Terminology Service for NFDI4Health

phosmet

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An organothiophosphate insecticide that has formula C11H12NO4PS2.

A radiotracer consisting of choline labeled with the positron-emitting isotope carbon C 11 with potential imaging use. Upon administration, C-11 choline incorporates into tumor cells through an active, carrier-mediated transport mechanism for choline and then is phosphorylated intracellularly by choline kinase, an enzyme frequently upregulated in human tumors, yielding phosphoryl C-11 choline. In turn, phosphoryl C-11 choline is integrated into phospholipids in the cell membrane as part of phosphatidylcholine. As the proliferation of cancer cells is much higher than normal cells, tumor cells exhibit an increased rate of C-11 choline uptake and incorporation, allowing tunor imaging with positron emission tomography (PET).

Term info

Label

phosmet

Synonyms
  • C-11 Choline
  • C11 Choline
  • C11H12NO4PS2
  • COP(=S)(OC)SCN1C(=O)c2ccccc2C1=O
  • Carbon C 11 Choline
  • Carbon C11 Choline
  • Decemthion
  • Fosmet
  • InChI=1/C11H12NO4PS2/c1-15-17(18,16-2)19-7-12-10(13)8-5-3-4-6-9(8)11(12)14/h3-6H,7H2,1-2H3
  • InChIKey=LMNZTLDVJIUSHT-UHFFFAOYAV
  • O,O-Dimethyl S-(phthalimidomethyl) dithiophosphate
  • O,O-Dimethyl S-phthalimidomethyl phosphorodithioate
  • O,O-Dimethyl phthalimidomethyl phosphorodithioate
  • PMP
  • S-((1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl)phosphorodithioic acid O,O-dimethyl ester
  • S-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl] O,O-dimethyl dithiophosphate
  • S-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl] O,O-dimethyl phosphorodithioate
database cross reference
definition citation

732-11-6, 4261, 24261, S-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl] O,O-dimethyl dithiophosphate, C11H12NO4PS2

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