T10:26:30Z
nucleic acid cleavage
biological_process
GO:0090305
nucleic acid phosphodiester bond hydrolysis
The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis.
GOC:dph
GOC:tb
nucleic acid cleavage
GOC:dph
GOC:tb
Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells.
tanyaberardini
2010-04-16T03:45:07Z
biological_process
GO:0090316
positive regulation of intracellular protein transport
Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells.
GOC:tb
Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells.
tanyaberardini
2010-04-16T03:45:07Z
biological_process
GO:0090317
negative regulation of intracellular protein transport
Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells.
GOC:tb
A process in which a protein is transported to, or maintained at, a location within a nuclear envelope.
tanyaberardini
2012-07-30T01:50:41Z
protein localization in nuclear envelope
biological_process
GO:0090435
protein localization to nuclear envelope
A process in which a protein is transported to, or maintained at, a location within a nuclear envelope.
GOC:tb
protein localization in nuclear envelope
GOC:curators
Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure.
paola
2011-09-23T02:31:01Z
molecular_function
GO:0097159
organic cyclic compound binding
Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure.
CHEBI:33832
GOC:sjw
PMID:7583672
A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
paola
2011-11-23T09:45:24Z
execution phase of apoptotic process
apoptosis
biological_process
GO:0097194
execution phase of apoptosis
A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
GOC:mtg_apoptosis
PMID:21760595
A process in which a protein is transported to, or maintained at, a location within a cellular bud neck.
paola
2012-03-20T03:39:20Z
protein localisation to bud neck
protein localization to cellular bud neck
biological_process
GO:0097271
protein localization to bud neck
A process in which a protein is transported to, or maintained at, a location within a cellular bud neck.
GOC:rb
PMID:22344253
protein localisation to bud neck
GOC:mah
An arrangement of closely apposed microtubules running parallel to each other.
paola
2012-11-07T15:01:27Z
NIF_Subcellular:sao1872343973
microtubule fascicle
cellular_component
GO:0097427
microtubule bundle
An arrangement of closely apposed microtubules running parallel to each other.
NIF_Subcellular:sao1872343973
Any constituent part of a neuron, the basic cellular unit of nervous tissue. A typical neuron consists of a cell body (often called the soma), an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
paola
2012-12-19T16:53:50Z
cellular_component
GO:0097458
neuron part
Any constituent part of a neuron, the basic cellular unit of nervous tissue. A typical neuron consists of a cell body (often called the soma), an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
GOC:pr
http://en.wikipedia.org/wiki/Neuron
The cellular synthesis of RNA on a template of nucleic acid (DNA or RNA).
paola
2014-10-01T13:49:27Z
biological_process
GO:0097659
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
nucleic acid-templated transcription
The cellular synthesis of RNA on a template of nucleic acid (DNA or RNA).
GOC:pr
GOC:txnOH
GOC:vw
A cellular process that results in the assembly of one or more centrioles.
davidos
2013-10-22T15:55:22Z
biological_process
GO:0098534
centriole assembly
A cellular process that results in the assembly of one or more centrioles.
GOC:dos
PMID:24075808
The attachment, via cell adhesion molecules, of a cell to either another cell of the same organism, or to an underlying substrate of the same organism such as the extracellular matrix.
davidos
2014-04-15T15:59:10Z
biological_process
GO:0098602
single organism cell adhesion
The attachment, via cell adhesion molecules, of a cell to either another cell of the same organism, or to an underlying substrate of the same organism such as the extracellular matrix.
GOC:dos
Any subdivision of a chromosome along its length.
chromosome region
cellular_component
GO:0098687
Chromosomal regions include parts that are not part of the chromatin. Examples include the kinetochore.
chromosomal region
Any subdivision of a chromosome along its length.
GOC:dos
One of the distinct periods or stages into which the mitotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
biological_process
GO:0098763
mitotic cell cycle phase
One of the distinct periods or stages into which the mitotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
GOC:dos
The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
biological_process
GO:0098813
nuclear chromosome segregation
The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
GOC:dos
Any process that modulates the frequency, rate or extent of protein localization to nucleus.
bf
2012-03-12T01:23:44Z
regulation of protein localisation to nucleus
regulation of protein localization in cell nucleus
regulation of protein localization in nucleus
biological_process
GO:1900180
regulation of protein localization to nucleus
Any process that modulates the frequency, rate or extent of protein localization to nucleus.
GOC:TermGenie
regulation of protein localisation to nucleus
GOC:TermGenie
regulation of protein localization in cell nucleus
GOC:TermGenie
regulation of protein localization in nucleus
GOC:TermGenie
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus.
bf
2012-03-12T01:23:48Z
down regulation of protein localisation to nucleus
down regulation of protein localization in cell nucleus
down regulation of protein localization in nucleus
down regulation of protein localization to nucleus
down-regulation of protein localisation to nucleus
down-regulation of protein localization in cell nucleus
down-regulation of protein localization in nucleus
down-regulation of protein localization to nucleus
downregulation of protein localisation to nucleus
downregulation of protein localization in cell nucleus
downregulation of protein localization in nucleus
downregulation of protein localization to nucleus
negative regulation of protein localisation to nucleus
negative regulation of protein localization in cell nucleus
negative regulation of protein localization in nucleus
inhibition of protein localisation to nucleus
inhibition of protein localization in cell nucleus
inhibition of protein localization in nucleus
inhibition of protein localization to nucleus
biological_process
GO:1900181
negative regulation of protein localization to nucleus
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus.
GOC:TermGenie
down regulation of protein localisation to nucleus
GOC:TermGenie
down regulation of protein localization in cell nucleus
GOC:TermGenie
down regulation of protein localization in nucleus
GOC:TermGenie
down regulation of protein localization to nucleus
GOC:TermGenie
down-regulation of protein localisation to nucleus
GOC:TermGenie
down-regulation of protein localization in cell nucleus
GOC:TermGenie
down-regulation of protein localization in nucleus
GOC:TermGenie
down-regulation of protein localization to nucleus
GOC:TermGenie
downregulation of protein localisation to nucleus
GOC:TermGenie
downregulation of protein localization in cell nucleus
GOC:TermGenie
downregulation of protein localization in nucleus
GOC:TermGenie
downregulation of protein localization to nucleus
GOC:TermGenie
negative regulation of protein localisation to nucleus
GOC:TermGenie
negative regulation of protein localization in cell nucleus
GOC:TermGenie
negative regulation of protein localization in nucleus
GOC:TermGenie
inhibition of protein localisation to nucleus
GOC:TermGenie
inhibition of protein localization in cell nucleus
GOC:TermGenie
inhibition of protein localization in nucleus
GOC:TermGenie
inhibition of protein localization to nucleus
GOC:TermGenie
Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.
bf
2012-03-12T01:23:52Z
activation of protein localization in nucleus
positive regulation of protein localisation to nucleus
positive regulation of protein localization in cell nucleus
positive regulation of protein localization in nucleus
up regulation of protein localisation to nucleus
up regulation of protein localization in cell nucleus
up regulation of protein localization in nucleus
up regulation of protein localization to nucleus
up-regulation of protein localisation to nucleus
up-regulation of protein localization in cell nucleus
up-regulation of protein localization in nucleus
up-regulation of protein localization to nucleus
upregulation of protein localisation to nucleus
upregulation of protein localization in cell nucleus
upregulation of protein localization in nucleus
upregulation of protein localization to nucleus
activation of protein localisation to nucleus
activation of protein localization in cell nucleus
activation of protein localization to nucleus
biological_process
GO:1900182
positive regulation of protein localization to nucleus
Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.
GOC:TermGenie
activation of protein localization in nucleus
GOC:TermGenie
positive regulation of protein localisation to nucleus
GOC:TermGenie
positive regulation of protein localization in cell nucleus
GOC:TermGenie
positive regulation of protein localization in nucleus
GOC:TermGenie
up regulation of protein localisation to nucleus
GOC:TermGenie
up regulation of protein localization in cell nucleus
GOC:TermGenie
up regulation of protein localization in nucleus
GOC:TermGenie
up regulation of protein localization to nucleus
GOC:TermGenie
up-regulation of protein localisation to nucleus
GOC:TermGenie
up-regulation of protein localization in cell nucleus
GOC:TermGenie
up-regulation of protein localization in nucleus
GOC:TermGenie
up-regulation of protein localization to nucleus
GOC:TermGenie
upregulation of protein localisation to nucleus
GOC:TermGenie
upregulation of protein localization in cell nucleus
GOC:TermGenie
upregulation of protein localization in nucleus
GOC:TermGenie
upregulation of protein localization to nucleus
GOC:TermGenie
activation of protein localisation to nucleus
GOC:TermGenie
activation of protein localization in cell nucleus
GOC:TermGenie
activation of protein localization to nucleus
GOC:TermGenie
The chemical reactions and pathways involving organic cyclic compound.
bf
2012-09-14T09:03:51Z
organic cyclic compound metabolism
biological_process
GO:1901360
organic cyclic compound metabolic process
The chemical reactions and pathways involving organic cyclic compound.
GOC:TermGenie
organic cyclic compound metabolism
GOC:TermGenie
The chemical reactions and pathways resulting in the breakdown of organic cyclic compound.
bf
2012-09-14T09:05:04Z
organic cyclic compound breakdown
organic cyclic compound catabolism
organic cyclic compound degradation
biological_process
GO:1901361
organic cyclic compound catabolic process
The chemical reactions and pathways resulting in the breakdown of organic cyclic compound.
GOC:TermGenie
organic cyclic compound breakdown
GOC:TermGenie
organic cyclic compound catabolism
GOC:TermGenie
organic cyclic compound degradation
GOC:TermGenie
The chemical reactions and pathways resulting in the formation of organic cyclic compound.
bf
2012-09-14T09:05:22Z
organic cyclic compound anabolism
organic cyclic compound biosynthesis
organic cyclic compound formation
organic cyclic compound synthesis
biological_process
GO:1901362
organic cyclic compound biosynthetic process
The chemical reactions and pathways resulting in the formation of organic cyclic compound.
GOC:TermGenie
organic cyclic compound anabolism
GOC:TermGenie
organic cyclic compound biosynthesis
GOC:TermGenie
organic cyclic compound formation
GOC:TermGenie
organic cyclic compound synthesis
GOC:TermGenie
Interacting selectively and non-covalently with heterocyclic compound.
bf
2012-09-14T13:53:50Z
molecular_function
GO:1901363
heterocyclic compound binding
Interacting selectively and non-covalently with heterocyclic compound.
GOC:TermGenie
The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon.
pr
2012-11-05T11:04:36Z
organic molecular entity breakdown
organic molecular entity catabolic process
organic molecular entity catabolism
organic molecular entity degradation
organic substance breakdown
organic substance catabolism
organic substance degradation
biological_process
GO:1901575
organic substance catabolic process
The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon.
GOC:TermGenie
GOC:pr
organic molecular entity breakdown
GOC:TermGenie
organic molecular entity catabolism
GOC:TermGenie
organic molecular entity degradation
GOC:TermGenie
The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon.
pr
2012-11-05T11:04:40Z
organic molecular entity anabolism
organic molecular entity biosynthesis
organic molecular entity biosynthetic process
organic molecular entity formation
organic molecular entity synthesis
organic substance anabolism
organic substance biosynthesis
organic substance formation
organic substance synthesis
biological_process
GO:1901576
organic substance biosynthetic process
The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon.
GOC:TermGenie
GOC:pr
organic molecular entity anabolism
GOC:TermGenie
organic molecular entity biosynthesis
GOC:TermGenie
organic molecular entity formation
GOC:TermGenie
organic molecular entity synthesis
GOC:TermGenie
Any process that modulates the frequency, rate or extent of intracellular signal transduction.
bf
2013-12-02T11:32:52Z
GO:0010627
regulation of intracellular signaling cascade
regulation of intracellular signaling chain
regulation of intracellular protein kinase cascade
regulation of intracellular signal transduction pathway
regulation of signal transmission via intracellular cascade
biological_process
regulation of intracellular signaling pathway
regulation of signal transduction via intracellular signaling cascade
GO:1902531
regulation of intracellular signal transduction
Any process that modulates the frequency, rate or extent of intracellular signal transduction.
GOC:TermGenie
GOC:dph
GOC:signaling
GOC:tb
regulation of intracellular signaling cascade
GOC:TermGenie
regulation of intracellular signaling chain
GOC:TermGenie
regulation of intracellular signal transduction pathway
GOC:TermGenie
regulation of signal transmission via intracellular cascade
GOC:TermGenie
regulation of intracellular signaling pathway
GOC:TermGenie
regulation of signal transduction via intracellular signaling cascade
GOC:TermGenie
Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction.
bf
2013-12-02T11:33:01Z
GO:0010741
down regulation of intracellular signal transduction
down regulation of intracellular signaling chain
down-regulation of intracellular signal transduction
down-regulation of intracellular signaling chain
downregulation of intracellular signal transduction
downregulation of intracellular signaling chain
negative regulation of intracellular protein kinase cascade
negative regulation of intracellular signaling cascade
negative regulation of intracellular signaling chain
down regulation of intracellular signal transduction pathway
down regulation of intracellular signaling cascade
down regulation of signal transmission via intracellular cascade
down-regulation of intracellular signal transduction pathway
downregulation of intracellular signal transduction pathway
downregulation of intracellular signaling cascade
downregulation of signal transmission via intracellular cascade
inhibition of intracellular signal transduction
inhibition of intracellular signal transduction pathway
inhibition of intracellular signaling cascade
inhibition of intracellular signaling chain
inhibition of signal transmission via intracellular cascade
negative regulation of intracellular signal transduction pathway
negative regulation of signal transmission via intracellular cascade
biological_process
down regulation of intracellular signaling pathway
down regulation of signal transduction via intracellular signaling cascade
down-regulation of intracellular signaling cascade
down-regulation of intracellular signaling pathway
down-regulation of signal transduction via intracellular signaling cascade
down-regulation of signal transmission via intracellular cascade
downregulation of intracellular signaling pathway
downregulation of signal transduction via intracellular signaling cascade
inhibition of intracellular signaling pathway
inhibition of signal transduction via intracellular signaling cascade
negative regulation of intracellular signaling pathway
negative regulation of signal transduction via intracellular signaling cascade
GO:1902532
negative regulation of intracellular signal transduction
Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction.
GOC:TermGenie
GOC:dph
GOC:signaling
GOC:tb
down regulation of intracellular signal transduction
GOC:TermGenie
down regulation of intracellular signaling chain
GOC:TermGenie
down-regulation of intracellular signal transduction
GOC:TermGenie
down-regulation of intracellular signaling chain
GOC:TermGenie
downregulation of intracellular signal transduction
GOC:TermGenie
downregulation of intracellular signaling chain
GOC:TermGenie
negative regulation of intracellular signaling cascade
GOC:TermGenie
negative regulation of intracellular signaling chain
GOC:TermGenie
down regulation of intracellular signal transduction pathway
GOC:TermGenie
down regulation of intracellular signaling cascade
GOC:TermGenie
down regulation of signal transmission via intracellular cascade
GOC:TermGenie
down-regulation of intracellular signal transduction pathway
GOC:TermGenie
downregulation of intracellular signal transduction pathway
GOC:TermGenie
downregulation of intracellular signaling cascade
GOC:TermGenie
downregulation of signal transmission via intracellular cascade
GOC:TermGenie
inhibition of intracellular signal transduction
GOC:TermGenie
inhibition of intracellular signal transduction pathway
GOC:TermGenie
inhibition of intracellular signaling cascade
GOC:TermGenie
inhibition of intracellular signaling chain
GOC:TermGenie
inhibition of signal transmission via intracellular cascade
GOC:TermGenie
negative regulation of intracellular signal transduction pathway
GOC:TermGenie
negative regulation of signal transmission via intracellular cascade
GOC:TermGenie
down regulation of intracellular signaling pathway
GOC:TermGenie
down regulation of signal transduction via intracellular signaling cascade
GOC:TermGenie
down-regulation of intracellular signaling cascade
GOC:TermGenie
down-regulation of intracellular signaling pathway
GOC:TermGenie
down-regulation of signal transduction via intracellular signaling cascade
GOC:TermGenie
down-regulation of signal transmission via intracellular cascade
GOC:TermGenie
downregulation of intracellular signaling pathway
GOC:TermGenie
downregulation of signal transduction via intracellular signaling cascade
GOC:TermGenie
inhibition of intracellular signaling pathway
GOC:TermGenie
inhibition of signal transduction via intracellular signaling cascade
GOC:TermGenie
negative regulation of intracellular signaling pathway
GOC:TermGenie
negative regulation of signal transduction via intracellular signaling cascade
GOC:TermGenie
Any process that activates or increases the frequency, rate or extent of intracellular signal transduction.
bf
2013-12-02T11:33:10Z
GO:0010740
positive regulation of intracellular signaling chain
up regulation of intracellular signal transduction
up regulation of intracellular signaling chain
up-regulation of intracellular signal transduction
up-regulation of intracellular signaling chain
upregulation of intracellular signal transduction
upregulation of intracellular signaling chain
activation of intracellular signal transduction
activation of intracellular signal transduction pathway
activation of intracellular signaling cascade
activation of intracellular signaling chain
activation of signal transmission via intracellular cascade
positive regulation of intracellular protein kinase cascade
positive regulation of intracellular signal transduction pathway
positive regulation of signal transmission via intracellular cascade
up regulation of intracellular signal transduction pathway
up regulation of signal transmission via intracellular cascade
up-regulation of intracellular signal transduction pathway
up-regulation of signal transmission via intracellular cascade
upregulation of intracellular signal transduction pathway
upregulation of signal transmission via intracellular cascade
biological_process
activation of intracellular signaling pathway
activation of signal transduction via intracellular signaling cascade
positive regulation of intracellular signaling cascade
positive regulation of intracellular signaling pathway
positive regulation of signal transduction via intracellular signaling cascade
up regulation of intracellular signaling cascade
up regulation of intracellular signaling pathway
up regulation of signal transduction via intracellular signaling cascade
up-regulation of intracellular signaling cascade
up-regulation of intracellular signaling pathway
up-regulation of signal transduction via intracellular signaling cascade
upregulation of intracellular signaling cascade
upregulation of intracellular signaling pathway
upregulation of signal transduction via intracellular signaling cascade
GO:1902533
positive regulation of intracellular signal transduction
Any process that activates or increases the frequency, rate or extent of intracellular signal transduction.
