Terminology Service for NFDI4Health

calcitriol

Go to external page http://purl.obolibrary.org/obo/CHEBI_17823


A hydroxycalciol that has formula C27H44O3.

Encoded by human CYP8B1 Gene (Cytochrome P450 Family), 501-aa 58-kDa Cytochrome P450 8B1 is a liver endoplasmic reticulum membrane P450 heme-thiolate monooxygenase involved in bile acid synthesis that catalyzes conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these steroids determines the relative amount of cholic and chenodeoxycholic acids secreted in the bile that affect cholesterol solubility. CYP8B1 has broad substrate specificity including 7-alpha-hydroxylated C27 steroids. P450 enzymes catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (NCI)

Term info

Label

calcitriol

Synonyms
  • (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol
  • (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3,25-triol
  • (1alpha,3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol
  • 1,25-DHCC
  • 1alpha,25(OH)2D3
  • 1alpha,25-dihydroxycholecalciferol
  • 1alpha,25-dihydroxyvitamin D3
  • 1alpha,25-dihydroxyvitamin D3; 1,25-dihydroxyvitamin D3; 1,25(OH)2D3
  • 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL
  • 7 Alpha-Hydroxy-4-Cholesten-3-One 12-Alpha-Hydroxylase
  • C27H44O3
  • CYP8B1
  • CYPVIIIB1
  • Calcijex
  • Cytochrome P450 8B1
  • Cytochrome P450 CYP8B1
  • Cytochrome P450 Family 8 Subfamily B Polypeptide 1
  • Cytochrome P450 Subfamily VIIIB (Sterol 12-Alpha-Hydroxylase) Polypeptide 1
  • Decostriol
  • InChI=1/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
  • InChIKey=GMRQFYUYWCNGIN-NKMMMXOEBI
  • Rocaltrol
  • Steroid 12-Alpha-Hydroxylase
  • Sterol 12 Alpha Hydroxylase
  • [H][C@@]1(CC[C@@]2([H])\\C(CCC[C@]12C)=C\\C=C1\\C[C@@H](O)C[C@H](O)C1=C)[C@H](C)CCCC(C)(C)O
  • calcitriolum
database cross reference
definition citation

32222-06-3, (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3,25-triol, C27H44O3, 22722

Term relations

Subclass of: