Terminology Service for NFDI4Health
podosome
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http://purl.obolibrary.org/obo/GO_0002102
An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. [ http://www.ncbi.nlm.nih.gov/pubmed/15890982 http://www.ncbi.nlm.nih.gov/pubmed/12837608 ]
Term info
Label
podosome
IAO 0000412
http://purl.obolibrary.org/obo/go.owl
comment
Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation.
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cellular_component
id
GO:0002102