GOC:BHF
GOC:TermGenie
GOC:dph
GOC:signaling
GOC:tb
positive regulation of intracellular signaling chain
GOC:TermGenie
up regulation of intracellular signal transduction
GOC:TermGenie
up regulation of intracellular signaling chain
GOC:TermGenie
up-regulation of intracellular signal transduction
GOC:TermGenie
up-regulation of intracellular signaling chain
GOC:TermGenie
upregulation of intracellular signal transduction
GOC:TermGenie
upregulation of intracellular signaling chain
GOC:TermGenie
activation of intracellular signal transduction
GOC:TermGenie
activation of intracellular signal transduction pathway
GOC:TermGenie
activation of intracellular signaling cascade
GOC:TermGenie
activation of intracellular signaling chain
GOC:TermGenie
activation of signal transmission via intracellular cascade
GOC:TermGenie
positive regulation of intracellular signal transduction pathway
GOC:TermGenie
positive regulation of signal transmission via intracellular cascade
GOC:TermGenie
up regulation of intracellular signal transduction pathway
GOC:TermGenie
up regulation of signal transmission via intracellular cascade
GOC:TermGenie
up-regulation of intracellular signal transduction pathway
GOC:TermGenie
up-regulation of signal transmission via intracellular cascade
GOC:TermGenie
upregulation of intracellular signal transduction pathway
GOC:TermGenie
upregulation of signal transmission via intracellular cascade
GOC:TermGenie
activation of intracellular signaling pathway
GOC:TermGenie
activation of signal transduction via intracellular signaling cascade
GOC:TermGenie
positive regulation of intracellular signaling cascade
GOC:TermGenie
positive regulation of intracellular signaling pathway
GOC:TermGenie
positive regulation of signal transduction via intracellular signaling cascade
GOC:TermGenie
up regulation of intracellular signaling cascade
GOC:TermGenie
up regulation of intracellular signaling pathway
GOC:TermGenie
up regulation of signal transduction via intracellular signaling cascade
GOC:TermGenie
up-regulation of intracellular signaling cascade
GOC:TermGenie
up-regulation of intracellular signaling pathway
GOC:TermGenie
up-regulation of signal transduction via intracellular signaling cascade
GOC:TermGenie
upregulation of intracellular signaling cascade
GOC:TermGenie
upregulation of intracellular signaling pathway
GOC:TermGenie
upregulation of signal transduction via intracellular signaling cascade
GOC:TermGenie
A process in which a protein is transported to, or maintained in, a location within a nucleolus.
mah
2013-12-10T16:25:28Z
protein localisation in nucleolus
protein localisation to nucleolus
protein localization in nucleolus
biological_process
GO:1902570
protein localization to nucleolus
A process in which a protein is transported to, or maintained in, a location within a nucleolus.
GOC:TermGenie
PMID:22809626
protein localisation in nucleolus
GOC:TermGenie
protein localisation to nucleolus
GOC:TermGenie
protein localization in nucleolus
GOC:TermGenie
A localization which involves only one organism.
jl
2013-12-18T13:51:04Z
single organism localization
biological_process
GO:1902578
single-organism localization
A localization which involves only one organism.
GOC:jl
GO_REF:0000089
PMID:1234
single organism localization
GOC:TermGenie
A cellular localization which involves only one organism.
jl
2013-12-18T14:04:32Z
single organism cellular localization
biological_process
GO:1902580
single-organism cellular localization
A cellular localization which involves only one organism.
GOC:TermGenie
GOC:jl
GO_REF:0000089
single organism cellular localization
GOC:TermGenie
An intracellular transport which involves only one organism.
jl
2013-12-18T14:04:50Z
single organism intracellular transport
biological_process
GO:1902582
single-organism intracellular transport
An intracellular transport which involves only one organism.
GOC:TermGenie
GOC:jl
GO_REF:0000089
single organism intracellular transport
GOC:TermGenie
An organelle organization which involves only one organism.
jl
2013-12-19T15:25:51Z
single organism organelle organization
biological_process
GO:1902589
single-organism organelle organization
An organelle organization which involves only one organism.
GOC:TermGenie
GOC:jl
GO_REF:0000089
single organism organelle organization
GOC:TermGenie
A nuclear import which involves only one organism.
jl
2013-12-19T15:26:34Z
single organism nuclear import
biological_process
GO:1902593
single-organism nuclear import
A nuclear import which involves only one organism.
GOC:TermGenie
GOC:jl
GO_REF:0000089
single organism nuclear import
GOC:TermGenie
Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process.
jl
2014-02-05T16:32:01Z
down regulation of RNA anabolism
down regulation of RNA biosynthesis
down regulation of RNA biosynthetic process
down regulation of RNA formation
down regulation of RNA synthesis
down-regulation of RNA anabolism
down-regulation of RNA biosynthesis
down-regulation of RNA biosynthetic process
down-regulation of RNA formation
down-regulation of RNA synthesis
downregulation of RNA anabolism
downregulation of RNA biosynthesis
downregulation of RNA biosynthetic process
downregulation of RNA formation
downregulation of RNA synthesis
negative regulation of RNA anabolism
negative regulation of RNA biosynthesis
negative regulation of RNA formation
negative regulation of RNA synthesis
inhibition of RNA anabolism
inhibition of RNA biosynthesis
inhibition of RNA biosynthetic process
inhibition of RNA formation
inhibition of RNA synthesis
biological_process
GO:1902679
negative regulation of RNA biosynthetic process
Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process.
GO:jl
GOC:TermGenie
GO_REF:0000058
down regulation of RNA anabolism
GOC:TermGenie
down regulation of RNA biosynthesis
GOC:TermGenie
down regulation of RNA biosynthetic process
GOC:TermGenie
down regulation of RNA formation
GOC:TermGenie
down regulation of RNA synthesis
GOC:TermGenie
down-regulation of RNA anabolism
GOC:TermGenie
down-regulation of RNA biosynthesis
GOC:TermGenie
down-regulation of RNA biosynthetic process
GOC:TermGenie
down-regulation of RNA formation
GOC:TermGenie
down-regulation of RNA synthesis
GOC:TermGenie
downregulation of RNA anabolism
GOC:TermGenie
downregulation of RNA biosynthesis
GOC:TermGenie
downregulation of RNA biosynthetic process
GOC:TermGenie
downregulation of RNA formation
GOC:TermGenie
downregulation of RNA synthesis
GOC:TermGenie
negative regulation of RNA anabolism
GOC:TermGenie
negative regulation of RNA biosynthesis
GOC:TermGenie
negative regulation of RNA formation
GOC:TermGenie
negative regulation of RNA synthesis
GOC:TermGenie
inhibition of RNA anabolism
GOC:TermGenie
inhibition of RNA biosynthesis
GOC:TermGenie
inhibition of RNA biosynthetic process
GOC:TermGenie
inhibition of RNA formation
GOC:TermGenie
inhibition of RNA synthesis
GOC:TermGenie
Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process.
jl
2014-02-05T16:32:10Z
positive regulation of RNA anabolism
positive regulation of RNA biosynthesis
positive regulation of RNA formation
positive regulation of RNA synthesis
up regulation of RNA anabolism
up regulation of RNA biosynthesis
up regulation of RNA biosynthetic process
up regulation of RNA formation
up regulation of RNA synthesis
up-regulation of RNA anabolism
up-regulation of RNA biosynthesis
up-regulation of RNA biosynthetic process
up-regulation of RNA formation
up-regulation of RNA synthesis
upregulation of RNA anabolism
upregulation of RNA biosynthesis
upregulation of RNA biosynthetic process
upregulation of RNA formation
upregulation of RNA synthesis
activation of RNA anabolism
activation of RNA biosynthesis
activation of RNA biosynthetic process
activation of RNA formation
activation of RNA synthesis
biological_process
GO:1902680
positive regulation of RNA biosynthetic process
Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process.
GO:jl
GOC:TermGenie
GO_REF:0000058
positive regulation of RNA anabolism
GOC:TermGenie
positive regulation of RNA biosynthesis
GOC:TermGenie
positive regulation of RNA formation
GOC:TermGenie
positive regulation of RNA synthesis
GOC:TermGenie
up regulation of RNA anabolism
GOC:TermGenie
up regulation of RNA biosynthesis
GOC:TermGenie
up regulation of RNA biosynthetic process
GOC:TermGenie
up regulation of RNA formation
GOC:TermGenie
up regulation of RNA synthesis
GOC:TermGenie
up-regulation of RNA anabolism
GOC:TermGenie
up-regulation of RNA biosynthesis
GOC:TermGenie
up-regulation of RNA biosynthetic process
GOC:TermGenie
up-regulation of RNA formation
GOC:TermGenie
up-regulation of RNA synthesis
GOC:TermGenie
upregulation of RNA anabolism
GOC:TermGenie
upregulation of RNA biosynthesis
GOC:TermGenie
upregulation of RNA biosynthetic process
GOC:TermGenie
upregulation of RNA formation
GOC:TermGenie
upregulation of RNA synthesis
GOC:TermGenie
activation of RNA anabolism
GOC:TermGenie
activation of RNA biosynthesis
GOC:TermGenie
activation of RNA biosynthetic process
GOC:TermGenie
activation of RNA formation
GOC:TermGenie
activation of RNA synthesis
GOC:TermGenie
A process that is part of the mitotic cell cycle.
jl
2014-05-22T14:22:34Z
biological_process
GO:1903047
mitotic cell cycle process
A process that is part of the mitotic cell cycle.
GOC:TermGenie
GOC:mtg_cell_cycle
GO_REF:0000060
A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton.
mah
2014-06-16T11:27:09Z
protein localisation in actin cytoskeleton
protein localisation to actin cytoskeleton
protein localization in actin cytoskeleton
biological_process
GO:1903119
protein localization to actin cytoskeleton
A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton.
GOC:TermGenie
GO_REF:0000087
PMID:24798735
protein localisation in actin cytoskeleton
GOC:TermGenie
protein localisation to actin cytoskeleton
GOC:TermGenie
protein localization in actin cytoskeleton
GOC:TermGenie
A process in which a protein is transported to, or maintained in, the location of an actin filament bundle.
mah
2014-06-16T11:27:16Z
protein localisation in actin filament bundle
protein localisation to actin filament bundle
protein localization in actin filament bundle
biological_process
protein localization to actin cable
GO:1903120
protein localization to actin filament bundle
A process in which a protein is transported to, or maintained in, the location of an actin filament bundle.
GOC:TermGenie
GO_REF:0000087
PMID:24798735
protein localisation in actin filament bundle
GOC:TermGenie
protein localisation to actin filament bundle
GOC:TermGenie
protein localization in actin filament bundle
GOC:TermGenie
protein localization to actin cable
GOC:mah
A process in which a protein is transported to, or maintained in, a location within a nuclear body.
mah
2014-09-01T13:57:11Z
protein localisation in nuclear body
protein localisation to nuclear body
protein localization in nuclear body
biological_process
GO:1903405
protein localization to nuclear body
A process in which a protein is transported to, or maintained in, a location within a nuclear body.
GOC:TermGenie
GO_REF:0000087
PMID:24713849
protein localisation in nuclear body
GOC:TermGenie
protein localisation to nuclear body
GOC:TermGenie
protein localization in nuclear body
GOC:TermGenie
Any process that modulates the frequency, rate or extent of nucleic acid-templated transcription.
pr
2014-10-01T14:44:47Z
biological_process
GO:1903506
regulation of nucleic acid-templated transcription
Any process that modulates the frequency, rate or extent of nucleic acid-templated transcription.
GOC:TermGenie
GOC:pr
GOC:txnOH
GOC:vw
GO_REF:0000058
Any process that stops, prevents or reduces the frequency, rate or extent of nucleic acid-templated transcription.
pr
2014-10-01T14:44:56Z
down regulation of nucleic acid-templated transcription
down-regulation of nucleic acid-templated transcription
downregulation of nucleic acid-templated transcription
inhibition of nucleic acid-templated transcription
biological_process
GO:1903507
negative regulation of nucleic acid-templated transcription
Any process that stops, prevents or reduces the frequency, rate or extent of nucleic acid-templated transcription.
GOC:TermGenie
GOC:pr
GOC:txnOH
GOC:vw
GO_REF:0000058
down regulation of nucleic acid-templated transcription
GOC:TermGenie
down-regulation of nucleic acid-templated transcription
GOC:TermGenie
downregulation of nucleic acid-templated transcription
GOC:TermGenie
inhibition of nucleic acid-templated transcription
GOC:TermGenie
Any process that activates or increases the frequency, rate or extent of nucleic acid-templated transcription.
pr
2014-10-01T14:45:04Z
up regulation of nucleic acid-templated transcription
up-regulation of nucleic acid-templated transcription
upregulation of nucleic acid-templated transcription
activation of nucleic acid-templated transcription
biological_process
GO:1903508
positive regulation of nucleic acid-templated transcription
Any process that activates or increases the frequency, rate or extent of nucleic acid-templated transcription.
GOC:TermGenie
GOC:pr
GOC:txnOH
GOC:vw
GO_REF:0000058
up regulation of nucleic acid-templated transcription
GOC:TermGenie
up-regulation of nucleic acid-templated transcription
GOC:TermGenie
upregulation of nucleic acid-templated transcription
GOC:TermGenie
activation of nucleic acid-templated transcription
GOC:TermGenie
Any process that modulates the frequency, rate or extent of protein targeting.
al
2014-10-08T14:49:03Z
regulation of protein sorting along secretory pathway
biological_process
regulation of nascent polypeptide association
GO:1903533
regulation of protein targeting
Any process that modulates the frequency, rate or extent of protein targeting.
GOC:TermGenie
GO_REF:0000058
regulation of protein sorting along secretory pathway
GOC:TermGenie
regulation of nascent polypeptide association
GOC:TermGenie
Any process that modulates the frequency, rate or extent of cytoplasmic transport.
jl
2014-11-24T13:38:17Z
regulation of cytoplasmic streaming
biological_process
GO:1903649
regulation of cytoplasmic transport
Any process that modulates the frequency, rate or extent of cytoplasmic transport.
GOC:TermGenie
GO_REF:0000058
PMID:25049409
regulation of cytoplasmic streaming
GOC:TermGenie
Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic transport.
jl
2014-11-24T13:38:26Z
down regulation of cytoplasmic transport
down-regulation of cytoplasmic transport
downregulation of cytoplasmic transport
down regulation of cytoplasmic streaming
down-regulation of cytoplasmic streaming
downregulation of cytoplasmic streaming
inhibition of cytoplasmic streaming
inhibition of cytoplasmic transport
negative regulation of cytoplasmic streaming
biological_process
GO:1903650
negative regulation of cytoplasmic transport
Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic transport.
GOC:TermGenie
GO_REF:0000058
PMID:25049409
down regulation of cytoplasmic transport
GOC:TermGenie
down-regulation of cytoplasmic transport
GOC:TermGenie
downregulation of cytoplasmic transport
GOC:TermGenie
down regulation of cytoplasmic streaming
GOC:TermGenie
down-regulation of cytoplasmic streaming
GOC:TermGenie
downregulation of cytoplasmic streaming
GOC:TermGenie
inhibition of cytoplasmic streaming
GOC:TermGenie
inhibition of cytoplasmic transport
GOC:TermGenie
negative regulation of cytoplasmic streaming
GOC:TermGenie
Any process that activates or increases the frequency, rate or extent of cytoplasmic transport.
jl
2014-11-24T13:38:34Z
up regulation of cytoplasmic transport
up-regulation of cytoplasmic transport
upregulation of cytoplasmic transport
activation of cytoplasmic streaming
activation of cytoplasmic transport
positive regulation of cytoplasmic streaming
up regulation of cytoplasmic streaming
up-regulation of cytoplasmic streaming
upregulation of cytoplasmic streaming
biological_process
GO:1903651
positive regulation of cytoplasmic transport
Any process that activates or increases the frequency, rate or extent of cytoplasmic transport.
GOC:TermGenie
GO_REF:0000058
PMID:25049409
up regulation of cytoplasmic transport
GOC:TermGenie
up-regulation of cytoplasmic transport
GOC:TermGenie
upregulation of cytoplasmic transport
GOC:TermGenie
activation of cytoplasmic streaming
GOC:TermGenie
activation of cytoplasmic transport
GOC:TermGenie
positive regulation of cytoplasmic streaming
GOC:TermGenie
up regulation of cytoplasmic streaming
GOC:TermGenie
up-regulation of cytoplasmic streaming
GOC:TermGenie
upregulation of cytoplasmic streaming
GOC:TermGenie
A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane.
mah
2015-01-07T13:15:54Z
protein localisation in vacuolar membrane
protein localisation to vacuolar membrane
protein localization in vacuolar membrane
biological_process
GO:1903778
protein localization to vacuolar membrane
A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane.
GOC:TermGenie
GO_REF:0000087
PMID:25378562
protein localisation in vacuolar membrane
GOC:TermGenie
protein localisation to vacuolar membrane
GOC:TermGenie
protein localization in vacuolar membrane
GOC:TermGenie
Any process that modulates the frequency, rate or extent of cellular protein localization.
jl
2015-01-20T14:32:14Z
regulation of cellular protein localisation
regulation of channel localizer activity
biological_process
GO:1903827
regulation of cellular protein localization
Any process that modulates the frequency, rate or extent of cellular protein localization.
GOC:TermGenie
GOC:vw
GO_REF:0000058
regulation of cellular protein localisation
GOC:TermGenie
regulation of channel localizer activity
GOC:TermGenie
Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein localization.
jl
2015-01-20T14:32:24Z
down regulation of cellular protein localisation
down regulation of cellular protein localization
down-regulation of cellular protein localisation
down-regulation of cellular protein localization
downregulation of cellular protein localisation
downregulation of cellular protein localization
negative regulation of cellular protein localisation
down regulation of channel localizer activity
down-regulation of channel localizer activity
downregulation of channel localizer activity
inhibition of cellular protein localisation
inhibition of cellular protein localization
inhibition of channel localizer activity
negative regulation of channel localizer activity
biological_process
GO:1903828
negative regulation of cellular protein localization
Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein localization.
