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methyltrienolone

Go to external page http://purl.obolibrary.org/obo/CHEBI_379896

Human USP6 wild-type allele is located within 17p13 and is approximately 47 kb in length. This allele, which encodes ubiquitin carboxyl-terminal hydrolase 6 protein, is involved in protein binding and the cleavage of free ubiquitin chains. The USP6 gene is overexpressed in a specific osseous neoplasm termed an aneurysmal bone cyst.

A synthetic non-aromatisable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors.

Term info

Label

methyltrienolone

Synonyms
  • 17-methyloestra-4,9,11-trien-3-one,17beta-ol
  • 17alpha-Methyltrienolone
  • 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one
  • C19H24O2
  • InChI=1/C19H24O2/c1-18-9-7-15-14-6-4-13(20)11-12(14)3-5-16(15)17(18)8-10-19(18,2)21/h7,9,11,16-17,21H,3-6,8,10H2,1-2H3/t16-,17+,18+,19+/m1/s1
  • InChIKey=CCCIJQPRIXGQOE-XWSJACJDBS
  • Proto-Oncogene TRE-2
  • R1881
  • R1881 (synthetic androgen)
  • TRE-2 Gene
  • USP6 wt Allele
  • Ubiquitin Specific Protease 6 (Tre-2 Oncogene) wt Allele
  • Ubiquitin Specific Protease 6 Gene
  • [H][C@@]12CCC3=CC(=O)CCC3=C1C=C[C@@]1(C)[C@@]2([H])CC[C@]1(C)O
  • metribolona
  • metribolone
  • metribolonum
database cross reference
definition citation

C19H24O2, 14162, (17beta)-17-hydroxy-17-methylestra-4,9,11-trien-3-one, 34162, 965-93-5

Term relations