calcitriol
A hydroxycalciol that has formula C27H44O3.
Encoded by human CYP8B1 Gene (Cytochrome P450 Family), 501-aa 58-kDa Cytochrome P450 8B1 is a liver endoplasmic reticulum membrane P450 heme-thiolate monooxygenase involved in bile acid synthesis that catalyzes conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these steroids determines the relative amount of cholic and chenodeoxycholic acids secreted in the bile that affect cholesterol solubility. CYP8B1 has broad substrate specificity including 7-alpha-hydroxylated C27 steroids. P450 enzymes catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (NCI)
Term info
calcitriol
- (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol
- (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3,25-triol
- (1alpha,3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol
- 1,25-DHCC
- 1alpha,25(OH)2D3
- 1alpha,25-dihydroxycholecalciferol
- 1alpha,25-dihydroxyvitamin D3
- 1alpha,25-dihydroxyvitamin D3; 1,25-dihydroxyvitamin D3; 1,25(OH)2D3
- 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL
- 7 Alpha-Hydroxy-4-Cholesten-3-One 12-Alpha-Hydroxylase
- C27H44O3
- CYP8B1
- CYPVIIIB1
- Calcijex
- Cytochrome P450 8B1
- Cytochrome P450 CYP8B1
- Cytochrome P450 Family 8 Subfamily B Polypeptide 1
- Cytochrome P450 Subfamily VIIIB (Sterol 12-Alpha-Hydroxylase) Polypeptide 1
- Decostriol
- InChI=1/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
- InChIKey=GMRQFYUYWCNGIN-NKMMMXOEBI
- Rocaltrol
- Steroid 12-Alpha-Hydroxylase
- Sterol 12 Alpha Hydroxylase
- [H][C@@]1(CC[C@@]2([H])\\C(CCC[C@]12C)=C\\C=C1\\C[C@@H](O)C[C@H](O)C1=C)[C@H](C)CCCC(C)(C)O
- calcitriolum
32222-06-3, (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3,25-triol, C27H44O3, 22722