GOC:TermGenie
GOC:vw
GO_REF:0000058
down regulation of cellular protein localisation
GOC:TermGenie
down regulation of cellular protein localization
GOC:TermGenie
down-regulation of cellular protein localisation
GOC:TermGenie
down-regulation of cellular protein localization
GOC:TermGenie
downregulation of cellular protein localisation
GOC:TermGenie
downregulation of cellular protein localization
GOC:TermGenie
negative regulation of cellular protein localisation
GOC:TermGenie
down regulation of channel localizer activity
GOC:TermGenie
down-regulation of channel localizer activity
GOC:TermGenie
downregulation of channel localizer activity
GOC:TermGenie
inhibition of cellular protein localisation
GOC:TermGenie
inhibition of cellular protein localization
GOC:TermGenie
inhibition of channel localizer activity
GOC:TermGenie
negative regulation of channel localizer activity
GOC:TermGenie
Any process that activates or increases the frequency, rate or extent of cellular protein localization.
jl
2015-01-20T14:32:33Z
positive regulation of cellular protein localisation
up regulation of cellular protein localisation
up regulation of cellular protein localization
up-regulation of cellular protein localisation
up-regulation of cellular protein localization
upregulation of cellular protein localisation
upregulation of cellular protein localization
activation of cellular protein localisation
activation of cellular protein localization
activation of channel localizer activity
positive regulation of channel localizer activity
up regulation of channel localizer activity
up-regulation of channel localizer activity
upregulation of channel localizer activity
biological_process
GO:1903829
positive regulation of cellular protein localization
Any process that activates or increases the frequency, rate or extent of cellular protein localization.
GOC:TermGenie
GOC:vw
GO_REF:0000058
positive regulation of cellular protein localisation
GOC:TermGenie
up regulation of cellular protein localisation
GOC:TermGenie
up regulation of cellular protein localization
GOC:TermGenie
up-regulation of cellular protein localisation
GOC:TermGenie
up-regulation of cellular protein localization
GOC:TermGenie
upregulation of cellular protein localisation
GOC:TermGenie
upregulation of cellular protein localization
GOC:TermGenie
activation of cellular protein localisation
GOC:TermGenie
activation of cellular protein localization
GOC:TermGenie
activation of channel localizer activity
GOC:TermGenie
positive regulation of channel localizer activity
GOC:TermGenie
up regulation of channel localizer activity
GOC:TermGenie
up-regulation of channel localizer activity
GOC:TermGenie
upregulation of channel localizer activity
GOC:TermGenie
A process in which a protein is transported to, or maintained in, a location within the nuclear periphery.
mah
2013-07-09T13:35:49Z
biological_process
GO:1990139
protein localization to nuclear periphery
A process in which a protein is transported to, or maintained in, a location within the nuclear periphery.
GOC:mah
PMID:23703609
A process in which a protein is transported to, or maintained in, a location within the nucleoplasm.
mah
2013-08-23T15:01:16Z
protein localisation to nucleoplasm
biological_process
GO:1990173
protein localization to nucleoplasm
A process in which a protein is transported to, or maintained in, a location within the nucleoplasm.
GOC:mah
PMID:22918952
protein localisation to nucleoplasm
GOC:mah
Any process that modulates the frequency, rate or extent of cellular macromolecule biosynthetic process.
tanyaberardini
2010-09-15T08:55:45Z
regulation of cellular biopolymer biosynthetic process
regulation of cellular macromolecule anabolism
regulation of cellular macromolecule biosynthesis
regulation of cellular macromolecule formation
regulation of cellular macromolecule synthesis
biological_process
GO:2000112
regulation of cellular macromolecule biosynthetic process
Any process that modulates the frequency, rate or extent of cellular macromolecule biosynthetic process.
GOC:obol
regulation of cellular biopolymer biosynthetic process
GOC:obol
regulation of cellular macromolecule anabolism
GOC:obol
regulation of cellular macromolecule biosynthesis
GOC:obol
regulation of cellular macromolecule formation
GOC:obol
regulation of cellular macromolecule synthesis
GOC:obol
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process.
tanyaberardini
2010-09-15T08:55:48Z
negative regulation of cellular biopolymer biosynthetic process
negative regulation of cellular macromolecule anabolism
negative regulation of cellular macromolecule biosynthesis
negative regulation of cellular macromolecule formation
negative regulation of cellular macromolecule synthesis
biological_process
GO:2000113
negative regulation of cellular macromolecule biosynthetic process
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process.
GOC:obol
negative regulation of cellular biopolymer biosynthetic process
GOC:obol
negative regulation of cellular macromolecule anabolism
GOC:obol
negative regulation of cellular macromolecule biosynthesis
GOC:obol
negative regulation of cellular macromolecule formation
GOC:obol
negative regulation of cellular macromolecule synthesis
GOC:obol
Any process that modulates the frequency, rate or extent of RNA biosynthetic process.
dph
2011-10-17T11:36:25Z
regulation of RNA anabolism
regulation of RNA biosynthesis
regulation of RNA formation
regulation of RNA synthesis
biological_process
GO:2001141
regulation of RNA biosynthetic process
Any process that modulates the frequency, rate or extent of RNA biosynthetic process.
GOC:dph
regulation of RNA anabolism
GOC:obol
regulation of RNA biosynthesis
GOC:obol
regulation of RNA formation
GOC:obol
regulation of RNA synthesis
GOC:obol
A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities.
PATO:0000072
trait
quality
PATO:0000001
quality
A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities.
PATOC:GVG
A physical quality inhering in a bearer by virtue of the bearer's scalar absolute value of the rate of change of the bearer's position.
quality
velocity
PATO:0000008
speed
A physical quality inhering in a bearer by virtue of the bearer's scalar absolute value of the rate of change of the bearer's position.
Wikipedia:http://en.wikipedia.org/wiki/Velocity
A scalar optical property that is the intensity, value or amount of perceived light.
color intensity
color lightness
color value
quality
PATO:0000016
Color brightness refers to the intensity, lightness or value of the light present. Think of this as a dimmer switch.
color brightness
A scalar optical property that is the intensity, value or amount of perceived light.
PATOC:MAH
A quality inhering in a substance by virtue of the amount of the bearer's there is mixed with another substance.
concentration
quality
PATO:0000033
concentration of
A quality inhering in a substance by virtue of the amount of the bearer's there is mixed with another substance.
Wikipedia:http://en.wikipedia.org/wiki/concentration
A physical quality which inheres in a bearer by virtue of the number of the bearer's repetitive actions in a particular time.
quality
PATO:0000044
frequency
A physical quality which inheres in a bearer by virtue of the number of the bearer's repetitive actions in a particular time.
Wikipedia:http://en.wikipedia.org/wiki/frequency
A quality inhering in a bearer by virtue of the bearer's possessing or displaying a distinctive feature in type or degree or effect or force.
quality
PATO:0000049
intensity
A quality inhering in a bearer by virtue of the bearer's possessing or displaying a distinctive feature in type or degree or effect or force.
PATOC:GVG
A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure.
quality
PATO:0000051
morphology
A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure.
PATOC:GVG
A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc).
PATO:0001647
relational shape quality
quality
PATO:0000052
Shapes are invariant on size transformations. Shapes can be subdivided into 2D and 3D shapes, We can also make a distinction between shapes of complete self-connected objects, and shapes of parts of objects.
shape
A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc).
PATOC:GVG
A quality of a single process inhering in a bearer by virtue of the bearer's occurrence.
PATO:0000156
PATO:0000158
incidence
temporal
quality
PATO:0000057
occurrence quality
A quality of a single process inhering in a bearer by virtue of the bearer's occurrence.
PATOC:GVG
A spatial quality inhering in a bearer by virtue of the bearer's exhibiting repetition of placement of its parts.
PATO:0000132
PATO:0001565
distribution
quality
pattern
PATO:0000060
spatial pattern
A spatial quality inhering in a bearer by virtue of the bearer's exhibiting repetition of placement of its parts.
PATOC:GVG
quality
PATO:0000068
TODO: define this or obsolete it and move children somewhere else.
qualitative
A quality inhering in a bearer by virtue of the whether the bearer differs from normal or average.
quality
PATO:0000069
deviation(from_normal)
A quality inhering in a bearer by virtue of the whether the bearer differs from normal or average.
PATOC:GVG
A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude.
quality
PATO:0000117
size
A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude.
WordNet:WordNet
A 1-D extent quality which is equal to the distance between two points.
quality
PATO:0000122
length
A 1-D extent quality which is equal to the distance between two points.
PATOC:GVG
A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.
quality
PATO:0000125
mass
A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.
PATOC:GVG
A spatial quality inhering in a bearer by virtue of the bearer's spatial location relative to other objects in the vicinity.
PATO:0001032
PATO:0001631
location
placement
relational spatial quality
quality
PATO:0000140
position
A spatial quality inhering in a bearer by virtue of the bearer's spatial location relative to other objects in the vicinity.
PATOC:GVG
A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form.
PATO:0001452
relational structural quality
quality
PATO:0000141
structure
A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form.
PATOC:GVG
A quality of a single process inhering in a bearer by virtue of the bearer's occurrence per unit time.
quality
PATO:0000161
rate
A quality of a single process inhering in a bearer by virtue of the bearer's occurrence per unit time.
PATOC:melissa
An organismal quality inhering in a bearer or a population by virtue of the bearer's disposition to survive and develop normally or the number of surviving individuals in a given population.
quality
PATO:0000169
viability
An organismal quality inhering in a bearer or a population by virtue of the bearer's disposition to survive and develop normally or the number of surviving individuals in a given population.
PATOC:GVG
A quality of a process which ends earlier than the natural end time or reference process.
PATO:0001508
abolished
quality
incomplete
PATO:0000297
TODO: the definition is incorrect. See absent.
arrested
A quality of a process which ends earlier than the natural end time or reference process.
PATOC:LC
A speed which is relatively high.
high speed
quality
fast speed
PATO:0000303
increased speed
A speed which is relatively high.
PATOC:GVG
A speed which is relatively low.
slow
slow speed
quality
PATO:0000304
decreased speed
A speed which is relatively low.
PATOC:GVG
A spatial pattern inhering in a bearer by virtue of the bearer's magnitude of or the relationships between its repeated parts lack consistency.
quality
PATO:0000330
irregular spatial pattern
A spatial pattern inhering in a bearer by virtue of the bearer's magnitude of or the relationships between its repeated parts lack consistency.
PATOC:GVG
A frequency which is relatively high.
high frequency
quality
frequent
PATO:0000380
increased frequency
A frequency which is relatively high.
PATOC:GVG
A frequency which is relatively low.
low frequency
quality
infrequent
PATO:0000381
decreased frequency
A frequency which is relatively low.
PATOC:GVG
An intensity which is less than moderate in type or degree or effect or force.
quality
PATO:0000394
mild
An intensity which is less than moderate in type or degree or effect or force.
PATOC:GVG
An intensity which is extremely bad or unpleasant in type or degree or effect or force.
quality
PATO:0000396
severe
An intensity which is extremely bad or unpleasant in type or degree or effect or force.
WordNet:WordNet
A curvature quality inhering in a bearer by virtue of the bearer's having or being marked by a curve or smoothly rounded bend.
bowing
quality
curled
PATO:0000406
curved
A curvature quality inhering in a bearer by virtue of the bearer's having or being marked by a curve or smoothly rounded bend.
WordNet:WordNet
A shape quality inhering in a bearer by virtue of the bearer's being such that every part of the surface or the circumference is equidistant from the center.
quality
round
rounded
PATO:0000411
circular
A shape quality inhering in a bearer by virtue of the bearer's being such that every part of the surface or the circumference is equidistant from the center.
thefreedictionary.com:thefreedictionary.com
A pattern quality inhering in a bearer by virtue of the bearer's having a repeatable or predictable placement.
quality
PATO:0000440
regular spatial pattern
A pattern quality inhering in a bearer by virtue of the bearer's having a repeatable or predictable placement.
PATOC:GVG
A quality inhering in a bearer by virtue of the bearer's deviation from normal or average.
quality
aberrant
atypia
atypical
defective
PATO:0000460
abnormal
A quality inhering in a bearer by virtue of the bearer's deviation from normal or average.
PATOC:GVG
A quality inhering in a bearer by virtue of the bearer's exhibiting no deviation from normal or average.
quality
average
PATO:0000461
normal
A quality inhering in a bearer by virtue of the bearer's exhibiting no deviation from normal or average.
PATOC:GVG
A duration quality of a process which is relatively high.
PATO:0000715
high time
increased period
increased time
quality
chronic
prolonged period
slow time
PATO:0000498
increased duration
A duration quality of a process which is relatively high.
PATOC:GVG
A duration quality of a process which is relatively low.
PATO:0000716
decreased period
decreased time
low period
shortened period
quality
fast time
PATO:0000499
decreased duration
A duration quality of a process which is relatively low.
PATOC:GVG
A quality of a process which starts later than the natural start time or the reference process.
quality
late
PATO:0000502
delayed
A quality of a process which starts later than the natural start time or the reference process.
PATOC:LC
A length quality which is relatively large.
long
quality
PATO:0000573
increased length
A length quality which is relatively large.
PATOC:GVG
A length quality which is relatively small.
short
quality
shortened
stubby
PATO:0000574
decreased length
A length quality which is relatively small.
PATOC:GVG
A size quality which is relatively high.
PATO:0001202
quality
big
enlarged
expanded
great
large
PATO:0000586
increased size
A size quality which is relatively high.
PATOC:GVG
A size quality which is relatively low.
hypoplasia
underdeveloped
quality
small
tiny
PATO:0000587
decreased size
A size quality which is relatively low.
PATOC:GVG
A thickness which is relatively high.
high thickness
stout
thickened
quality
thick
PATO:0000591
increased thickness
A thickness which is relatively high.
PATOC:GVG
A thickness which is relatively low.
low thickness
quality
slender
thin
PATO:0000592
decreased thickness
A thickness which is relatively low.
PATOC:GVG
A volume which is relatively high.
high volume
quality
large volume
PATO:0000595
increased volume
A volume which is relatively high.
PATOC:GVG
A volume which is relatively low.
low volume
quality
small volume
PATO:0000596
decreased volume
A volume which is relatively low.
PATOC:GVG
A width which is relatively small.
quality
narrow
PATO:0000599
decreased width
A width which is relatively small.
PATOC:GVG
A width which is relatively large.
quality
broad
wide
wide/broad
PATO:0000600
increased width
A width which is relatively large.
PATOC:GVG
A symmetry quality inhering in a bearer by virtue of the bearer's lacking symmetry.
asymmetric
asymmetry
quality
PATO:0000616
asymmetrical
A symmetry quality inhering in a bearer by virtue of the bearer's lacking symmetry.
PATOC:GVG
A positional quality inhering in a bearer by virtue of the bearer's having two sides; two-sided.
quality
PATO:0000618
bilateral
A positional quality inhering in a bearer by virtue of the bearer's having two sides; two-sided.
thefreedictionary.com:thefreedictionary.com
A structural quality inhering in a bearer by virtue of the bearer's consisting of blebbing of the nucleus and DNA fragmentation due to the cell undergoing a specific form of programmed cell death termed apoptosis.
GO:0006915
quality
PATO:0000638
apoptotic
A structural quality inhering in a bearer by virtue of the bearer's consisting of blebbing of the nucleus and DNA fragmentation due to the cell undergoing a specific form of programmed cell death termed apoptosis.
PATOC:GVG
A color brightness which is relatively high.
light
quality
PATO:0000665
high brightness
A color brightness which is relatively high.
PATOC:MAH
A quality of a single process inhering in a bearer by virtue of the bearer's being uninterrupted in time, sequence, substance, or extent.
PATO:0000429
uninterrupted
quality
PATO:0000689
continuous
A quality of a single process inhering in a bearer by virtue of the bearer's being uninterrupted in time, sequence, substance, or extent.
thefreedictionary.com:thefreedictionary.com
A viability quality inhering in a population by virtue of the bearer's long term survival inability.
quality
PATO:0000718
lethal (sensu genetics)
A viability quality inhering in a population by virtue of the bearer's long term survival inability.
PATOC:GVG
A viability quality inhering in a bearer or a population by virtue of the bearer's ability to survive or the long term survival ability of a given population.
quality
PATO:0000719
viable
A viability quality inhering in a bearer or a population by virtue of the bearer's ability to survive or the long term survival ability of a given population.
PATOC:GVG
A rate which is relatively low.
slow rate
quality
PATO:0000911
decreased rate
A rate which is relatively low.
PATO:GVG
A rate which is relatively high.
fast rate
high rate
quality
PATO:0000912
increased rate
A rate which is relatively high.
PATO:GVG
A 1-D extent quality which is equal to the dimension through an object as opposed to its length or width.
quality
PATO:0000915
thickness
A 1-D extent quality which is equal to the dimension through an object as opposed to its length or width.
WordNet:WordNet
A 3-D extent quality inhering in a bearer by virtue of the bearer's amount of 3-dimensional space it occupies.
quality
PATO:0000918
volume
A 3-D extent quality inhering in a bearer by virtue of the bearer's amount of 3-dimensional space it occupies.
PATOC:GVG
A 1-D extent quality which is equal to the distance from one side of an object to another side which is opposite.
quality
breadth
PATO:0000921
This term is for curator easiness - we might consider obsoleting this but we have to consider how curators are going to represent them if we do.
width
A 1-D extent quality which is equal to the distance from one side of an object to another side which is opposite.
PATOC:GVG
A structural quality inhering in a bearer by virtue of the bearer's lacking organisation.
quality
PATO:0000937
disorganized
A structural quality inhering in a bearer by virtue of the bearer's lacking organisation.
PATOC:GVG
A shape quality inhering in a bearer by virtue of the bearer's having a sharp or tapered end or point.
apiculate
quality
PATO:0000944
sharpness
A shape quality inhering in a bearer by virtue of the bearer's having a sharp or tapered end or point.
PATOC:GVG
A spheroid quality inhering in a bearer by virtue of the bearer's being oval with two axes of symmetry, as produced by a conical section.
ellipse-shaped
ellipsoid
elliptical
quality
oval
ovoid
PATO:0000947
elliptic
A spheroid quality inhering in a bearer by virtue of the bearer's being oval with two axes of symmetry, as produced by a conical section.
PATOC:GVG
A pattern quality of inhering in a bearer by virtue of the correspondence in size, shape, and relative position of the bearer's parts on opposite sides of a dividing line or median plane or about a center or axis.
quality
PATO:0000965
symmetry
A pattern quality of inhering in a bearer by virtue of the correspondence in size, shape, and relative position of the bearer's parts on opposite sides of a dividing line or median plane or about a center or axis.
PATOC:GVG
A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities.
PATO:0002079
Wikipedia:Physical_property
relational physical quality
quality
PATO:0001018
physical quality
A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities.
PATOC:GVG
A quality inhering in a bearer by virtue of the bearer's length being notably higher than its width.
quality
PATO:0001154
elongated
A quality inhering in a bearer by virtue of the bearer's length being notably higher than its width.
WordNet:WordNet
A concentration quality inhering in a bearer by virtue of the bearer's exhibiting concentration.
quality
PATO:0001159
concentrated
A concentration quality inhering in a bearer by virtue of the bearer's exhibiting concentration.
PATOC:GVG
A concentration which is higher relative to the normal or average.
high concentration
quality
PATO:0001162
increased concentration
A concentration which is higher relative to the normal or average.
PATOC:GVG
A concentration which is lower relative to the normal or average.
low concentration
quality
PATO:0001163
decreased concentration
A concentration which is lower relative to the normal or average.
PATOC:GVG
A quality which inheres in an process.
PATO:0001239
PATO:0001240
quality of a process
quality of occurrent
quality of process
relational quality of occurrent
quality
PATO:0001236
See comments of relational quality of a physical entity.
process quality
A quality which inheres in an process.
PATOC:GVG
A quality which inheres in a continuant.
PATO:0001237
PATO:0001238
snap:Quality
monadic quality of a continuant
multiply inhering quality of a physical entity
quality of a continuant
quality of a single physical entity
quality of an object
quality of continuant
monadic quality of an object
monadic quality of continuant
quality
PATO:0001241
Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles.
physical object quality
A quality which inheres in a continuant.
PATOC:GVG
A physical quality that inheres in an bearer by virtue of how that bearer interacts with electromagnetic radiation.
quality
PATO:0001291
electromagnetic (EM) radiation quality
A physical quality that inheres in an bearer by virtue of how that bearer interacts with electromagnetic radiation.
Wikipedia:http://en.wikipedia.org/wiki/Electromagnetic_radiation
An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light.
quality
PATO:0001300
optical quality
An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light.
PATOC:GVG
A quality inhering in a bearer by virtue of the bearer's disposition to varying or changing.
quality
variability of a physical quality
PATO:0001303
variability
A quality inhering in a bearer by virtue of the bearer's disposition to varying or changing.
Dictionary:http://dictionary.reference.com/
A process quality inhering in a bearer by virtue of the bearer's magnitude of the temporal extent between the starting and ending point.
PATO:0000081
period
quality
time
PATO:0001309
duration quality of a process
A process quality inhering in a bearer by virtue of the bearer's magnitude of the temporal extent between the starting and ending point.
PATOC:mellybelly
A 2-D extent quality inhering in a bearer by virtue of the bearer's two dimensional extent.
quality
PATO:0001323
area
A 2-D extent quality inhering in a bearer by virtue of the bearer's two dimensional extent.
Wikipedia:http://en.wikipedia.org/wiki/Area
A symmetry quality inhering in a bearer by virtue of the bearer's having equal proportion around a central point or axis.
quality
PATO:0001325
radial symmetry
A symmetry quality inhering in a bearer by virtue of the bearer's having equal proportion around a central point or axis.
PATOC:GVG
A surface feature shape quality inhering in a bearer by virtue of the bearer's having spines, thorns or similar thin projections on its surface.
quality
PATO:0001365
spiny
A surface feature shape quality inhering in a bearer by virtue of the bearer's having spines, thorns or similar thin projections on its surface.
PATOC:GVG
A cellular quality inhering in a bearer by virtue of the bearer's number of homologous sets of chromosomes in the nucleus or primary chromosome-containing compartment of the cell, each set essentially coding for all the biological traits of the organism.
quality
PATO:0001374
ploidy
A cellular quality inhering in a bearer by virtue of the bearer's number of homologous sets of chromosomes in the nucleus or primary chromosome-containing compartment of the cell, each set essentially coding for all the biological traits of the organism.
Wikipedia:http://en.wikipedia.org/wiki/Ploidy
A ploidy quality inhering in a bearer by virtue of the bearer's containing more than two homologous sets of chromosomes.
quality
PATO:0001377
polyploid
A ploidy quality inhering in a bearer by virtue of the bearer's containing more than two homologous sets of chromosomes.
Wikipedia:http://en.wikipedia.org/wiki/Polyploid
A ploidy quality inhering in a bearer by virtue of the bearer's containing an integral multiple of the monoploid number, possibly excluding the sex-determining chromosomes.
quality
PATO:0001393
euploid
A ploidy quality inhering in a bearer by virtue of the bearer's containing an integral multiple of the monoploid number, possibly excluding the sex-determining chromosomes.
Wikipedia:http://en.wikipedia.org/wiki/Euploid
A monadic quality of continuant that exists at the cellular level of organisation.
quality
PATO:0001396
cellular quality
A monadic quality of continuant that exists at the cellular level of organisation.
PATOC:GVG
A cellular quality inhering in a bearer by virtue of bearer's number of nuclei.
quality
PATO:0001404
nucleate quality
A cellular quality inhering in a bearer by virtue of bearer's number of nuclei.
PATOC:GVG
A nucleate quality inhering in a bearer by virtue of the bearer's having two nuclei.
quality
PATO:0001406
binucleate
A nucleate quality inhering in a bearer by virtue of the bearer's having two nuclei.
Biology-online:Biology-online
A nucleate quality inhering in a bearer by virtue of the bearer's having one nucleus.
quality
PATO:0001407
mononucleate
A nucleate quality inhering in a bearer by virtue of the bearer's having one nucleus.
Biology-online:Biology-online
A shape quality inhering in a bearer by virtue of the bearer's terminating in a point or edge.
quality
PATO:0001419
sharp
A shape quality inhering in a bearer by virtue of the bearer's terminating in a point or edge.
PATOC:GVG
A structural quality inhering in a bearer by virtue of whether the bearer includes all its components.
quality
PATO:0001442
wholeness
A structural quality inhering in a bearer by virtue of whether the bearer includes all its components.
thefreedictionary.com:thefreedictionary.com
A broken quality inhering in a bearer by virtue of the bearer's being broken open.
PATO:0001443
PATO:0001820
burst
fractured
fragmented
ruptured
quality
cracked
hemorrhaged
split
torn
PATO:0001444
broken
A broken quality inhering in a bearer by virtue of the bearer's being broken open.
PATOC:GVG
A shape quality inhering in a bearer by virtue of the bearer's being gradually narrower or thinner toward one end.
taper
quality
PATO:0001500
tapered
A shape quality inhering in a bearer by virtue of the bearer's being gradually narrower or thinner toward one end.
WordNet:WordNet
A pattern inhering in a surface by virtue of the bearer's being marked by the presence of dots, punctures, points or pits.
quality
dotted
spotted
stippled
PATO:0001512
punctate
A pattern inhering in a surface by virtue of the bearer's being marked by the presence of dots, punctures, points or pits.
medical-dictionary:medical-dictionary
The number of parts of a particular type that the bearer entity has. This is a relational quality, and thus holds between two entities: the bearer of the quality, and the type of parts.
OBO_REL:has_part
extra or missing physical or functional parts
has or lacks parts of type
mereological quality
number of
quality
cardinality
number
PATO:0001555
has number of
The number of parts of a particular type that the bearer entity has. This is a relational quality, and thus holds between two entities: the bearer of the quality, and the type of parts.
PATOC:CJM
A quality of a process inhering in a bearer by virtue of the bearer's lacking a processual part as specified by the additional entity.
quality
PATO:0001558
lacking processual parts
A quality of a process inhering in a bearer by virtue of the bearer's lacking a processual part as specified by the additional entity.
PATOC:GVG
A mass which is lower than normal or average.
PATO:0000579
low mass
small mass
quality
PATO:0001562
decreased mass
A mass which is lower than normal or average.
PATO:GVG
A mass which is higher than normal or average.
PATO:0000578
high mass
large mass
quality
PATO:0001563
increased mass
A mass which is higher than normal or average.
PATO:GVG
A quality of a process inhering in a bearer by virtue of the bearer's processual parts.
quality
PATO:0001564
extra or missing processual parts
A quality of a process inhering in a bearer by virtue of the bearer's processual parts.
PATOC:GVG
A surface shape quality inhering in a bearer by virtue of the bearer's exhibiting a degree of bending.
quality
PATO:0001591
curvature
A surface shape quality inhering in a bearer by virtue of the bearer's exhibiting a degree of bending.
WordNet:WordNet
A morphological quality inhering in a bearer by virtue of the bearer's being distorted in form.
quality
disfigured
distorted
PATO:0001617
deformed
A morphological quality inhering in a bearer by virtue of the bearer's being distorted in form.
thefreedictionary.com:thefreedictionary.com
A spatial pattern inhering in a bearer by virtue of the bearer's being gathered or tending to gather into a mass or whole.
clustered
quality
PATO:0001629
aggregated
A spatial pattern inhering in a bearer by virtue of the bearer's being gathered or tending to gather into a mass or whole.
WordNet:WordNet
A positional quality inhering in a bearer by virtue of the bearer's being distributed or spread over a considerable extent.
quality
PATO:0001630
dispersed
A positional quality inhering in a bearer by virtue of the bearer's being distributed or spread over a considerable extent.
WordNet:WordNet
A size quality inhering in a bearer by virtue of the bearer's having a short, stocky build.
quality
PATO:0001643
stubby
A size quality inhering in a bearer by virtue of the bearer's having a short, stocky build.
thefreedictionary.com:thefreedictionary.com
A size quality inhering in an bearer by virtue of the bearer's extension in one dimension.
1-D size
quality
PATO:0001708
1-D extent
A size quality inhering in an bearer by virtue of the bearer's extension in one dimension.
PATOC:GVG
A size quality inhering in an bearer by virtue of the bearer's extension in two dimensions.
2-D size
quality
PATO:0001709
2-D extent
A size quality inhering in an bearer by virtue of the bearer's extension in two dimensions.
PATOC:GVG
A size quality inhering in an bearer by virtue of the bearer's extension in three dimensions.
3D size
quality
PATO:0001710
3-D extent
A size quality inhering in an bearer by virtue of the bearer's extension in three dimensions.
PATOC:GVG
A quality that inheres in an bearer by virtue of how that bearer interacts with radiation.
quality
PATO:0001739
radiation quality
A quality that inheres in an bearer by virtue of how that bearer interacts with radiation.
PATOC:GVG
A spatial quality inhering in a bearer by virtue of the bearer's being extended on all sides of another entity simultaneously.
encircling
quality
PATO:0001772
surrounding
A spatial quality inhering in a bearer by virtue of the bearer's being extended on all sides of another entity simultaneously.
thefreedictionary.com:thefreedictionary.com
A shape quality inhering in a bearer by virtue of the bearer's having three angles.
deltoid
quality
triangle
triangle-shaped
PATO:0001875
triangular
A shape quality inhering in a bearer by virtue of the bearer's having three angles.
wordreference:wordreference
A shape quality inhering in a bearer by virtue of the bearer's consisting of two curves, in opposite directions. S-shaped.
S-shaped
sigmoidal
quality
PATO:0001878
sigmoid
A shape quality inhering in a bearer by virtue of the bearer's consisting of two curves, in opposite directions. S-shaped.
PATOC:CJM
A shape quality inhering in a bearer by virtue of the bearer's forming two equal obtuse triangles with a short side in common.
sagittate
quality
PATO:0001881
Gradually enlarged at the base, like the head of an arrow.
arrow-shaped
A shape quality inhering in a bearer by virtue of the bearer's forming two equal obtuse triangles with a short side in common.
ISBN:0881923214
RKC:RKC
A physical quality inhering in a bearer by virtue of the bearer's participation in movement.
quality
PATO:0001906
movement quality
A physical quality inhering in a bearer by virtue of the bearer's participation in movement.
PATOC:GVG
A nucleate quality inhering in a bearer by virtue of the bearer's having more than one nucleus.
quality
PATO:0001908
multinucleate
A nucleate quality inhering in a bearer by virtue of the bearer's having more than one nucleus.
PATOC:GVG
A surface shape quality inhering in a bearer by virtue of the bearer's shape of features present on its surface or outer shell.
quality
PATO:0001925
This quality either inheres directly in the surface, or in the entity that has the surface. For example, to say that a particular fly wing is curved is shorthand for saying the wing has a surface which is curved.
surface feature shape
A surface shape quality inhering in a bearer by virtue of the bearer's shape of features present on its surface or outer shell.
PATOC:CJM
A variability quality inhering in a bearer by virtue of whether the bearer exhibits shape variation or change.
quality
PATO:0001929
variability of shape
A variability quality inhering in a bearer by virtue of whether the bearer exhibits shape variation or change.
PATOC:GVG
A variability quality inhering in a bearer by virtue of whether the bearer exhibits size variation or change.
quality
PATO:0001956
variability of size
A variability quality inhering in a bearer by virtue of whether the bearer exhibits size variation or change.
PATOC:GVG
A variability of size which is relatively high.
high variability of size
quality
PATO:0001958
increased variability of size
A variability of size which is relatively high.
PATOC:GVG
A shape quality inhering in a bearer by virtue of the bearer's being partly divided into a determinate number of regions.
quality
PATO:0001979
lobed
A shape quality inhering in a bearer by virtue of the bearer's being partly divided into a determinate number of regions.
ISBN:0881923214
A quality that inheres in an entire organism or part of an organism.
quality
PATO:0001995
organismal quality
A quality that inheres in an entire organism or part of an organism.
PATOC:CJM
The bearer of this quality has_part < n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly. This case includes the limit case, where the bearer lacks all parts of the specified type.
loss of
quality
PATO:0001999
lacks parts or has fewer parts of type
The bearer of this quality has_part < n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly. This case includes the limit case, where the bearer lacks all parts of the specified type.
PATOC:CJM
A quality of physical entities inhering in a bearer by virtue of the bearer's lacking a physical part as specified by the additional entity.
PATO:0001557
OBO_REL:lacks_part
lacks all physical parts of type
quality
PATO:0002000
Example: [E=organism Q=lacks_all_parts_of_type E2=Wing] - applies to an organism. A relational quality in which the bearer entity has no parts of the specified type. The bearer of this quality has_part = 0 of the indicated entity type, where a comparable organism usually has at least 1 part of the same type. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e lacks all parts of type X at time t, then there exists no instances x of X at t such that x part_of e that has no wings, where wings are normally present in that organism type. In OWL this is equivalent to a restriction on the OBO_REL:has_part relation with cardinality=0, i.e has_part 0 E2.
lacks all parts of type
A quality of physical entities inhering in a bearer by virtue of the bearer's lacking a physical part as specified by the additional entity.
PATOC:CJM
The bearer of this quality has_part < n AND has_part > 0 of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly.
PATO:0001569
decreased number of
has decreased number of
has fewer physical parts of type
quality
PATO:0002001
Example: [E=hand Q=has_fewer_parts_of_type E2=digit] - applies to an organism that has no less fingers than is normal for organisms of that type.
has fewer parts of type
The bearer of this quality has_part < n AND has_part > 0 of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly.
PATOC:CJM
The bearer of this quality has_part > n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part.
PATO:0001560
has extra parts of
has increased number of
having extra physical parts
having supernumerary physical parts
increased number of
quality
PATO:0002002
In polydactyly, the bearer of the quality is the hand, and the entity type being counted is 'finger'. In EQ syntax, E=hand, Q=<this> E2=finger.
has extra parts of type
The bearer of this quality has_part > n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part.
PATOC:CJM
A shape that inheres in a 2 dimensional entity, such as a cross section or projection of a 3 dimensional entity.
quality
2-D projection
cross-sectional
PATO:0002006
2-D shape
A shape that inheres in a 2 dimensional entity, such as a cross section or projection of a 3 dimensional entity.
PATOC:CJM
An occurrence which is relatively high.
George Gkoutos
2009-03-26T11:10:11Z
increased incidence
quality
PATO:0002051
increased occurrence
An occurrence which is relatively high.
PATOC:GVG
An occurrence which is relatively low.
George Gkoutos
2009-03-26T11:12:35Z
decreased incidence
quality
PATO:0002052
decreased occurrence
An occurrence which is relatively low.
PATOC:GVG
An area which is relatively high.
George Gkoutos
2009-03-30T04:11:43Z
quality
PATO:0002057
increased area
An area which is relatively high.
PATOC:GVG
An area which is relatively low.
George Gkoutos
2009-03-30T04:12:11Z
quality
PATO:0002058
decreased area
An area which is relatively low.
PATOC:GVG
george
2009-06-05T09:16:46Z
quality
PATO:0002062
physical quality of a process
A shape quality inhering in a bearer by virtue of the bearer's being arranged like rays or radii; radiating from a common center.
George Gkoutos
2009-07-01T01:48:19Z
stellate
quality
PATO:0002065
star shaped
A shape quality inhering in a bearer by virtue of the bearer's being arranged like rays or radii; radiating from a common center.
PATOC:me
Having extra or fewer parts.
George Gkoutos
2009-09-21T10:41:58Z
quality
PATO:0002083
altered number of
Having extra or fewer parts.
PATOC:GVG
A positional quality inhering in a bearer by virtue of the bearer's being at the edge or boundary of a related entity.
george
2009-10-05T02:58:16Z
quality
PATO:0002107
peripheral
A positional quality inhering in a bearer by virtue of the bearer's being at the edge or boundary of a related entity.
