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bicuculline

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Bicuculline is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species.

Term info

Label

bicuculline

Synonyms
  • (6R)-6-[(5S)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e][1,3]benzodioxol-8(6H)-one
  • Bicculine
  • Bicucullin
  • C20H17NO6
  • InChI=1/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
  • InChIKey=IYGYMKDQCDOMRE-ZWKOTPCHBP
  • [H][C@]1(OC(=O)c2c3OCOc3ccc12)[C@@]1([H])N(C)CCc2cc3OCOc3cc12
  • d-Bicuculline
database cross reference
EFO URI

http://www.ebi.ac.uk/efo/EFO_0002725

definition citation

CHEBI_3092

term editor

Ele Holloway, Tomasz Adamusiak

Term relations

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