PATOC:GVG
A quality which inheres in a molecular entity, a single molecule, atom, ion, radical etc.
George Gkoutos
2010-03-10T03:18:15Z
PATO:0002061
relational molecular quality
quality
PATO:0002182
molecular quality
A quality which inheres in a molecular entity, a single molecule, atom, ion, radical etc.
PATOC:GVG
A lobed quality inhering in a bearer by virtue of the bearer's being divided into or having two lobes.
george
2010-07-08T01:54:08Z
quality
PATO:0002214
bilobed
A lobed quality inhering in a bearer by virtue of the bearer's being divided into or having two lobes.
thefreedictionary:http://www.thefreedictionary.com/bilobed
A quality inhering in a bearer that is shaped in the form of a fan.
george
2010-07-09T01:43:42Z
fan-like
quality
PATO:0002219
fan-shaped
A quality inhering in a bearer that is shaped in the form of a fan.
thefreedictionary:http://www.thefreedictionary.com/fan-shaped
A structural quality inhering in a bearer by virtue of the bearer's being arranged in a systematic fashion.
george
2010-09-16T10:22:52Z
quality
PATO:0002264
organization quality
A structural quality inhering in a bearer by virtue of the bearer's being arranged in a systematic fashion.
PATOC:GVG
A positional quality inhering in a bearer by virtue of the bearer's being located in a position equidistant from edges.
george
2010-10-05T01:09:32Z
quality
PATO:0002268
centered
A positional quality inhering in a bearer by virtue of the bearer's being located in a position equidistant from edges.
PATOC:OREGON
A quality that has a value that is increased compared to normal or average.
George Gkoutos
2011-06-16T06:39:43Z
quality
PATO:0002300
increased quality
A quality that has a value that is increased compared to normal or average.
PATOC:GVG
A quality that has a value that is decreased compared to normal or average.
George Gkoutos
2011-06-16T06:40:15Z
quality
PATO:0002301
decreased quality
A quality that has a value that is decreased compared to normal or average.
PATOC:GVG
A quality of a process that has a value that is decreased compared to normal or average.
George Gkoutos
2011-06-16T06:50:59Z
quality
PATO:0002302
decreased process quality
A quality of a process that has a value that is decreased compared to normal or average.
PATOC:GVG
A quality of an object that has a value that is decreased compared to normal or average.
George Gkoutos
2011-06-16T06:51:54Z
quality
PATO:0002303
decreased object quality
A quality of an object that has a value that is decreased compared to normal or average.
PATOC:GVG
A quality of a process that has a value that is increased compared to normal or average.
George Gkoutos
2011-06-16T06:53:08Z
quality
PATO:0002304
increased process quality
A quality of a process that has a value that is increased compared to normal or average.
PATOC:GVG
A quality of an object that has a value that is increased compared to normal or average.
George Gkoutos
2011-06-16T06:54:01Z
quality
PATO:0002305
increased object quality
A quality of an object that has a value that is increased compared to normal or average.
PATOC:GVG
A shape constituting a transition between a rectangle and a circle; a closed curve, of which the circle and ellipse are special cases, whose parametric equation is x = a.cos2/rt, y = b.cos2/rt
George Gkoutos
2011-10-12T12:45:16Z
Lamé curve
quality
PATO:0002318
superelliptic
A shape constituting a transition between a rectangle and a circle; a closed curve, of which the circle and ellipse are special cases, whose parametric equation is x = a.cos2/rt, y = b.cos2/rt
wiktionary:superellipse
A temporal distribution pattern of process occurrences within a regulation/reference process.
George Gkoutos
2011-11-22T01:12:28Z
quality
PATO:0002323
temporal distribution quality
A temporal distribution pattern of process occurrences within a regulation/reference process.
PATOC:LC
The temporal relation between the end of the process with respect to a reference process.
George Gkoutos
2011-11-23T11:46:00Z
quality
PATO:0002324
offset quality
The temporal relation between the end of the process with respect to a reference process.
PATOC:LC
The temporal relation between the start of the process with respect to a reference process.
George Gkoutos
2011-11-23T11:47:34Z
quality
PATO:0002325
onset quality
The temporal relation between the start of the process with respect to a reference process.
PATOC:LC
A quality inhering in a bearer by virtue of the bearer's length being notably lower than its width.
gkoutos
2012-04-18T06:31:29Z
quality
PATO:0002364
shortened
A quality inhering in a bearer by virtue of the bearer's length being notably lower than its width.
PATOC:GVG
Having a shape that resembles a many-lobed "berry," such as a raspberry.
gkoutos
2012-07-05T14:58:05Z
quality
PATO:0002378
acinus
Having a shape that resembles a many-lobed "berry," such as a raspberry.
wikipedia:https://en.wikipedia.org/wiki/Acinus
A quality that that inheres in a population of cells
CMPO:0000002
cell population phenotype
cell population phenotype
A quality that inheres in or specifically depends on a cellular process, a cell population, a whole cell or a subcellular structure.
CMPO:0000003
cellular phenotype
cellular phenotype
A collection of qualities that inhere in the whole cell relating to the cell's shape, size or structure
CMPO:0000005
cell morphology phenotype
cell morphology
A quality that inheres in a cellular process
cell physiology phenotype
CMPO:0000007
cell process phenotype
cell process phenotype
An increase or decrease in the number of specified components within a cell
CMPO:0000008
cell component number phenotype
cell component number
A collection of size qualities that inhere in a cellular component
CMPO:0000010
cell component size phenotype
cell component size
A collection of shape qualities that inhere in a cellular component
CMPO:0000011
cell component shape phenotype
cell component shape
A collection of structure qualities that inhere in a cellular component
CMPO:0000012
cell component structure phenotype
cell component structure
A phenotype relating to the ability of a cell survive or to develop normally
CMPO:0000013
cell viability phenotype
cell viability
A cell phenotype where the cell is viable
CMPO:0000014
viable cell phenotype
viable cell
A cell phenotype where the cell is not viable
CMPO:0000015
inviable cell phenotype
inviable cell
A nucleation quality that inheres in the whole cell
CMPO:0000016
cell nucleation phenotype
cell nucleation
CMPO:0000017
mononuclear cell phenotype
mononuclear cell
A multinucleate quality that inheres in a cell
polynuclear cell
CMPO:0000018
multinucleated cell phenotype
multinucleated cell
A collection of qualities that inhere in any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.
CMPO:0000020
cytoskeletal phenotype
cytoskeletal phenotype
A collection of qualities that inhere in any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
CMPO:0000021
endoplasmic reticulum phenotype
endoplasmic reticulum phenotype
A collection of qualities that inhere in any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack
CMPO:0000022
golgi phenotype
golgi phenotype
A collection of qualities that inhere in any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells.
mitochondrial part phenotype
CMPO:0000023
mitochondrion phenotype
mitochondrion phenotype
A collection of qualities that inhere in any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.
CMPO:0000024
nuclear phenotype
nuclear phenotype
A collection of qualities that inhere in a cellular organelle relating to the organelle's shape
CMPO:0000026
organelle shape phenotype
organelle shape
A collection of qualities that inhere in the nucleus relating to the ratios of distances between its features (points, edges, surfaces and also holes etc).
nuclear shape
CMPO:0000027
nucleus shape phenotype
A phenotype where the attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules is observed
CMPO:0000028
cell adhesion phenotype
cell adhesion phenotype
A collection of qualities that inhere the cell cycle
CMPO:0000029
cell cycle phenotype
cell cycle phenotype
A phenotype where the cell death process process is observed
PMID:20360735
CMPO:0000030
cell death phenotype
cell death phenotype
A phenotype observation of a process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
CMPO:0000032
cell membrane organisation phenotype
cell membrane organisation phenotype
A phenotype of a cell involving its translation from one location to another
PMID:20360735
CMPO:0000033
cell migration phenotype
cell migration phenotype
A phenotype observation of the process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
CMPO:0000035
cell growth phenotype
cell growth phenotype
A phenotype observation of the process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the alignment of chromosomes at the metaphase plate, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
CMPO:0000036
chromosome segregation phenotype
chromosome segregation phenotype
A phenotype observation of chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
CMPO:0000037
metabolic process phenotype
metabolic process phenotype
A phenotype observations where any process in which an organelle is transported to, and/or maintained in, a specific location.
CMPO:0000038
organelle localization phenotype
organelle localization phenotype
A phenotype observation where a process modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
CMPO:0000039
regulation of metabolic process phenotype
regulation of metabolic process phenotype
A phenotype observation of a process that modulates the frequency, rate or extent of signal transduction.
CMPO:0000040
regulation of signal transduction phenotype
regulation of signal transduction phenotype
A phenotype observation of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.
CMPO:0000041
transport phenotype
transport phenotype
An increased number of specified cellular components relative to normal
CMPO:0000042
increased cell component number phenotype
increased cell component number
A decrease in number of specified cellular components relative to normal
CMPO:0000043
decreased cell component number phenotype
decreased cell component number
A phenotype observation where the cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
apoptotic DNA
CMPO:0000047
apoptotic DNA fragmentation phenotype
apoptotic DNA fragmentation
A phenotype observation at the level of the cell shape where the cell is apoptotic
CMPO:0000048
dispersed outline with blobby protrusions
apoptotic cell shape phenotype
apoptotic cell shape
Groups of cells gathered or tending to gather into a mass or whole.
aggregated cells
cell aggregates
cell islands
clustered cells
CMPO:0000049
aggregated cells in population
aggregated cells in population
Number of cells in a population phenotype
CMPO:0000050
altered cell number in population
cell number in population
The population has an increased number of cells with respect to normal
CMPO:0000051
increased cell numbers
increased cell numbers
The population has a decreased number of cells with respect to normal
decreased cells
fewer cells
less cells
reduced cell numbers
CMPO:0000052
decreased cell numbers
decreased cell numbers
increased number of cells in S phase mitosis
CMPO:0000053
more cells in S
A population of cells where a specifcied biological process is occuring or is observed.
CMPO:0000054
cell population phenotype by process
cell population process
increased cell numbers in G1
CMPO:0000055
more cells in G1
increased number of cells in G2M
increased mitotic index
CMPO:0000056
more cells in G2M
decreased number of cells in G1 phase
less cells in G1
CMPO:0000057
fewer cells in G1
decreased number of cells in G2M phase
decreased mitotic index
less cells in G2M
CMPO:0000058
fewer cells in G2M
decreased number of cells in S phase
decreased number of cells in S
less cells in S
CMPO:0000059
fewer cells in S
A phenotype observation at the level of focal adhesions where the components number has decreased.
decreased focal adhesion abundance
CMPO:0000063
decreased number of focal adhesion phenotype
decreased number of focal adhesion
A phenotype observation where the focal adhesion is located in a position equidistant from the edges of the cell
PMID:19667130
CMPO:0000064
centrally located focal adhesion phenotype
centrally located focal adhesion
A phenotype observation at the level of a cellular component relating to the components position in the cell
CMPO:0000065
cell component position phenotype
cell component position
A phenotype observation where the focal adhesions's position is at the edge or boundary of a related entity.
PMID:19667130
CMPO:0000066
peripheral focal adhesion phenotype
peripheral focal adhesion
A phenotype observation at the level of filopodia where the components number has decreased.
fewer filopodia
CMPO:0000067
decreased number of filopodia phenotype
decreased number of filopodia
A phenotype observation at the level of microtubules where the components number has decreased.
fewer microtubules
CMPO:0000068
decreased number of microtubules phenotype
decreased number of microtubules
A phenotype observation at the level of dendritic branches where the components number has decreased.
CMPO:0000069
decreased number of dendritic branches phenotyope
Single cell with protrusions
PMID:20531400
cell with protrusions
CMPO:0000071
cell with projections
An increase in number of any cell projection relative to normal
CMPO:0000072
increased number of cell projections phenotype
increased number of cell projections
increased number of cells in population with projections
CMPO:0000073
more cells with projections
A phenotype observation at the level of cell projections where the components number has decreased.
CMPO:0000074
decreased number of cell projections phenotype
decreased number of cell projections
decreased number of cells in population with projections
CMPO:0000075
fewer cells with projections
A phenotype observation at the level of filopodia where the components number has increased.
more filopodia
CMPO:0000076
increased number of filopodia
A phenotype observation at the level of the cell shape where the cell is elongated, with a length notably greater than its width
bipolar cell
CMPO:0000077
elongated cell phenotype
elongated cell
Cells in population with a length notably greater than their width
PMID:21893601; PMID:20531400
CMPO:0000078
elongated cells in population
elongated cells in population
A phenotype observation at the level of lamellipodia where the components number has increased.
lamellipodium phenotype
CMPO:0000080
increased number of lamellipodia phenotype
increased number of lamellipodia
A phenotype observation at the level of lamellipodia where the components number has decreased.
CMPO:0000081
decreased number of lamellipodia phenotype
decreased number of lamellipodia
increased lamellipodia cells in population phenotype
CMPO:0000083
more lamellipodia cells
decreased lamellipodia cells in population phenotype
CMPO:0000084
fewer lamellipodia cells
A phenotype observation at the level of the whole cell relating to the cell's ploidy
CMPO:0000085
cell ploidy phenotype
cell ploidy
A cell phenotype with more than two homologous sets of chromosomes.
CMPO:0000086
polyploid cell phenotype
polyploid cell
A phenotype observation at the level of athe S phase of the mitotic cell cycle
CMPO:0000087
S phase mitotic phenotype
S phase mitotic phenotype
A phenotype observation at the level of a G1 phase of the mitotic cell cycle
CMPO:0000088
G1 phase mitotic phenotype
G1 phase mitotic phenotype
A phenotype observation at the level of the G2/M transition of the mitotic cell cycle
CMPO:0000089
G2/M transition phenotype
G2/M transition phenotype
A phenotype observation at the level of a cell cycle phase
CMPO:0000090
cell cycle phase phenotype
cell cycle phase phenotype
increased number of polyploid cells in population
CMPO:0000091
more polyploid cells
A phenotype observation at the level of focal adhesions where the components number has increased.
increased focal adhesion abundance
CMPO:0000092
increased number of focal adhesion phenotype
increased number of focal adhesion
A phenotype observation at the level of nucleoli where the components number has increased.
CMPO:0000093
increased number of nucleoli phenotype
increased number of nucleoli
A phenotype observation at the level of nucleoli where the components number has decreased.
CMPO:0000094
decreased number of nucleoli phenotype
decreased number of nucleoli
more cells with decreased number of nucleoli
CMPO:0000095
more cells with decreased number of nucleoli
increased number of nucleoli in population phenotype
CMPO:0000096
more cells with increased number of nucleoli
A phenotype observation at the level of microtubules where the components number has increased.
more microtubules
CMPO:0000097
increased number of microtubules phenotype
increased number of microtubules
A phenotype observation at the level of the phagosomes, a membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
phagosomes present phenotype
CMPO:0000102
phagosomes phenotype
phagosomes
A phenotype observation where phagosomes are absent
CMPO:0000103
phagosomes absent phenotype
phagosomes absent
A phenotype observation at the level of the actin filaments, a filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells.
CMPO:0000104
actin filament phenotype
actin filament phenotype
A phenotype observation at the level of actin filaments where the components number has increased.
PMID: 21893601
PMID:20531400
actin fiber cells
more actin
more total actin
CMPO:0000105
increased number of actin filament phenotype
increased number of actin filament
A phenotype observation at the level of actin filaments where the components number has decreased.
PMID: 21893601
less actin
less total actin
CMPO:0000106
decreased number of actin filament phenotype
decreased number of actin filament
increased number of actin filament cells in population
CMPO:0000107
more actin filament cells
decreased number of actin filament phenotypes in population
decreased number of actin filament cells
CMPO:0000108
fewer actin filament cells
A phenotype observation where the cytoskeleton is located in a position equidistant from the edges of the cell
CMPO:0000109
centered cytoskeleton phenotype
centered cytoskeleton
A phenotype observation where the nucleus is located in a position equidistant from the edges of the cell
CMPO:0000110
centered nucleus phenotype
centered nucleus
A phenotype observation where the nucleus is distributed or spread over a considerable extent.
CMPO:0000111
dispersed nucleus phenotype
dispersed nucleus
A phenotype observation at the level of nucleus consisting of blebbing of the nucleus and DNA fragmentation due to the cell undergoing a specific form of programmed cell death termed apoptosis.
CMPO:0000112
apoptopic nucleus phenotype
apoptopic nucleus
A phenotype observation where the nucleus is distorted in form
CMPO:0000113
deformed nucleus
A phenotype observation where the nucleus's position is at the edge or boundary of a related entity.
CMPO:0000114
peripheral nucleus phenotype
peripheral nucleus
A phenotype observation where the cytoskeleton's position is at the edge or boundary of a related entity.
CMPO:0000115
peripheral cytoskeleton phenotype
peripheral cytoskeleton
A phenotype observation at the level of the cell shape where the shape is abnormal
CMPO:0000116
abnormal cell shape phenotype
abnormal cell shape
A lobed quality inhering in a nucleus by virtue of the nucleus being divided into or having two lobes.
bilobed
CMPO:0000117
bilobed nucleus phenotype
bilobed nucleus
A phenotype observation at the level of the cell shape where the cell is round
PMID:21893601
circular cell
low eccentricity cell
spherical cell
CMPO:0000118
not spreading cell
round cell phenotype
round cell
A phenotype observation of the length of the focal adhesion is notably higher than the width.
long focal adhesion
CMPO:0000119
elongated focal adhesion
A phenotype observation of the length of the nucleus is notably higher than the width.
long nucleus
CMPO:0000120
elongated nucleus
A phenotype observation at the level of the cell shape where the cell is arrow shaped, with a wide front and a sharp tail, displaying monopolar cell growth
triangular shaped cell
CMPO:0000121
arrow shaped cell phenotype
A phenotype observation at the level of the cell shape where the cell has a triangular shape, with a wide front and a sharp tail, displaying cell motility
arrow shaped cell
CMPO:0000122
triangular shaped cell phenotype
triangular shaped cell
A phenotype observation where the shape of the nucleus has every part of the surface or the circumference equidistant from the center.
circular nucleus
round nucleus
CMPO:0000123
round nucleus phenotype
round nucleus
A phenotype observation at the level of the nuclear body, an extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
CMPO:0000125
nuclear body phenotype
nuclear body
A phenotype observation where the nuclear body size is relatively high.
PMID:22884692
CMPO:0000126
increased nuclear body size phenotype
increased nuclear body size
A phenotype observation where the nuclear body size is relatively low.
PMID:22884692
CMPO:0000127
decreased nuclear body size phenotype
decreased nuclear body size
A phenotype observation at the level of the cell size where a cell is larger with respect to normal/wild-type
PMID:20531400
big cell
increased cell area
large cell
CMPO:0000128
increased cell size phenotype
increased cell size
A phenotype observation at the level of the cell size where a cell is smaller with respect to normal/wild-type
small cell
CMPO:0000129
decreased cell size phenotype
A phenotype observation at the level of the golgi where the golgi's volume has decreased.
CMPO:0000130
decreased golgi volume phenotype
decreased golgi volume
A phenotype observation at the level of the golgi where the golgi's volume has increased.
CMPO:0000131
increased golgi volume phenotype
increased golgi volume
A phenotype observation at the level of a cilium where the components length has decreased.
CMPO:0000132
decreased cilium length phenotype
decreased cilium length
A phenotype observation at the level of a cilium where the components length has increased.
CMPO:0000133
increased cilium length phenotype
increased cilium length
A phenotype observation where the size of the focal adhesion has decreased.
CMPO:0000134
decreased size of focal adhesion phenotype
decreased size of focal adhesion
A phenotype observation where the size of the focal adhesion has increased.
CMPO:0000135
increased size of focal adhesion phenotype
increased size of focal adhesion
A phenotype observation where the area of the focal adhesion has decreased.
pmid:19667130
small focal adhesion
CMPO:0000136
decreased focal adhesion area phenotype
decreased focal adhesion area
A phenotype observation where the area of the focal adhesion has increased.
pmid:19667130
large focal adhesion
CMPO:0000137
increased focal adhesion area phenotype
increased focal adhesion area
A phenotype observation where the length of the focal adhesion has decreased.
pmid:19667130
short focal adhesion
CMPO:0000138
decreased focal adhesion length phenotype
decreased focal adhesion length
A phenotype observation where the length of the focal adhesion has increased.
CMPO:0000139
increased focal adhesion length phenotype
increased focal adhesion length
A phenotype observation where the size of the nucleus has increased
PMID:20360735
PMID:20531400
increased DNA area
large nuclei
large nucleus
CMPO:0000140
increased nucleus size phenotype
increased nucleus size
A phenotype observation where the size of the nucleus has decreased
PMID:20360735
PMID:21893601
decreased DNA area
small nucleus
CMPO:0000141
decreased nucleus size phenotype
decreased nucleus size
A phenotype of a cell that has both an increased nuclei size phenotypes and a G1 phase phenotype
CMPO:0000143
increased nuclei size in G1 phenotype
increased nuclei size in G1
A phenotype of a cell that has both a decreased nuclei size phenotypes and a G1 phase phenotype
small nuclei in G1
CMPO:0000144
decreased nuclei size in G1 phenotype
decreased nuclei size in G1
A phenotype observation where the thickness of the dendritic branches has increased.
CMPO:0000145
increased thickness of dendritic branches phenotype
increased thickness of dendritic branches
A phenotype observation where the thickness of the dendritic branches has decreased.
CMPO:0000146
decreased thickness of dendritic branches
A phenotype observation where the microtublue structure is disorganised
pmid:21893601
microtubule disorganised
CMPO:0000147
disorganized microtubules phenotype
disorganized microtubules
A phenotype observation at the level of podosomes, an actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell.
CMPO:0000148
podosome phenotype
podosome
A phenotype observation where the cytoskeleton is symmetric, having equal proportions around a central point or axis.
CMPO:0000149
radial cytoskeleton phenotype
radial cytoskeleton
Phenotype observation organised by specific named organelles.
CMPO:0000150
organelle phenotype
A phenotype observation where the structure of the endoplasmic reticulum is fragmented or broken.
broken endoplasmic reticulum
CMPO:0000151
fragmented endoplasmic reticulum phenotype
fragmented endoplasmic reticulum
A phenotype observation at the level of the golgi where the golgi's structure is broken
broken golgi
broken golgi phenotype
CMPO:0000152
fragmented golgi phenotype
fragmented golgi
A phenotype observation where the structure of the mitochondria is fragmented or broken.
broken mitochondria
CMPO:0000153
fragmented mitochondria phenotype
fragmented mitochondria
A phenotype observation where the nuclear's color brightness is relatively high.
PMID:20531400
CMPO:0000154
bright nuclei phenotype
bright nuclei
A phenotype observation where the structure of the nucleus is fragmented or broken.
broken nucleus
CMPO:0000155
fragmented nucleus phenotype
fragmented nucleus
A phenotype observation where nuclear envelopes form around single chromosomes or small sets of chromosomes. Forming a grape like structure
pmid:20360735
grape
CMPO:0000156
Mitocheck
Publication: http://www.ncbi.nlm.nih.gov/pubmed/20360735
Micronucleation, i.e. presumably nuclear envelopes around single chromosomes or small sets of chromosomes.
graped micronucleus phenotype
graped micronucleus
A phenotype observation where the shape of the nucleus is abnormal
PMID:20360735
abnormal nuclear shape
strange nuclear shape
CMPO:0000157
abnormal nucleus shape phenotype
A phenotype observation at the level of the G2/M transition of the mitotic cell cycle where the nuclei are decreased in size with respect to normal
CMPO:0000158
decreased nuclei size in G2/M phenotype
decreased nuclei size in G2/M
A phenotype observation at the level of a cellular component where the cell component is absent
CMPO:0000159
absence of cellular component phenotype
absence of cellular component
A phenotype of a cell population relating to the ability of the cells to live and develop normally
CMPO:0000160
cell population viability phenotype
cell viability in population phenotype
increased number of viable cell phenotype in a population
CMPO:0000161
increased cell viability in population
increased cell viability in population
decreased number of viable cell phenotype in a population
CMPO:0000162
decreased cell viability in population
decreased cell viability in population
A population phenotype relating to the size, shape or structure of the cells within a population
CMPO:0000163
cell population phenotype by morphology
cell population morphology
A phenotype that results in the absence of cytokinesis
CMPO:0000164
absence of cytokinesis phenotype
absence of cytokinesis
A phenotype observation at the level of cytokinesis
CMPO:0000165
cytokinesis phenotype
cytokinesis phenotype
A phenotype observation of the process resulting in the physical partitioning and separation of a cell into daughter cells.
CMPO:0000166
cell division phenotype
cell division phenotype
A phenotype where the cell division process occurs at a higher rate
faster cell division
CMPO:0000168
increased rate of cell division phenotype
increased rate of cell division
A phenotype where the cell division process occurs at a lower rate
slower cell division
CMPO:0000169
decreased rate of cell division phenotype
decreased rate of cell division
A phenotype observation of the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence.
CMPO:0000170
telomerase activity phenotype
telomerase activity phenotype
A phenotype observation where the occurane of telomerase activity is decreased
CMPO:0000171
decreased telomerase activity phenotype
decreased telomerase activity
A phenotype observation where the occurane of telomerase activity is increased
CMPO:0000172
increased telomerase activity phenotype
increased telomerase activity
A phenotype of a cell that is arrested at the G0/1 transition
CMPO:0000173
(from GO) Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells.
G0/1 arrested phenotype
G0/1 arrested
A phenotype observation where the endoplasmic reticulum is oriented in the cell with extremities at either end of the main axis.
polarized endoplasmic reticulum
CMPO:0000174
polarized endoplasmic reticulum phenotype
polarized endoplasmic reticulum
A quality that inheres in a molecular component of a cell
CMPO:0000175
molecular component phenotype
molecular component phenotype
A phenotype observation at the level of the cell DNA
CMPO:0000176
cell DNA phenotype
cell DNA phenotype
A shape quality that inheres in a DNA molecule where the shape of the molecule is abnormal.
CMPO:0000177
This phenotype often results in a nucleus with an irregular shape phenotype.
misshapen DNA
A phenotype observation at the level of the site of double-strand break, a region of a chromosome at which a DNA double-strand break has occurred.
CMPO:0000180
site of double-strand break phenotype
site of double-strand break
A phenotype observation at the level of double strand breaks where the components number has decreased.
CMPO:0000181
decreased number of site of double-strand break phenotype
decreased number of site of double-strand break
A phenotype observation where the number of double-strand breaks has increased
CMPO:0000182
increased number of site of double-strand break phenotype
increased number of site of double-strand break
CMPO:0000185
cell-matrix adhesion phenotype
cell-matrix adhesion phenotype
A phenotype observation at the level of a cellular component where the components size has increased.
CMPO:0000186
increased cell component size phenotype
increased cell component size
A phenotype observation at the level of a cellular component where the components size has decreased.
CMPO:0000187
decreased cell component size phenotype
decreased cell component size
A phenotype observation where the morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
substrate adhesion-dependent cell spreading phenotype
CMPO:0000188
cell spreading phenotype
cell spreading phenotype
A phenotype observation of a biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
CMPO:0000189
cellular development phenotype
cellular development phenotype
A phenotype observation at the level of axons where the components number has decreased.
CMPO:0000190
decreased number of axons phenotype
decreased number of axons
A phenotype observation at the level of axons where the components number has increased.
CMPO:0000191
increased number of axons phenotype
increased number of axons
A phenotype observation at the level of the mitotic cell cycle
CMPO:0000194
mitotic process phenotype
mitotic process phenotype
A phenotype of a cell where a particular process is arrested, or ends earlier in time than expected
CMPO:0000195
arrested process phenotype
arrested process
A phenotype of a cell where the M phase of mitotic cell cycle process is arrested, or ends earlier in time than expected
m phase arrest
mitosis incomplete process phenotype
mitotic arrest
CMPO:0000196
M phase arrested phenotype
M phase arrested
A phenotype observation where mitosis is delayed
PMID:20360735
Mitotic delay
CMPO:0000202
mitosis delayed phenotype
mitosis delayed
A phenotype of a cell is arrested in G2 pahse of the cell cycle.
CMPO:0000203
G2 arrested phenotype
G2 arrested
A phenotype of a cell where the S phase process is arrested, or ends earlier in time than expected
CMPO:0000204
S phase arrested phenotype
S phase arrested
A phenotype observation where the duration of the exit from mitosis is increased
PMID:20711181
prolonged mitotic exit
CMPO:0000205
increased duration of exit from mitosis phenotype
increased duration of exit from mitosis
CMPO:0000206
decreased duration of exit from mitosis phenotype
decreased duration of exit from mitosis
A phenotype observation at the level of a G2 phase of the mitotic cell cycle
CMPO:0000207
G2 phase mitotic phenotype
G2 phase mitotic phenotype
A phenotype observation at the level of the mitotic metaphase of the cell cycle
CMPO:0000208
mitotic metaphase phenotype
mitotic metaphase phenotype
increased number of mitotic metaphase cells in population phenotype
CMPO:0000210
more mitotic metaphase cells
decreased number of mitotic metaphase cells in population phenotype
CMPO:0000211
fewer mitotic metaphase cells
A phenotype where the cell cycle is in some way abnormal
altered level of protein in cell nucleus
CMPO:0000212
abnormal cell cycle phenotype
abnormal cell cycle
A phenotype observation where a cell is binucleate, e.g. have two nuclei per cell
nuclei stay close together
CMPO:0000213
binuclear cell phenotype
binuclear cell
A phenotype observation where the duration of the mitotic chromosome condensation is increased
longer mitotic chromosome condensation
CMPO:0000214
increased duration of mitotic chromosome condensation phenotype
increased duration of mitotic chromosome condensation
A phenotype observation where the duration of the mitotic chromosome condensation is decreased
CMPO:0000215
decreased duration of mitotic chromosome condensation phenotype
decreased duration of mitotic chromosome condensation
A phenotype resulting from the absence of mitotic chromosome decondensation
failure in decondensation
CMPO:0000216
absence of mitotic chromosome decondensation phenotype
absence of mitotic chromosome decondensation
A phenotype resulting in the absence of mitotic process
CMPO:0000217
absence of mitotic process phenotype
absence of mitotic process
A phenotype observation at the level of mitotic chromosome condensation
CMPO:0000218
mitotic chromosome condensation phenotype
mitotic chromosome condensation phenotype
A phenotype observation at the level of mitotic chromosome decondensation
CMPO:0000219
mitotic chromosome decondensation phenotype
mitotic chromosome decondensation
A phenotype where the apoptosis process is observed
CMPO:0000220
cell apoptosis phenotype
cell apoptosis phenotype
increased number of apoptosis phenotypes in population
CMPO:0000221
more apoptosis in population
decreased number of apoptosis phenotypes in population
CMPO:0000222
less apoptosis in population
A phenotype observation where the thickness of the axon has increased.
CMPO:0000223
increased axon thickness phenotype
increased axon thickness
A phenotype observation where the thickness of the axon has decreased.
CMPO:0000224
decreased axon thickness phenotype
decresed axon thickness
A phenotype observation at the level of a axon where the components length has increased.
CMPO:0000227
increased axon length phenotype
increased axon length
A phenotype observation at the level of a axon where the components length has decreased.
CMPO:0000228
decreased axon length phenotype
decreased axon length
cell fusion event
CMPO:0000229
plasma membrane fusion occurance phenotype
plasma membrane fusion occurance
A phenotype where the cell migration process occurs at an increased rate, typically observed as a faster moving cell
PMID:20360735
CMPO:0000232
increased rate of cell migration process phenotype
increased rate of cell migration process
A phenotype where the cell migration process occurs at an redcued rate, typically observed as a slower moving cell
decreased speed of cell migration
CMPO:0000233
decreased rate of cell migration process phenotype
decreased rate of cell migration process
A phenotype observation at the level of the whole cell relating to the cell's movement
CMPO:0000234
cell movement phenotype
cell movement
A phenotype observation at the level of the cell movement where cell movement is increased
CMPO:0000235
increased cell movement phenotype
increased cell movement
A phenotype observation at the level of the cell movement where the cell moves faster than normal/wild type.
cell moves faster
increased cell migration speed
CMPO:0000236
increased cell movement speed
A phenotype observation at the level of the cell movement where the distance travelled by the cell is increased. The distance is measured as the euclidean distance between start and end point of the cell trajectory.
cells cover a longer distance
increased cell migration distance
CMPO:0000237
increased cell movement distance
A phenotype observation at the level of the cell movement where cell movement is decreased
CMPO:0000238
decreased cell movement phenotype
decreased cell movement
A phenotype observation at the level of the cell movement where the distance travelled by the cell is decreased. The distance is measured as the euclidean distance between start and end point of the cell trajectory.
cells cover a shorter distance
CMPO:0000239
decreased cell movement distance
A phenotype observation at the level of the cell movement where the cell moves slower than normal/wild type.
cell moves slower
CMPO:0000240
decreased cell movement speed
increased number of cells in population phenotype
high cell number in population
increased proliferation
CMPO:0000241
proliferating cells
A phenotype of a cell contraction caused by an actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body.
cell contraction
CMPO:0000243
actin-mediated cell contraction phenotype
actin-mediated cell contraction
A phenotype where the directed, self-propelled movement of a cellular component without the involvement of an external agent such as a transporter or a pore is observed
CMPO:0000244
cell component movement phenotype
cell component movement
A phenotype observation of the controlled release of a substance by a cell.
CMPO:0000245
cell secretion phenotype
cell secretion phenotype
A phenotype observation where the rate of release of proteins from a cell is increased
PMID:22660414
enhanced protein secretion
CMPO:0000246
increased rate of protein secretion
A phenotype observation where the rate of release of proteins from a cell is decreased
inhibition of protein secretion
CMPO:0000247
decreased rate of protein secretion
A phenotype observation at the level of the nucleus relating to the nuclear morphology
CMPO:0000249
nuclear morphology phenotype
nuclear morphology
A phenotype observation at the level of the golgi relating to the golgi's morphology
CMPO:0000250
golgi morphology phenotype
golgi morphology
A phenotype observation at the level of the cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface.
CMPO:0000251
cilium phenotype
cilium phenotype
A phenotype observation at the level of a cilium relating to the components shape, size or structure
CMPO:0000252
cilium morphology phenotype
cilium morphology
A quality that inherers in a single or whole cell.
CMPO:0000258
single cell phenotype
single cell phenotype
A quality that inheres in the cellular component of a cell
CMPO:0000259
cellular component phenotype
cellular component phenotype
A phenotype observation at the level of the cell shape where the cell has a geometric shape with straight edges
PMID:21893601
CMPO:0000261
request geometric shape in pato
geometric cell phenotype
geometric cell
Fragmented and condensed DNA during or following apoptosis
CMPO:0000262
apoptotic DNA
apoptotic DNA
Increased occurrence of mitotic cells
increased number of mitotic cells
increased occurrence of mitosis
CMPO:0000263
more cells in M phase
decreased occurrence of mitotic cells in population
decreased number of cell in mitosis
decreased number of mitotic cells
decreased occurrence of mitosis
less cells in M phase
CMPO:0000264
fewer cells in M phase
A phenotype observation at the level of the M phase of the mitotic cell cycle
CMPO:0000265
M phase mitotic phenotype
M phase mitotic phenotype
A phenotype observation where more lamellipoda is localised to one side of the cell with respect to the other
PMID:21893601
asymmetric lamellae
CMPO:0000266
asymmetric lamellipodia phenotype
asymmetric lamellipodia
A phenotype observation at the level of the cell shape where the cell has a star-like or bristly shape
PMID:21893601
spiky cell
CMPO:0000267
star shaped cell phenotype
star shaped cell
A phenotype observation at the level of the cell shape where the cell has a star-like or bristly shape
PMID:21893601
CMPO:0000268
spiny shaped cell phenotype
spiny shaped cell
A population of cells where the cells exhibit a high variability of size
variable cell size
CMPO:0000269
increased variability of cell size in population
A population of cells where the cells exhibit a high variability of shape
variable cell shape
CMPO:0000270
increased variability of cell shape in population
A phenotype observation at the level of the cortical actin cytoskeleton, the portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
peripheral actin phenotype
CMPO:0000271
cortical actin cytoskeleton phenotype
cortical actin cytoskeleton phenotype
A phenotype observation at the level of the cortical actin cytoskeleton where the components mass has increased.
PMID:21893601
increased peripheral actin
CMPO:0000272
increased cortical actin cytoskeleton mass phenotype
increased cortical actin cytoskeleton mass
A phenotype observation at the level of the cortical actin cytoskeleton where the components mass has decreased.
PMID:21893601
decreased peripheral actin
CMPO:0000273
decreased cortical actin cytoskeleton mass phenotype
decreased cortical actin cytoskeleton mass
A phenotype observation at the level of the cortical actin cytoskeleton where the component shows an irregular organization
PMID:21893601
disorganised peripheral actin phenotype
CMPO:0000274
disorganised cortical actin cytoskeleton phenotype
disorganised cortical actin cytoskeleton
A phenotype observation at the level of a lamellipodia where the components width has increased.
PMID:21893601
increased width of lamellae
CMPO:0000276
increased lamellipodia width phenotype
increased lamellipodia width
A phenotype observation at the level of a lamellipodia where the components width has decreased.
PMID:21893601
decreased width of lamellae
CMPO:0000277
decreased lamellipodia width phenotype
decreased lamellipodia width
A phenotype observation where the lamellipodia is shaped in the form of a fan.
PMID:21893601
motile lamellae
CMPO:0000278
fan-shaped lamellipodia phenotype
fan-shaped lamellipodia
A phenotype observation at the level of a cell with an increased amount of lamellipodia.
CMPO:0000279
lamellipodium phenotype
lamellipodium phenotype
A phenotype observation at the level of a cellular component relating to a prolongation or process extending from a cell, e.g. a cilium, lamellipodium or axon.
CMPO:0000280
cell projection phenotype
cell projection phenotype
A phenotype observation at the level of the filopodium; a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast.
CMPO:0000281
filopodium phenotype
filopodium
Cells not stopping at confluence and growing on top of each other in layers
PMID:21893601
layered cells
CMPO:0000282
layered cells in population
A phenotype observation at the level of the actin cytoskeleton, the part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
CMPO:0000283
actin cytoskeleton phenotype
actin cytoskeleton
A phenotype observation at the level of a actin cytoskeleton where the components mass has increased
PMID:21893601
CMPO:0000284
increased actin cytoskeleton mass phenotype
increased actin cytoskeleton mass
A phenotype observation at the level of a actin cytoskeleton where the components mass has decreased.
PMID:21893601
CMPO:0000285
decreased actin cytoskeleton mass phenotype
decreased actin cytoskeleton mass
A phenotype observation where microtubules form clump-like structures as opposed to filaments
PMID:21893601
microtubule clumps
CMPO:0000286
aggregated microtubules phenotype
aggregated microtubules
A phenotype observation where the microtubules form two crescent shaped brackets around the nucleus
PMID:21893601
CMPO:0000287
microtubules nuclear bracket phenotype
microtubules nuclear bracket
A phenotype observation where the microtubules form a ring around the nucleus
PMID:21893601
microtubule nuclear ring
CMPO:0000288
microtubules nuclear ring phenotype
microtubules nuclear ring
A phenotype observation at the level of any stress fibers where the components number has increased.
pmid:21893601
more actin stress fibers
CMPO:0000289
increased amount of stress fibers phenotype
increased amount of stress fibers
A phenotype observation where actin is observed as small patches or spots all over the cell
puncta actin filament phenotype
CMPO:0000290
punctate actin foci phenotype
punctate actin foci
A phenotype observation where a cell has an increased amount of actin observed as small patches or spots all over the cell
PMID:21893601
increased actin puncta
more actin puncta
CMPO:0000291
increased amount of punctate actin foci phenotype
increased amount of punctate actin foci
A phenotype of a culture in which cells grow as a monolayer that is attached to the culture substrate.
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20216
CMPO:0000292
cell population layer phenotype
cell layer phenotype
Loss of sheet like monolayer leading to empty patches
lost cell monolayer
CMPO:0000293
loss of cell monolayer
loss of cell monolayer
A phenotype observation where many actin filaments are observed in or around the nucleus
PMID: 21893601
increased nuclear actin
CMPO:0000294
increased actin localised to the nucleus
A phenotype observation where many actin filaments are observed in the cytoplasm
PMID: 21893601
increased cytoplasmic actin
CMPO:0000296
increased actin localised to the cytoplasm
A phenotype observation at the level of stress fibers localized to the cell cortex where the components number has increased.
pmid:21893601
more cortical actin stress fibers
CMPO:0000297
Increased amount of actin stress fibers in the cortical area
increased amount of stress fibers located in the cell cortex phenotype
increased amount of stress fibers located in the cell cortex
A phenotype observation at the level of stress fibers where the components number has increased and formed transverse arcs which are located in the cell cortex
pmid:21893601
more transverse actin stress fibers
CMPO:0000298
Increased amount of actin stress fibers, forming transverse arcs located in the cell cortex
increased amount of transverse stress fibers
A phenotype observation at the level of stress fibers where the components number has increased and formed a zig zag pattern across the cell
pmid:21893601
more zig-zag actin stress fibers
CMPO:0000299
Increased amount of actin stress fibers, with zig-zag pattern across the cell
increased amount of zig-zag stress fibers
Increased cells that are multinucleated
CMPO:0000300
more multinucleate cells
Absence of cells
PMID:21893601
CMPO:0000301
no cells phenotype
no cells
A phenotype observation where the microtubules form a ring around the nucleus
PMID:21893601
nuclear actin ring
CMPO:0000302
actin nuclear ring phenotype
actin nuclear ring
A phenotype observation at the level of a cellular component relating to the components shape, size or structure
CMPO:0000303
cell component morphology phenotype
cell component morphology
A phenotype of a cell where a particular process is arrested, or ends earlier in time than expected
CMPO:0000304
cell cycle arrested phenotype
cell cycle arrested
A phenotype of a cell arrested in mitotic metaphase
PMID:20360735
metaphase arrest
CMPO:0000305
metaphase arrested phenotype
metaphase arrested
A phenotype of a cell where a particular process is delayed
CMPO:0000306
delayed process phenotype
delayed process
A phenotype of a cell where mitotic metaphase is delayed
PMID:20360735
metaphase delay
CMPO:0000307
metaphase delayed phenotype
metaphase delayed
A phenotype where the cell migration is impaired
abnormal cell migration
CMPO:0000309
impaired cell migration
A phenotype where the cell migration process occurs for longer, typically observed as a cell moving a further distance
PMID:20360735
CMPO:0000312
increased duration of cell migration process phenotype
increased duration of cell migration process
A phenotype where the cell migration process duration is reduced, typically observed as a cell moving a shorter distance
CMPO:0000313
decreased duration of cell migration process phenotype
decreased duration of cell migration process
A phenotype observation at the level of the exit from mitosis
CMPO:0000314
exit from mitosis phenotype
exit from mitosis
A phenotype observation at the level of a cellular process where the cell process is absent
cell physiology phenotype
CMPO:0000315
absence of cell process phenotype
absence of cell process
A phenotype observation of the process in which the cell growth is abnormal
CMPO:0000316
abnormal cell growth phenotype
abnormal cell growth
A phenotype observation of the process in which the cell growth is arrested
CMPO:0000317
cell growth arrested phenotype
cell growth arrested
A phenotype observation where the rate of release of proteins from a cell is mildly decreased
PMID:22660414
mild inhibition of protein secretion
CMPO:0000318
mild decrease in rate of protein secretion
A phenotype observation where the rate of release of proteins from a cell is severly decreased
PMID:22660414
strong inhibition of protein secretion
CMPO:0000319
strong decrease in rate of protein secretion
A phenotype observation where there is an increased occurance of cell spreading
CMPO:0000320
increased cell spreading phenotype
increased cell spreading
A phenotype observation where there is a mild increase of cell spreading
PMID:19667130
moderate cell spreading
CMPO:0000321
mild increase of cell spreading phenotype
mild increase of cell spreading
A phenotype observation where there is a severe increase in cell spreading
extensive cell spreading
CMPO:0000322
strong increase of cell spreading phenotype
strong increase of cell spreading
A phenotype observation where there is a decreased occurance of cell spreading
PMID:19667130
poor cell spreading
CMPO:0000323
decreased cell spreading phenotype
decreased cell spreading
A phenotype observation where cell spreading is absent
no spreading cells
CMPO:0000324
absence of cell spreading phenotype
absence of cell spreading
A phenotype observation where a cell shows a thin and large projected areas, with developed matrix adhesions at the cell periphery, as opposed to round cells with no or few adhesion sites
spreading cell shape
CMPO:0000325
spread cell morphology phenotype
spread cell morphology
A phenotype observation of the process in which the chromosome segregation is abnormal
PMID:20360735
chromatin bridges
lagging chromosomes
multiple DNA masses
segregation problems
CMPO:0000326
abnormal chromosome segregation phenotype
abnormal chromosome segregation
A phenotype observation at the level of the mitotic prophase of the cell cycle
CMPO:0000327
mitotic prophase phenotype
mitotic prophase phenotype
A phenotype observation where the duration of the mitotic prophase of the cell cycle is increased
CMPO:0000328
increased duration of mitotic prophase phenotype
increased duration of mitotic prophase
A phenotype observation where the duration of the mitotic prophase of the cell cycle is decreased
CMPO:0000329
decreased duration of mitotic prophase phenotype
decreased duration of mitotic prophase
A phenotype observation where the frequency of a process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB is decreased.
decreased number of oscillations; the amplitude of the first peak is comparable to control, although the duration may be increased; the time of the second and third peaks is delayed, due to greater interval times between termination and initiation of nuclear translocation responses
PMID:23300644
decreased NF-kB oscillation
CMPO:0000330
decreased frequency of negative regulation of NF-kappaB transcription factor activity phenotype
decreased frequency of negative regulation of NF-kappaB transcription factor activity
A phenotype observation where the frequency of a process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB is increased.
increased number of oscillations; the amplitude of the second and third peak is increased and nuclear translocation responses occur at increased intervals.
PMID:23300644
increased NF-kB oscillation
CMPO:0000331
increased frequency of negative regulation of NF-kappaB transcription factor activity phenotype
increased frequency of negative regulation of NF-kappaB transcription factor activity
A phenotype observation where the frequency of a process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB is increased.
increased number of oscillations; the amplitude of the second and third peak is increased and nuclear translocation responses occur at increased intervals.
PMID:23300644
no NF-kB oscillation phenotype
CMPO:0000332
cytoplasmic sequestering of NF-kappaB phenotype
cytoplasmic sequestering of NF-kappaB
A phenotype observation where the release of NF-kappaB from specific molecules in the cytoplasm to which it was bound, thereby allowing its translocation into the nucleus, is abnormal.
contains all cases that are significantly different from the rest, but don't share any clear commonalities. NF-kB oscillation patterns are not synchronized within a cell population, oscillation amplitude and frequency follow erratic patterns
PMID:23300644
different NF-kB oscillation phenotype
CMPO:0000333
abnormal release of cytoplasmic sequestered NF-kappaB phenotype
abnormal release of cytoplasmic sequestered NF-kappaB
A phenotype observation where any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
CMPO:0000334
regulation of process phenotype
regulation of process phenotype
A phenotype obervation where the nuclear body's color brightness is relatively high.
pmid:22884692
increased intensity of nuclear body
CMPO:0000335
bright nuclear body phenotype
bright nuclear body
A phenotype observation where the shape of the focal adhesion has every part of the surface or the circumference equidistant from the center.
CMPO:0000337
round focal adhesion
A phenotype of a cell that is arrested at mitosis
PMID:20360735
mitotic arrest
CMPO:0000338
mitosis arrested
A population of cells where there is an increased number of large cells in the population
large cells
CMPO:0000340
increased cell size in population
increased cell size in population
A phenotype observation at the level of the nucleus underoging Pyknosis, or karyopyknosis, consisting of the irreversible condensation of chromatin in the nucleus of a cell undergoing necrosis or apoptosis.
pyknotic cell
pyknotic nucleus
CMPO:0000341
pyknotic nuclear phenotype
A phenotype of a cell arrested in mitotic prometaphase
prometaphase arrest
CMPO:0000343
prometaphase arrested phenotype
prometaphase arrested
A phenotype of a cell where mitotic prometaphase is delayed
prometaphase delay
CMPO:0000344
prometaphase delayed phenotype
prometaphase delayed
A population of cells where the nuclei exhibit a high variability of shape
variable cell shape
CMPO:0000345
increased variability of nuclear shape in population
A phenotype observation where the rate of intracellular protein transport is decreased
pmid:21795383
CMPO:0000346
decreased rate of intracellular protein transport phenotype
decreased rate of intracellular protein transport
A phenotype resulting in the absence of mitotic metaphase process
CMPO:0000347
absence of mitotic metaphase process phenotype
absence of mitotic metaphase
A phenotype observation at the level of the cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis.
metaphase alignment problem
CMPO:0000348
mitotic metaphase plate congression phenotype
mitotic metaphase plate congression
A phenotype where an increased formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell is observed.
increased protrusive activity
CMPO:0000349
increased substrate-dependent cell migration, cell extension phenotype
increased substrate-dependent cell migration, cell extension
A phenotype where an increased occurrence of the orderly movement of a cell from one site to another along a substrate such as the extracellular matrix is observed.
increased directional cell migration
CMPO:0000350
increased substrate-dependent cell migration phenotype
increased substrate-dependent cell migration
A phenotype where an increased occurance of any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins, is observed.
microtubule processes
CMPO:0000351
increased microtubule-based processes phenotype
increased microtubule-based processes
A phenotype observation of the process in which a cell increases in size due to polarized growth from one end of a cell.
increased polar cell elongation
CMPO:0000353
increased monopolar cell elongation phenotype
increased monopolar cell elongation
A phenotype observation of the process in which a cell decreases in size due to polarized growth from one end of a cell.
decreased polar cell elongation
CMPO:0000354
decreased monopolar cell elongation phenotype
decreased monopolar cell elongation
A phenotype of a cell contraction caused by an actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in mild contraction of all or part of the cell body.
CMPO:0000355
mild actin-mediated cell contraction phenotype
mild actin-mediated cell contraction
A phenotype where any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location is observed
cell component localization
CMPO:0000356
cell component localization phenotype
cell component localisation
A phenotype observation where the shape of the nucleus resembles a many-lobed berry, such as a raspberry.
acinus nuclear phenotype
CMPO:0000357
polylobed nuclear phenotype
A phenotype of a cell where the rate of DNA amplification is increased
CMPO:0000358
increased rate of DNA amplification
increased rate of DNA amplification
A phenotype observation where a cell has an increased amount of DNA
CMPO:0000359
increased amount of DNA
increased amount of DNA
A phenotype of a cell in which the biological process resulting in a doubling of the number of centrioles in the cell is affected
pmid:18620859
centriole duplication phenotype
CMPO:0000360
centriole replication phenotype
centriole replication
A phenotype of a cell in which the biological process resulting in a the number of centrioles is increased
centriole amplification phenotype
CMPO:0000361
increased centriole replication phenotype
increased centriole replication
A phenotype of a cell in which the biological process resulting in a the number of centrioles is decreased
centriole underduplication phenotype
CMPO:0000362
decreased centriole replication phenotype
decreased centriole replication
CMPO:0000363
protein localization to cellular component phenotype
A phenotype observation at the level of the cell shape where the cell is in a shape that consists of two curves in opposite directions.
PMID: 25373780
FYPO:0002760
kinked cell
kinky cell
sigmoid cell
z-shaped cell
CMPO:0000364
s-shaped cell phenotype
S-shaped cell
A phenotype observation at the level of the cell shape where the cell is curved along the long axis.
PMID: 25373780
FYPO:0002112
CMPO:0000365
curved cell phenotype
Curved cell
A phenotype observation at the level of the cell shape where the shape is in the form of a pear. One end is rounded, while the other is rod-shaped.
PMID: 25373780
FYPO:0002903
skittle-shaped cell
CMPO:0000366
pear-shaped cell phenotype
Pear-shaped cell
A phenotype observation at the level of the cell shape where the shape is stubby. The cell diameter is larger than normal and the cell length is shorter than normal.
PMID: 25373780
wide cell
FYPO:0002106
CMPO:0000367
stubby cell phenotype
Stubby cell
A phenotype observation at the level of the microtubule cytoskeleton relating to the components shape, size or structure
CMPO:0000368
microtubule cytoskeleton morphology phenotype
microtubule cytoskeleton morphology
A physical cellular phenotype in interphase of the mitotic cell cycle where the the size, shape, or structure of the microtubule cytoskeleton is observed.
PMID: 25373780
FYPO:0003625
CMPO:0000369
microtubule cytoskeleton morphology during mitotic interphase
microtubule cytoskeleton morphology during mitotic interphase
A physical cellular phenotype which cells form cytoplasmic microtubules that are longer than normal.
PMID: 25373780
FYPO:0000233
elongated cytoplasmic microtubules
long cytoplasmic microtubules
CMPO:0000370
elongated cytoplasmic microtubules phenotype
elongated cytoplasmic microtubules
A physical cellular phenotype which cells form cytoplasmic microtubules that are shorter than normal.
PMID: 25373780
FYPO:0002401
shortened cytoplasmic microtubules
CMPO:0000371
shortened cytoplasmic microtubules phenotype
elongated cytoplasmic microtubules
A phenotype observation at the level of microtubule bundle where the components number has increased.
PMID: 25373780
FYPO:0003595
extra microtubule bundles
increased level of MT bundles
increased microtubule bundling
more microtubule bundles
CMPO:0000372
increased number of microtubule bundle phenotype
increased number of microtubule bundle
A phenotype observation at the level of the microtubule relating to the components shape, size or structure
PMID: 25373780
CMPO:0000373
microtubule morphology phenotype
microtubule morphology
A phenotype observation at the level of the microtubule relating to the components shape, size or structure observed in mitotic interphase.
PMID: 25373780
CMPO:0000374
microtubule morphology during interphase phenotype
microtubule morphology during interphase
An increased number of interphase microtubule phenotype in population.
PMID: 25373780
CMPO:0000375
more cells with interphase microtubule phenotype
more cells with interphase microtubule
A phenotype observation at the level of the microtubule spindle relating to the components shape, size or structure
PMID: 25373780
CMPO:0000376
microtubule spindle morphology phenotype
microtubule spindle morphology
A phenotype observation at the level of the microtubule spindle relating to the components shape, size or structure observed during metaphase.
PMID: 25373780
CMPO:0000377
microtubule spindle morphology during metaphase phenotype
microtubule spindle morphology during metaphase
An increased number of metaphase microtubule spindles in population.
PMID: 25373780
SP increased
CMPO:0000378
more cells with metaphase microtubule spindles phenotype
more cells with metaphase microtubule spindles
A phenotype observation at the level of the microtubule where the microtuble are narrow, with the two opposite margins parallel.
PMID: 25373780
CMPO:0000379
linear microtubule morphology phenotype
linear microtubule morphology
A phenotype obesrvation relating to the orgnaistation of cellular componets in the cell.
CMPO:0000380
cell component organisation phenotype
cell component organisation
A phenotype observation relating to the organisation of cellular components in the cell.
CMPO:0000381
microtubule organisation phenotype
cell component organisation
A phenotype observation relating to the organisation of microtubules in the cell, where the microtubules are organized into an array.
PMID: 25373780
CMPO:0000382
microtubule array phenotype
microtubule array
An increased number of interphase microtubule array phenotype in population.
PMID: 25373780
IP increased
CMPO:0000383
more cells with interphase microtubule arrays phenotype
more cells with interphase microtubule arrays
A phenotype observation at the level of interphase of the cell cycle
CMPO:0000384
interphase phenotype
interphase phenotype
A phenotype observation at the level of interphase of the cell cycle
CMPO:0000385
mitotic interphase phenotype
mitotic interphase phenotype
A phenotype observation at the level of anaphase of the cell cycle
CMPO:0000386
anaphase phenotype
anaphase phenotype
A decreased number of metaphase microtubule spindles in population.
PMID: 25373780
SP reduced
CMPO:0000387
fewer cells with metaphase microtubule spindles phenotype
fewer cells with metaphase microtubule spindles
A decreased number of interphase microtubule array phenotypes in population.
PMID: 25373780
IP reduced
CMPO:0000388
fewer cells with interphase microtubule arrays phenotype
fewer cells with interphase microtubule arrays
A phenotype observation in which a protein is observed to be localized within the Golgi apparatus.
PMID: 23509072
protein localised in Golgi
protein localised in Golgi apparatus
protein localized to Golgi
protein localized to Golgi apparatus
CMPO:0000390
protein localized in golgi phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within the Golgi apparatus.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PMID: 23509072
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in Golgi
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in Golgi apparatus
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localized to Golgi
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localized to Golgi apparatus
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a cellular bud neck.
PMID: 23509072
protein localised in bud neck
protein localized in cellular bud neck
protein localized to bud neck
CMPO:0000391
protein localized in bud neck phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a cellular bud neck.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PMID: 23509072
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in bud neck
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localized in cellular bud neck
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localized to bud neck
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within the cell periphery.
PMID: 23509072
protein localised in cell periphery
protein localized to cell periphery
CMPO:0000392
protein localized in cell periphery phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within the cell periphery.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PMID: 23509072
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in cell periphery
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localized to cell periphery
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within the cytosol.
PMID: 23509072
protein localised in cytosol
protein localized to cytosol
CMPO:0000393
protein localized in cytosol phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within the cytosol.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PMID: 23509072
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in cytosol
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localized to cytosol
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within the endoplasmic reticulum.
PMID: 23509072
protein localised in endoplasmic reticulum
protein localized to endoplasmic reticulum
CMPO:0000394
protein localized in endoplasmic reticulum phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within the endoplasmic reticulum.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PMID: 23509072
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in endoplasmic reticulum
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localized to endoplasmic reticulum
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a mitochondrion.
PMID: 23509072
protein localised in mitochondria
protein localised in mitochondrion
protein localized to mitochonria
protein localized to mitochonrion
CMPO:0000395
protein localized in mitochondrion phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a mitochondrion.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PMID: 23509072
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in mitochondria
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in mitochondrion
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localized to mitochonria
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localized to mitochonrion
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within the nuclear periphery.
PMID: 23509072
protein localised in nuclear periphery
protein localized to nuclear periphery
CMPO:0000396
protein localized in nuclear periphery phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within the nuclear periphery.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PMID: 23509072
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in nuclear periphery
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localized to nuclear periphery
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within the nucleolus.
PMID: 23509072
protein localised in nucleolus
protein localized to nucleolus
CMPO:0000397
protein localized in nucleolus phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within the nucleolus.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PMID: 23509072
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in nucleolus
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localized to nucleolus
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within the nucleus.
PMID: 23509072
protein localised in nucleus
protein localized to nucleus
CMPO:0000398
protein localized in nucleus phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within the nucleus.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PMID: 23509072
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in nucleus
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localized to nucleus
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a peroxisome.
PMID: 23509072
protein localised in peroxisome
protein localized to peroxisome
CMPO:0000399
protein localized in peroxisome phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a peroxisome.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PMID: 23509072
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in peroxisome
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localized to peroxisome
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within punctate foci
PMID: 23509072
protein localised in punctate foci
protein localized to punctate foci
CMPO:0000400
protein localized in punctate foci phenotype
A phenotype observation in which a protein is observed to be localized within punctate foci
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PMID: 23509072
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in punctate foci
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localized to punctate foci
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a vacuole.
PMID: 23509072
protein localised in vacuole
protein localized to vacuole
CMPO:0000401
protein localized in vacuole phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a vacuole.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PMID: 23509072
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in vacuole
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localized to vacuole
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a vacuolar membrane.
PMID: 23509072
protein localised in vacuolar membrane
protein localized to vacuolar membrane
CMPO:0000402
protein localized in vacuolar membrane phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a vacuolar membrane.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PMID: 23509072
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in vacuolar membrane
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localized to vacuolar membrane
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within the nuclear body.
protein localised in nuclear body
protein localized to nuclear body
CMPO:0000403
protein localized to nuclear body
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within the nuclear body.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in nuclear body
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localized to nuclear body
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a Cajal body.
PubMed ID:24127217
protein localised in Cajal body phenotype
CMPO:0000404
protein localized in Cajal body phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a Cajal body.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PubMed ID:24127217
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in Cajal body phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a nuclear speckle.
PubMed ID:24127217
protein localised in nuclear speckle phenotype
CMPO:0000405
protein localized in nuclear speckle phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a nuclear speckle.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PubMed ID:24127217
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in nuclear speckle phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a paraspeckle.
PubMed ID:24127217
protein localised in paraspeckle phenotype
CMPO:0000406
protein localized in paraspeckle phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a paraspeckle.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PubMed ID:24127217
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in paraspeckle phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a PML body.
PubMed ID:24127217
protein localised in PML body phenotype
protein localised in Promyelocytic Leukemia nuclear body phenotype
protein localized in Promyelocytic Leukemia nuclear body phenotype
CMPO:0000407
protein localized in PML body phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a PML body.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PubMed ID:24127217
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in PML body phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in Promyelocytic Leukemia nuclear body phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localized in Promyelocytic Leukemia nuclear body phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a polycomb body.
PubMed ID:24127217
protein localised in PcG body phenotype
protein localized in PcG body phenotype
protein localized in polycomb body phenotype
CMPO:0000408
protein localized in polycomb body phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a polycomb body.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PubMed ID:24127217
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in PcG body phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localized in PcG body phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localized in polycomb body phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a Sam68 nuclear body.
PubMed ID:24127217
protein localised in Sam68 nuclear body phenotype
CMPO:0000409
protein localized in Sam68 nuclear body phenotype
A phenotype observation in which a protein is observed to be localized within a Sam68 nuclear body.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PubMed ID:24127217
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in Sam68 nuclear body phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A decreased number of post-anaphase or G1 phase microtubule arrays in population phenotype
PMID: 25373780
PAA decreased
fewer cells with post-anaphase microtubule arrays
CMPO:0000410
fewer cells with G1 phase microtubule arrays phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A decreased number of post-anaphase or G1 phase microtubule arrays in population phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PMID: 25373780
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PAA decreased
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
fewer cells with post-anaphase microtubule arrays
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A decreased number of post-mitotic interphase or S phase microtubule arrays in population phenotype
PMID: 25373780
IP2 decreased
fewer cells with post-mitotic interphase microtubule arrays
CMPO:0000411
fewer cells with S phase microtubule arrays phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A decreased number of post-mitotic interphase or S phase microtubule arrays in population phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PMID: 25373780
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
IP2 decreased
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
fewer cells with post-mitotic interphase microtubule arrays
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
An increased number of post-anaphase or G1 phase microtubule arrays in population phenotype
PMID: 25373780
PAA increased
more cells with post-anaphase microtubule arrays
CMPO:0000412
more cells with G1 phase microtubule arrays phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
An increased number of post-anaphase or G1 phase microtubule arrays in population phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PMID: 25373780
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PAA increased
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
more cells with post-anaphase microtubule arrays
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
An increased number of post-mitotic interphase or S phase microtubule arrays in population phenotype
PMID: 25373780
IP2 increased
more cells with post-mitotic interphase microtubule arrays
CMPO:0000413
more cells with S phase microtubule arrays phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
An increased number of post-mitotic interphase or S phase microtubule arrays in population phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PMID: 25373780
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
IP2 increased
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
more cells with post-mitotic interphase microtubule arrays
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation of respone to stress process within a cell. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
CMPO:0000414
cell response to stress phenotype
cell response to stress
A phenotype observation of a process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
DNA damage
CMPO:0000415
cell response to DNA damage phenotype
cell response to DNA damage
The population has a decreased number of cells forming cell-cell aggregates.
PMID:24446484
defective cell-cell aggregation
CMPO:0000416
fewer aggregated cells in population phenotype
fewer aggregated cells in population
A phenotype observation in which a protein is absent or decreased from the expected localisation of protein localisation process
PMID: 23547032
protein absent from localisation to cellular component
CMPO:0000417
example 'the smt3allR mutant does not show localization at the bud neck'
lack of protein in cell component localization phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is absent or decreased from the expected localisation of protein localisation process
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PMID: 23547032
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein absent from localisation to cellular component
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation at the level of a response to stimulus process
CMPO:0000419
response to stimulus phenotype
A phenotype observation at the level of a response to stimulus process
CMPO:0000420
response to chemical phenotype
A phenotype observation at the level of a response to stimulus process
CMPO:0000421
cellular response to chemical stimulus phenotype
A phenotype observation at the level of telophase of the cell cycle
CMPO:0000422
telophase phenotype
telophase phenotype
A phenotype observation at the level of mitotic telophase of the cell cycle
CMPO:0000423
mitotic telophase phenotype
telophase phenotype
A phenotype of a cell where the mitotic telophase process is arrested, or ends earlier in time than expected
CMPO:0000424
telophase arrested phenotype
telophase arrested
A phenotype observation in which a protein is observed to be localized within a centrosome.
PMID:23086237
protein localisation in centrosome
protein localised in centrosome
protein localised to centrosome
protein localization in centrosome
CMPO:0000425
protein localized in centrosome phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a centrosome.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PMID:23086237
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localisation in centrosome
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in centrosome
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised to centrosome
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localization in centrosome
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a nuclear pore.
PMID:23845946
protein localisation in nuclear pore
protein localised in nuclear pore
protein localised to nuclear pore
protein localization in nuclear pore
CMPO:0000426
protein localized in nuclear pore phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a nuclear pore.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PMID:23845946
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localisation in nuclear pore
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in nuclear pore
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised to nuclear pore
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localization in nuclear pore
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A collection of qualities that inhere in any constituent part of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
CMPO:0000427
kinetochore phenotype
kinetochore phenotype
A phenotype observation at the level of the cell shape where the cell is fan-shaped
CMPO:0000428
fan-shaped cell phenotype
fan-shaped cell
A phenotype observation at the level of the cell protein
cell protein phenotype
CMPO:0000429
cell polypeptide phenotype
cell protein phenotype
A cell phenotype in which the amount of a specific substance measured in a cell differs from normal.
FYPO:0000989
PomBase:mah
CMPO:0000430
altered level of substance in cell
altered level of substance in cell
A cell phenotype in which the amount of polypetide measured in a cell differs from normal.
CMPO:0000431
altered level of polypetide in cell
altered level of polypeptide in cell
A cell phenotype in which the amount of polypetide measured in a cell nucleus differs from normal.
altered level of protein in cell nucleus
CMPO:0000432
altered level of polypetide in cell nucleus
altered level of substance in cell nucleus
A cell phenotype in which the amount of polypetide measured in a cell nucleus increases from normal.
increased level of protein in cell nucleus
CMPO:0000433
increased level of polypetide in cell nucleus
incressed level of polypetide in cell nucleus
A cell phenotype in which the amount of polypetide measured in a cell nucleus descreases from normal.
decreased level of protein in cell nucleus
CMPO:0000434
decreased level of polypetide in cell nucleus
descreased level of polypetide in cell nucleus
A phenotype observation where any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.
CMPO:0000435
negative regulation of protein import into nucleus phenotype
regulation of process phenotype
A phenotype observation where any process that starts or increases the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.
CMPO:0000436
positive regulation of protein import into nucleus phenotype
positive regulation of protein import into nucleus
A phenotype where the mitotic cell cycle phase is abnormal
CMPO:0000437
abnormal mitotic cell cycle phase phenotype
abnormal mitotic cell cycle phase
A physical cellular phenotype in interphase of the mitotic cell cycle where the the size, shape, or structure of the microtubule cytoskeleton is abnormal.
PMID: 25373780
FYPO:0003625
CMPO:0000438
abnormal microtubule cytoskeleton morphology during mitotic interphase
abnormal microtubule cytoskeleton morphology during mitotic interphase
A phenotype observation in which a protein is not localized within a cellular bud neck.
CMPO:0000439
absence of protein localized in bud neck phenotype
A phenotype observation in which a protein is not localized within a cellular bud neck.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within an actin filament.
PubMed: 22361696
protein localised in actin filament phenotype
CMPO:0000440
protein localized in actin filament phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within an actin filament.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PubMed: 22361696
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in actin filament phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within an intermediate filament.
PubMed: 22361696
protein localised in intermediate filament phenotype
CMPO:0000441
protein localized in intermediate filament phenotype
A phenotype observation in which a protein is observed to be localized within an intermediate filament.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PubMed: 22361696
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in intermediate filament phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a microtubule.
PubMed: 22361696
protein localised in microtubule phenotype
CMPO:0000442
protein localized in microtubule phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a microtubule.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PubMed: 22361696
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in microtubule phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized the nuclear membrane.
PubMed: 22361696
protein localised in nuclear envelope phenotype
protein localised in nuclear membrane phenotype
CMPO:0000443
protein localized in nuclear membrane phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized the nuclear membrane.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PubMed: 22361696
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in nuclear membrane phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within the nucleolar fibrillar center.
PubMed: 22361696
protein localised in nucleoli fibrillar center phenotype
CMPO:0000444
protein localized in nucleoli fibrillar center phenotype
A phenotype observation in which a protein is observed to be localized within the nucleolar fibrillar center.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PubMed: 22361696
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in nucleoli fibrillar center phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within the nucloplasm.
PubMed: 22361696
protein localised in nucleoplasm phenotype
CMPO:0000445
protein localized in nucleoplasm phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within the nucloplasm.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PubMed: 22361696
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in nucleoplasm phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within the plasma membrane.
PubMed: 22361696
protein localised in plasma membrane phenotype
CMPO:0000446
protein localized in plasma membrane phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within the plasma membrane.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PubMed: 22361696
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in plasma membrane phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype observation in which a protein is observed to be localized within a vesicle.
PubMed: 22361696
protein localised in vesicle phenotype
CMPO:0000447
protein localized in vesicle phenotype
A phenotype observation in which a protein is observed to be localized within a vesicle.
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
PubMed: 22361696
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
protein localised in vesicle phenotype
http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern
A phenotype where the the cells are killing either its own cells or those of another organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.
CMPO:0000448
cell killing phenotype
cell killing phenotype
A phenotype where the the cells are killing either its own cells or those of another organism. The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
'T cell mediated cytotoxicity directed against tumor cell target phenotype
CMPO:0000449
T cell mediated killing against a tumor cell phenotype
T cell mediated killing against a tumor cell phenotype
The population has an increased number of cells forming cell-cell aggregates.
CMPO:0000450
more aggregated cells in population phenotype
more aggregated cells in population phenotype
A phenotype observation where the area of the nucelus has increased.
CMPO:0000451
increased nuclear area phenotype
increased nuclear area phenotype
A phenotype observation where the area of the nucelus has decreased.
CMPO:0000452
decreased nuclear area phenotype
decreased nuclear area phenotype
A population of cells where there is an increased number of small cells in the population
small cells
CMPO:0000453
decreased cell size in population
decreased cell size in population
A phenotype observation where a cellular componet is localised to one side of the cell with respect to the other
asymmetric component
CMPO:0000454
asymmetric cellular component phenotype
asymmetric component
A cell phenotype in which the amount of polypetide measured in a cell is decreased from normal.
decreased level of protein in the cell
CMPO:0000455
decreased level of polypetide in the cell
decreased level of polypetide in the cell
A cell phenotype in which the amount of polypetide measured in a cell is increased from normal.
increased level of protein in the cell
CMPO:0000456
increased level of polypetide in the cell
increased level of polypetide in the cell
A population of cells where there is is an increased number of cells with a decreased nucleus to cell area ratio
CMPO:0000457
decreased nucleus to cell area ratio
decreased nucleus to cell area ratio
A population of cells where there is is an increased number of cells with an increased nucleus to cell area ratio
CMPO:0000458
increased nucleus to cell area ratio
increased nucleus to cell area ratio
inheres in at all times
has phenotype